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Skeleton type vitamin C sustained-release pellet and preparation method thereof

A technology for slow-release pellets and vitamins, which can be used in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. It can solve the problems of uneven particle size, low material yield, and dust development. , to achieve the effect of no dust flying, reducing operation time and beautiful appearance

Inactive Publication Date: 2020-03-27
JIANGSU ALAND NOURISHMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the size of the particles produced by the wet granulator is not uniform, the material yield is low in the process of soft material screening, and dust is generated during the granulation process, etc.

Method used

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  • Skeleton type vitamin C sustained-release pellet and preparation method thereof
  • Skeleton type vitamin C sustained-release pellet and preparation method thereof
  • Skeleton type vitamin C sustained-release pellet and preparation method thereof

Examples

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Effect test

preparation example Construction

[0021] A method for preparing skeleton-type vitamin C sustained-release pellets, characterized in that it comprises the following steps:

[0022] (1) Put the container containing the formulated amount of vegetable oil in a water bath at a certain temperature, add the waxy matrix agent one by one and mix and stir until the waxy matrix agent is completely melted and stir evenly, then add functional ingredients vitamin C and binder and stir evenly, Put it in the refrigerator to solidify, take it out and pulverize it, and pass it through a sieve with a certain mesh size to obtain premix one;

[0023] (2) Mix the above premix 1 with diluent and insoluble skeleton agent to prepare premix 2; dissolve the antioxidant in the formula amount in the wetting agent to prepare a solution with a certain concentration; add the above solution to the premix In material 2, stir and mix evenly to obtain a soft material;

[0024] (3) Put the above soft material into the extruder and extrude throug...

Embodiment 1

[0027] The formula component of the present invention sees figure 1 . Its preparation method is as follows:

[0028] (1) Put the container containing 2g of vegetable oil and olive oil in a water bath at 80°C, gradually add 80g of waxy framework agent stearic acid, mix and stir until the stearic acid is completely melted, then add 600g of functional ingredient vitamin C and stir evenly , solidified in a refrigerator at -20°C, taken out and pulverized, and passed through a 60-mesh sieve to obtain a premix 1;

[0029] (2) Mix the above premix 1 with 317.1 g of diluent microcrystalline cellulose to prepare premix 2; dissolve 0.9 g of antioxidant tartaric acid in wetting agent water to prepare a solution with a mass volume ratio of 0.45%; Add the above solution into premix 2, stir and mix evenly to obtain a soft material;

[0030] (3) Add the above-mentioned soft materials into the extruder, extrude through the sieve plate of the extruder, the aperture of the sieve plate is 0.9m...

Embodiment 2

[0033] The formula component of the present invention sees figure 2 . Its preparation method is as follows:

[0034] (1) Put the container containing 2g of vegetable oil and olive oil in a water bath at 80°C, add 50g of the waxy framework agent stearic acid one by one, mix and stir until all the stearic acid is melted, then add 600g of functional ingredient vitamin C and stir evenly , solidified in a refrigerator at -20°C, taken out and pulverized, and passed through a 60-mesh sieve to obtain a premix 1;

[0035] (2) Mix the above premix 1 with 297.1g diluent microcrystalline cellulose and 50g insoluble skeleton ethyl cellulose to prepare premix 2; dissolve 0.9g antioxidant tartaric acid in wetting agent water to prepare A solution with a mass-to-volume ratio of 0.45%; add the above-mentioned solution to premix 2, stir and mix evenly to obtain a soft material;

[0036] (3) Add the above-mentioned soft materials into the extruder, extrude through the sieve plate of the extrud...

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Abstract

The invention discloses a skeleton type vitamin C sustained-release pellet and a preparation method thereof. The pellet is composed of vitamin C, a skeleton agent, a diluent, an antioxidant, vegetableoil, a wetting agent and an optional adhesive. The pellet comprises the following components in percentage by weight: 40-65% of vitamin C, 3-40% of the skeleton agent, 1-60% of the diluent, 0.01-2% of the antioxidant, 0.1-1% of the vegetable oil, 0-6% of the adhesive and the balance of the wetting agent. The skeleton-type vitamin C sustained-release pellet is prepared in one step by an extrusionspheronization method, and is simple in technological operation, good in reproducibility, free of dust flying in the process, high in finished product yield and attractive in appearance.

Description

technical field [0001] The invention relates to the field of sustained-release preparation of vitamin C, in particular to a skeleton vitamin C sustained-release pellet and a preparation method thereof. Background technique [0002] Vitamin C, also known as "ascorbic acid", is one of the essential nutrients for the human body. It can enhance immunity, promote wound and surgical incision healing, reduce blood lipids, prevent cancer, resist oxidation, and have whitening effects. Humans cannot synthesize vitamin C themselves, and can only obtain this substance necessary for maintaining the body from the diet. At present, there are many vitamin C preparations on the market, but vitamin C is quickly absorbed by the small intestine after oral administration, and the stable concentration in the body is 10-15mg / l. The original form is excreted from the body. When taking large doses of vitamin C clinically, patients often need to take it frequently. The patient's compliance is poor, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/375A61K47/12A61K47/10A61P37/04A61P17/02A61P3/06A61P35/00A61P39/06A61P17/00
CPCA61K9/1617A61K31/375A61P3/06A61P17/00A61P17/02A61P35/00A61P37/04A61P39/06
Inventor 张榕陈中科张国栋夏旭东张勇常俊
Owner JIANGSU ALAND NOURISHMENT
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