34 results about "Cyanopyrazine" patented technology

The present invention relates to a kind of synthetic technology of favipiravir intermediate 3,6-dichloro-2-cyanopyrazine, it is characterized in that, synthetic route is as follows. The present invention uses relatively cheap 2-chloropyrazine as a raw material, and only needs two steps of reaction to obtain the product 3,6-dichloro-2-cyanopyrazine, with a total yield of more than 55%, and the reagents used can be It is a common reagent that can be purchased commercially, which reduces the production cost, and is a very large-scale synthetic process for the industrial production of 3,6-dichloro-2-cyanopyrazine. The method of the invention optimizes the synthesis process conditions, especially selects the catalyst and co-catalyst in the step (2), and further improves the yield and purity of the product.

The invention provides an application of nitrile hydratase from Sinorhizobium meliloti in preparation of an amide pyrazine compound and belongs to the technical field of biochemical engineering. The nitrile hydratase catalyzes a hydration reaction of a cyanopyrazine compound to generate an amide pyrazine compound; The nitrile hydratase is derived from the Sinorhizobium meliloti (Singorhizobium meliloti). The cyanopyrazine compound is taken as a substrate, in-vitro nitrile hydratase or cells for expressing the nitrile hydratase are taken as a catalyst, a hydration reaction is carried out, and the amide pyrazine compound can be obtained. The raw material conversion rate is high, no side reaction exists, and the product is easy to separate and purify and high in purity; Compared with the traditional chemical catalysis process, the process is green and environment-friendly, the operation is simple and convenient, and the yield exceeds 99%.

The invention relates to a refluxing improved rectifying tower for 2-cyanopyrazine. The refluxing improved rectifying tower comprises a tower body provided with an extraction hole, a plurality of pieces of tower plates and a refluxing system, wherein the refluxing system comprises an extraction pipe connected with the extraction hole, a heat exchanger connected with the extraction pipe and a refluxing main pipe connected with the heat exchanger; each tower plate comprises a hollow shell body, a plurality of sieve holes which are formed in the shell body and penetrate through the shell body, and a plurality of spraying holes which are formed in a non-sieve-hole region of the bottom surface of the shell body; a refluxing auxiliary pipe, which is communicated with the inner part of the shellbody and extends out of the tower body, is arranged on a side face of each tower plate; each refluxing auxiliary pipe is communicated with the refluxing main pipe and an auxiliary pipe valve is arranged on a pipe body; each sieve hole is internally provided with a sealing circular ring which is coaxial with the sieve hole and is fixedly connected with the shell body; a main pipe valve is arrangedat the tail end of the refluxing main pipe. According to the refluxing improved rectifying tower for the 2-cyanopyrazine, the characteristic that positions of the different tower plates correspond todifferent separation efficiency can be sufficiently utilized, so that the purification effect of single-time refluxing is remarkably improved and the refluxing time needed for reaching the effect is effectively shortened, and furthermore, the whole efficiency of refluxing operation is greatly improved.

The invention discloses an improved cyano reductase and its application in the synthesis of 3-chloropyrazine-2 methylamine, characterized in that: the improved cyano reductase is represented by SEQ ID No.2 The amino acid sequence is the starting sequence, the mutant obtained by mutating the 120th alanine to leucine, and mutating the 155th glutamic acid to lysine; Add glucose, coenzyme NADP, 2-chloro-3-cyanopyrazine, glucose dehydrogenase and improved cyanoreductase to form a reaction mixture, and carry out the reduction reaction at 30-40°C for 24 hours to generate 3-chloropyrazine -2 methylamine, the present invention has mild reaction conditions, less organic solvent consumption, more green reaction system, high conversion rate, greatly improves the preparation efficiency of 3-chloropyrazine-2 methylamine, and has good industrial application prospect.

The invention discloses a thermally active delayed fluorescence organic compound with 2-cyanopyrazine as an acceptor and its preparation and application. The structure of the thermally active delayed fluorescent organic compound is shown in the general formula (1). The compound is based on the light emitting mechanism of TADF and is used as a light emitting layer material in an organic electroluminescent device. The device produced by the invention has good photoelectric performance and can meet the requirements of panel manufacturers.

The catalyst is VMoOP system carried catalyst prepared via soaking process. The catalyst features the carrier alumina, silica gel and silicon carbide and active component V / P / Mo in the molecular ratio of 1 to 1-6 to 0.01-1. When the catalyst is used in synthesizing 2-cyanopyrazine and the user amount of catalyst is 40 g, the introduced amount of 2-methylpyrazine 0.05-2 ml / min, that of ammonia is 100-200 ml / min and that of air is 1000-2000 ml / min; the material feeding molar proportion among 2-methylpyrazine, ammonia and air is 1 to 8-20 to 10-90. The present invention has the advantages of high catalyst activity, long service life, no need of activation period, simple synthesis process, high material conversion rate and high product quality.

The invention discloses a method for synthesizing favipiravir, which specifically comprises using DMSO in combination with a microchannel reactor, or a micromixer and a microchannel reactor, and is composed of 6-fluoro-3-hydroxy-2-cyanopyrazine in NaOH and H 2 O 2 Favipiravir was prepared under the conditions. The synthesis method of the present application uses a microchannel reactor, which has high mass transfer efficiency and can significantly improve the reaction conversion rate, thereby reducing pollution and loss; the method of the present application has a short reaction time, the entire reaction time is between 1-10 minutes, and the production efficiency is high; The continuous reaction is realized, the production efficiency is improved, and the labor cost is reduced. And because the reactant hydrogen peroxide is dangerous as an oxidant, the method has high safety.