Use of human lsm5 gene and related products

A product and application technology, applied in the application of human LSM5 gene and related products, can solve the problems that the function of LSM5 has not been reported yet, and achieve the effects of inhibiting growth, promoting cell apoptosis, and inhibiting proliferation
CN110882390BActive Publication Date: 2022-03-15THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
Publication Date
2022-03-15

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Abstract

The invention belongs to the field of biomedical research, and specifically relates to the use of human LSM5 gene as a target in the preparation of colorectal cancer treatment drugs. After extensive and in-depth research, the present invention finds that the RNAi method can effectively inhibit the proliferation of colorectal cancer cells, promote cell apoptosis, and effectively control the growth process of colorectal cancer after down-regulating the expression of human LSM5 gene. The siRNA provided by the present invention or the nucleic acid construct containing the siRNA sequence, and the lentivirus can specifically inhibit the proliferation rate and proliferation ability of colorectal cancer cells, promote the apoptosis of colorectal cancer cells, inhibit the cloning of colorectal cancer cells, and inhibit the cloning of colorectal cancer cells. Cancer growth, so as to treat colorectal cancer, open up a new direction for the treatment of colorectal cancer.
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Description

technical field

[0001] The invention belongs to the field of biomedical research, and specifically relates to the use of human LSM5 gene and related products. Background technique

[0002] LSM5 (LSM5 Homolog, U6 Small Nuclear RNA And MRNA DegradationAssociated; U6 SnRNA-Associated Sm-Like Protein LSm5) is located at 7p14.3, encoding a U6 small nuclear ribonucleic acid-associated Sm-like protein, which can be found in many species , considered to have sequence homology to the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain a 2-domain Sm sequence motif, which consists of 2 domains separated by a variable-length linker that can form a cyclic fold. Sm-like proteins are known to form a stable heteromer of 3-snRNA (U4 / U6-U5), and the heptamer LSM2-8 complex specifically binds to the 3'-terminal U-region of U6 snRNA and participates in the spliceosome Assembly process that plays an important role in the splicing of pre-mRNA.

[0003] It has been reported tha...

Claims

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