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Organic acid property detection agent and method, test paper, preparation method and application

A technology for detecting test strips and detection agents, which is applied in organic chemistry, analysis by chemical reaction of materials, and material analysis by observing the influence of chemical indicators. It can solve problems such as lack of strong acid gas detection, and achieve easy Observation, synthesis method is simple, the effect of early warning leakage

Inactive Publication Date: 2022-04-15
南京艾姆材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The object of the present invention is to provide a kind of organic acid detection agent and method, test paper and preparation method and application, to solve the defect that lacks to strong acid gas detection in the prior art

Method used

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  • Organic acid property detection agent and method, test paper, preparation method and application
  • Organic acid property detection agent and method, test paper, preparation method and application
  • Organic acid property detection agent and method, test paper, preparation method and application

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preparation example Construction

[0035] A method for preparing an organic acid detection agent, said method comprising the steps of:

[0036] Under the action of p-toluenesulfonic acid, 5-bromo-isophthalaldehyde is condensed with neopentyl glycol, and the corresponding 5-bromo-isophthalaldehyde is obtained through a chromatographic column ,3-dioxane compound;

[0037] Wherein, the feeding ratio of 5-bromo-isophthalaldehyde and neopentyl glycol is 1:1~5;

[0038] Synthesize 1,3,5-tris(bromophenyl)-pyrazine and bipinacol borate under the action of an iron catalyst to synthesize the corresponding 1,3,5-tris(pinacol borate)- pyrazine;

[0039] Wherein, the iron catalyst includes 1,1'-bisdiphenylphosphinoferrocene.

[0040] The obtained 1,3,5-tris(pinacol borate)-pyrazine and 5-bromo-isophthal-2-5,5-dimethyl-1,3-dioxane compound in palladium catalyst The corresponding 1,3,5-tris(5,5-dimethyl-1,3-dioxane biphenyl)-pyrazine can be obtained by carbon-carbon coupling under the action.

[0041] Wherein, the pallad...

Embodiment 1

[0053] (1) Preparation of intermediate 5-bromo-resorcinol-5,5-dimethyl-1,3-dioxane ( figure 1 )

[0054] Weigh 5-bromo-isophthalaldehyde (0.1mmol) and neopentyl glycol (injection amounts are 0.1, 0.2, 0.3, 0.4, 0.5mmol respectively) and put it into a single-necked bottle with 50mL of toluene solvent, and quickly add Catalytic amount (0.005mmol) of p-toluenesulfonic acid was heated to 120 degrees Celsius and continued to reflux for 12 hours. After the reaction, the reaction solution was cooled. The toluene in the reaction bottle was removed by rotary evaporation, dissolved in dichloromethane, mixed with silica gel, dry-loaded, and purified by column using petroleum ether as a developer to obtain the intermediate intermediate 5-bromo-resorcin-5, For 5-dimethyl-1,3-dioxane, the yields obtained by the corresponding dosages were 30%, 50%, 82%, 85% and 91%.

[0055] (2) Preparation of 1,3,5-three (pinacol borate)-pyrazine ( figure 1 )

[0056]Put 1,3,5-tris(bromophenyl)-pyrazin...

Embodiment 2

[0060] Preparation method of organic acidic solvent test paper with 1,3,5-tris(5,5-dimethyl-1,3-dioxanebiphenyl)-pyrazine as active ingredient (including models I, II and III )

[0061] 1,3,5-tris(5,5-dimethyl-1,3-dioxane biphenyl)-pyrazine (0.1mmol) and 1,4-butanediol (injecting amounts of 0.1, 0.2,0.3mmol) into the single-necked bottle that the mixture of polytetrahydrofuran diol and polyethylene oxide diol is housed, heated to 70 degrees Celsius, reacted for 2 hours. Put 3,3'-dichloro-4,4'-diphenylmethanediamine (0.1 / 0.2 / 0.3mmol) into the above one-necked bottle, and continue to react for 8 minutes. After the reaction is completed, spread the reaction solution evenly on the On the original pulp paper, dry for 24 hours to obtain three models ( I, II and III) organic acid solvent detection test paper.

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Abstract

The invention discloses an organic acid property detection agent and method, test paper, a preparation method and application, the structural formula is as follows: the parent structure of the molecule is a 1, 3, 5-terphenyl-triazine structure, the peripheral structure of the molecule is 5, 5-dimethyl-1, 3-dioxane, and the 5, 5-dimethyl-1, 3-dioxane group can adjust the solubility of the molecule. The molecules are extremely sensitive to acid molecules and can be rapidly combined with the acid molecules, so that the conjugacy of the molecules is changed, and a yellow compound is generated. A test strip is obtained by loading the molecules in primary pulp paper, and can be applied to early alarm of leakage of organic acid solvents trifluoroacetic acid and trifluoromethanesulfonic acid in organic synthesis laboratories and chemical plants.

Description

technical field [0001] The invention relates to the field of chemical reagents, in particular to an organic acid detection agent and method, test paper, a preparation method and application. Background technique: [0002] Strong organic acids such as trifluoroacetic acid and trifluoromethanesulfonic acid are widely used as medicines, pesticide intermediates, biochemical reagents, and organic synthesis reagents. As extremely strong protonic acids, they are widely used as catalysts for alkylation, acylation, and olefin polymerization of aromatic compounds; as solvents, they are excellent solvents for fluorination, nitration, and halogenation reactions. But these two types of organic acids have obvious health hazards. Inhalation or absorption through the skin can be harmful to the body. At the same time, it has a strong stimulating effect on eyes, mucous membranes, respiratory tract and skin. For example, inhalation may lead to throat and bronchial spasms, inflammation, edem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/80G01N21/78C07D405/14
Inventor 彭雨新郑玮
Owner 南京艾姆材料科技有限公司
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