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Flexible electrochemical glucose sensor and preparation method thereof

A glucose sensor and electrochemical technology, applied in the field of sensors, can solve the problems of low sensor monitoring efficiency, dense coating, poor adhesion, etc., and achieve the effects of broadening the detection range, enhancing contact, and preventing leakage

Active Publication Date: 2020-03-17
江苏跃凯生物技术有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a flexible electrochemical glucose sensor and its preparation method to solve the problem of low efficiency of sensor monitoring due to the low efficiency of sensor monitoring caused by the dense coating of glucose oxidase and electrocatalytic medium in the existing glucose sensor coating. Key problems such as poor adhesion between the coating and the electrode

Method used

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  • Flexible electrochemical glucose sensor and preparation method thereof
  • Flexible electrochemical glucose sensor and preparation method thereof
  • Flexible electrochemical glucose sensor and preparation method thereof

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Embodiment 1

[0071] A method for preparing a flexible electrochemical glucose sensor, comprising the following steps:

[0072] Carbon spheres (Cbs) were prepared by reacting 0.56 mM / mL glucose aqueous solution in a Teflon-lined stainless steel autoclave at 180 °C for 12 h;

[0073] Disperse 0.1 g of Cbs in 15 mL of ethanol, and after ultrasonication for 1 h, add 25 mL of Ce(NO 3 ) 3 ·6H 2 The aqueous solution of O (12mM) and polyvinylpyrrolidone (PVP, 3.6mg / mL) was stirred at room temperature for 2h and reacted at 75°C for 4h to prepare C@CeO 2 nanospheres;

[0074] 0.1g of C@CeO 2 Add 25 mL of KMnO to the nanospheres 4 (32mM) solution, ultrasonically dispersed for 30min, and then reacted at 80°C for 4h. After cooling to room temperature, the nanospheres were separated by suction filtration, washed with ethanol and deionized water, dried at 60 °C for 1 h, and then annealed in air at 275 °C for 2 h to prepare CeO 2 / MnO 2 Hollow nanospheres (such as figure 1 shown);

[0075] 12mL ...

Embodiment 2

[0084] A method for preparing a flexible electrochemical glucose sensor, comprising the following steps:

[0085] Carbon spheres (Cbs) were prepared by reacting 0.56 mM / mL glucose aqueous solution in a Teflon-lined stainless steel autoclave at 180 °C for 12 h;

[0086] Disperse 0.1 g of Cbs in 15 mL of ethanol, and after ultrasonication for 1 h, add 25 mL of Ce(NO 3 ) 3 ·6H 2 The aqueous solution of O (12mM) and polyvinylpyrrolidone (PVP, 3.6mg / mL) was stirred at room temperature for 2h and reacted at 75°C for 4h to prepare C@CeO 2 nanospheres;

[0087] 0.1g of C@CeO 2 Add 25 mL of KMnO to the nanospheres 4 (32mM) solution, ultrasonically dispersed for 30min, and then reacted at 80°C for 4h. After cooling to room temperature, the nanospheres were separated by suction filtration, washed with ethanol and deionized water, dried at 60 °C for 1 h, and then annealed in air at 275 °C for 2 h to prepare CeO 2 / MnO 2 Hollow nanospheres (such as figure 1 shown);

[0088] 12mL ...

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Abstract

The invention discloses a flexible electrochemical glucose sensor and a preparation method thereof, and belongs to the technical field of sensors. According to the invention, CeO2 / MnO2 hollow nanospheres are used as an electrocatalytic medium, and quaternary ammonium salt chitosan is used as a hydrogel matrix material; carboxyl modification is carried out on the surfaces of CeO2 / MnO2 hollow nanospheres, and the CeO2 / MnO2 hollow nanospheres are connected to self-healing conductive hydrogel through covalent bonds; meanwhile, GOx is loaded into the hydrogel through electrostatic interaction; andfinally, the hydrogel is externally wrapped by a layer of polymer. The method can prevent leakage of GOx and an electro-catalytic medium effectively; the prepared hydrogel sensor has the characteristics of wide linear range, quick response and high sensitivity for glucose detection; and meanwhile, the problems that a coating body of an existing glucose sensor is easy to lose, the coating is compact, and the adhesive force between the coating and an electrode is poor and the like are solved.

Description

technical field [0001] The invention relates to the technical field of sensors, in particular to a flexible electrochemical glucose sensor and a preparation method thereof. Background technique [0002] In recent decades, the number of patients with diabetes and impaired glucose tolerance in the world has increased significantly year by year. The International Diabetes Federation (IDF) predicts that by 2045, the number of patients with diabetes worldwide will increase to 629 million. Conventional treatment for diabetes is oral or subcutaneous injection of hypoglycemic drugs, and the dosage may not match the patient's immediate blood sugar level. Fatal hypoglycemia or ketoacidosis can result from overdose or underdose. Therefore, for severe diabetic patients, it is very necessary to use a continuous blood glucose monitoring system (CGMS) to monitor their blood glucose levels accurately in real time, so as to accurately administer insulin. [0003] A key component of CGMS is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327
CPCG01N27/3278
Inventor 王云兵胡雪丰张婕妤梁震
Owner 江苏跃凯生物技术有限公司
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