Tumor self-targeting photo-isomerization nano-carriers and preparation method thereof

Abstract

The invention discloses tumor self-targeting photo-isomerization nano-carriers and a preparation method thereof. Nano assembly bodies BRNPs are formed through the self-assembling of bilirubin, 3-aminophenylboronic acid and hydroxyethyl starch; and nano-carriers DBC3NPs coated with HeLa cell membranes are obtained by coating HeLa cell membrane debris on the surfaces of the BRNPs loaded with adriamycin through a continuous extrusion method. The tumor-specific target enrichment of the nano-carriers can be realized under the self-targeting action of the cell membranes; and near infrared irradiation can make nano-particles generate photo-isomerization, thus, the rapid near infrared light releasing of drugs at tumor tissue sites can be realized, and the efficient treatment of tumors can be achieved as well.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and more specifically relates to a tumor self-targeting photoisomerization nanocarrier to realize efficient cancer treatment. [0002] technical background [0003] Cancer is still one of the most intractable diseases plaguing human beings, and chemotherapy is still one of the important treatment methods. However, due to the poor water solubility, short half-life and serious side effects of chemotherapeutic drugs, their clinical application is greatly limited. As an emerging treatment, immunotherapy has been widely used in tumor treatment. Studies have shown that the presence of glucose activates the immune system and induces the aggregation of immune cells. It has been reported that hydroxyethyl starch (HES) can be degraded to glucose under the action of α-amylase, and is currently widely used as a nanocarrier material. However, its systemic toxicity is too high, which greatly limits its uti...

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Problems solved by technology

However, since passive targeting depends entirely on the concentration difference of drugs, it is impossible to increase the effective concentration of drugs in tumor lesions, so active targeted therapy of tumors has become a research hotspot.

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