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A composite hydrogel material for hemostasis and healing promotion and its preparation method and application

A composite hydrogel and fenugreek glue technology, applied in medical science, bandages, etc., can solve the problems of insufficient mechanical strength and toughness, poor biocompatibility, strong immune resistance, etc., to reduce water loss and precision swelling Performance, effect of increasing concentration

Active Publication Date: 2022-03-25
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the materials for preparing hydrogel mainly include synthetic polymers and natural polymers. Synthetic polymer materials have some obvious disadvantages, such as: poor biocompatibility, high chronic toxicity, strong immune resistance, insufficient mechanical strength and toughness, and Natural polymers have abundant sources, high degradability and good biocompatibility, and are the main raw materials for preparing hydrogels
As an active natural polymer, cellulose is widely used in hydrogels, but the drug loading of current cellulose hydrogel materials is too low. The swelling performance is too good and the surrounding normal tissue is squeezed, which limits its application

Method used

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  • A composite hydrogel material for hemostasis and healing promotion and its preparation method and application
  • A composite hydrogel material for hemostasis and healing promotion and its preparation method and application
  • A composite hydrogel material for hemostasis and healing promotion and its preparation method and application

Examples

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Embodiment 1

[0051] A composite hydrogel material for hemostasis and healing promotion, which is composed of tea microcrystalline cellulose and fenugreek gum.

[0052] A preparation method of a composite hydrogel material for hemostasis and healing, comprising the following steps:

[0053] 1) Weigh 0.50g of tea cellulose into a test tube, add 10.0g of [AMIm]Cl ionic liquid, and then keep stirring in a constant temperature magnetic stirring oil bath at 100°C at a stirring speed of 200rpm / min for 3h to obtain tea microcrystals Cellulose solution;

[0054] 2) Add 0.3 g of fenugreek gum to the tea microcrystalline cellulose solution, and continue stirring at a stirring speed of 200 rpm / min at 100°C for 5 hours to obtain a mixed solution A;

[0055] 3) Take the test tube out of the oil bath and cool it to room temperature, then add isopropanol aqueous solution (the volume ratio of isopropanol to water is 1:1) into the test tube, soak for 10d, when the composite hydrogel is observed When the v...

Embodiment 2

[0057] A composite hydrogel material for hemostasis and healing promotion, which is composed of corn microcrystalline cellulose and fenugreek gum.

[0058] A preparation method of a composite hydrogel material for hemostasis and healing, comprising the following steps:

[0059] 1) Weigh 0.50 g of corn microcrystalline cellulose into a test tube, add 10.0 g of [AMIm]Cl ionic liquid, and then keep stirring in a constant temperature magnetic stirring oil bath at a stirring speed of 180 rpm / min for 2 hours at 95°C to obtain corn Microcrystalline cellulose solution;

[0060] 2) Add 0.1 g of fenugreek gum to the corn microcrystalline cellulose solution, and continue stirring at a stirring speed of 180 rpm / min at 100°C for 4 hours to obtain a mixed solution A;

[0061] 3) Take the test tube out of the oil bath and cool it to room temperature, then add isopropanol aqueous solution (the volume ratio of isopropanol to water is 1:1) into the test tube, soak for 10d, when the composite h...

Embodiment 3

[0063] A composite hydrogel material for hemostasis and healing promotion, which is composed of oat microcrystalline cellulose and fenugreek gum.

[0064] A preparation method of a composite hydrogel material for hemostasis and healing, comprising the following steps:

[0065] 1) Weigh 0.50 g of oat microcrystalline cellulose into a test tube, add 10.0 g of [AMIm]Cl ionic liquid, and then keep stirring in a constant temperature magnetic stirring oil bath at a stirring speed of 100 rpm / min for 2 h at 102°C to obtain oat microcrystalline cellulose. Crystalline cellulose solution;

[0066] 2) Add 0.4 g of fenugreek gum to the oat microcrystalline cellulose solution, and continue to stir at 100 rpm / min for 4 hours at 100°C to obtain a mixed solution A;

[0067] 3) Take the test tube out of the oil bath and cool it to room temperature, then add isopropanol aqueous solution (the volume ratio of isopropanol to water is 1:1) into the test tube, soak for 14d, when the composite hydrog...

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Abstract

The invention discloses a composite hydrogel material for hemostasis and healing promotion, a preparation method and application thereof. The composite hydrogel prepared by the present invention has precise and suitable swelling properties, and it can maintain a stable structure in water for a long time, and the adsorption test for methylene blue shows that its equilibrium adsorption capacity can reach 6.9mg / g, which shows that the present invention The invented composite hydrogel material has very excellent drug-loading capacity, and has a good slow-release effect on methylene blue. At the same time, different drugs can be embedded in the composite hydrogel according to the needs, and the drug can pass through the diffusion and hydrogel. The degradation is slow and sustained release. The hydrogel can accelerate hemostasis, promote wound healing or reduce the pain of the wound, and the hydrogel will not interact with the wound, the exudate of the wound can be discharged through the hydrogel, and its transparency is convenient for patients and doctors to see through. Use the gel to observe the wound healing at any time.

Description

technical field [0001] The invention belongs to the field of composite materials, and in particular relates to a composite hydrogel material for hemostasis and healing promotion, as well as its preparation method and application. Background technique [0002] Medical dressing is a kind of medical material that temporarily covers various wounds and wound surfaces. Its main function is to quickly stop bleeding and provide an environment conducive to wound healing: protect the wound, control the exudate of the wound, and avoid bacteria and dust pollution. An ideal medical dressing should have the following functions: (1) good biocompatibility, which can prevent excessive loss of water and body fluids; (2) adhere well to the wound surface, and the dressing will not stick to the wound when it is removed, and can Avoid secondary damage caused by changing dressings; (3) resist the invasion of bacteria and harmful particles and prevent infection; (4) have suitable swelling properti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L1/04C08L5/00A61L26/00
CPCC08J3/075A61L26/0052A61L26/008A61L26/0066A61L26/0061A61L26/009C08J2301/04C08J2405/00A61L2300/602A61L2300/412C08L1/04C08L5/00
Inventor 廖文镇邓玉娣曹翯翯黄锦钰孙素霞
Owner SOUTHERN MEDICAL UNIVERSITY