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Water-soluble chitosan derivative and preparation method thereof

A technology of water-soluble chitosan and chitosan derivatives, which is applied in the field of water-soluble chitosan derivatives and its preparation, can solve the problems of chitosan being insoluble in water, etc., and achieve the effect of expanding the application field

Inactive Publication Date: 2020-03-27
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problem of insoluble in water in using chitosan, provide a kind of chitosan derivative with water solubility and preparation method thereof

Method used

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  • Water-soluble chitosan derivative and preparation method thereof
  • Water-soluble chitosan derivative and preparation method thereof

Examples

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example 1

[0013] Weigh 5 parts of chitosan, each 1 gram, and disperse them in 5 three-necked bottles each containing 10 milliliters of isopropanol, place on a magnetic stirrer and stir and swell at room temperature for 30 minutes, then add dimethylformamide 5 milliliters, then add 25 milliliters of 40% NaOH solution, after stirring at room temperature for 3 hours, weigh chloroacetic acid respectively, make chitosan and chloroacetic acid mass ratio be 1: 1, 1: 2, 1: 3, 1: 4. 1:5, respectively added to the above reaction solution, and then transferred to a water bath at 60°C to reflux at a constant temperature for 8 hours, then poured into a beaker and cooled. Take a small amount of solution to see if it can be completely dissolved, if not, continue the reaction until it is completely dissolved. After the reaction is complete, add glacial acetic acid to the solution to adjust the pH value to 7.0, wash with absolute ethanol and acetone solution three times, filter with suction, stir and di...

example 2

[0015] Weigh 5 parts of chitosan, each 1 gram, and disperse them in 5 three-necked bottles each containing 10 milliliters of isopropanol, place them on a magnetic stirrer and stir and swell at room temperature for 30 minutes, then add dimethyl formaldehyde Add 5 ml of amide, then add 25 ml of 40% NaOH solution, stir at room temperature for 2 hours, weigh chitosan and chloroacetic acid in a mass ratio of 1:2, add to the reaction solution, and then transfer to a water bath at 60°C After reflux at constant temperature for 2 hours, 4 hours, 6 hours, 8 hours, and 10 hours, pour it into a beaker and cool it down. Take a small amount of solution to see if it can be completely dissolved, if not, let it continue to react until it is completely dissolved. After the reaction is complete, add glacial acetic acid to the solution to adjust the pH value to 7.0, wash with absolute ethanol and acetone solution three times, filter with suction, stir and dissolve the obtained powder with deioniz...

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Abstract

The invention discloses a water-soluble chitosan derivative and a preparation method thereof, wherein the chitosan derivative is water-soluble chitosan and is prepared from chitosan and chloroacetic acid through a carboxylation reaction according to a molar ratio of the chloroacetic acid to the hydroxyl on the chitosan of 1:1-5:1. According to the invention, the method is mild in reaction condition, simple and safe to operate and easy to accept by researchers; the chitosan derivative obtained by the reaction has good water solubility; by controlling the reaction time, the molar ratio and otherfactors, the chitosan derivative can be dissolved in deionized water at room temperature, and the water solubility can be greatly changed along with different reaction conditions, so that the application field of chitosan is expanded, and the chitosan has potential application value in the fields of injectable drug sustained-release carriers, heavy metal ion adsorption and the like.

Description

technical field [0001] The invention relates to a water-soluble chitosan derivative and a preparation method thereof. Background technique [0002] Chitosan is a natural alkaline polysaccharide derived from the shell of crustaceans, which has good biocompatibility and biodegradability. Chitosan is the product of deacetylation of chitin. It is widely distributed and cheap. It degrades into non-toxic small molecule glucosamine in the form of small molecules. It is the only natural base polysaccharide obtained so far. Chitosan has a bactericidal effect, can highly kill the parasitic bacteria of mammalian cells, and has low toxicity to mammalian cells. Chitosan has good biocompatibility and helps wound healing. Chitosan is soluble in dilute organic acid solutions, but insoluble in water, which limits the application of chitosan. After chitosan is modified, chitosan derivatives with good water solubility can be obtained. These chitosan derivatives are widely used in medicine a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
CPCC08B37/003
Inventor 李征征李进赵梓年
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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