Cyclic dinucleotide analogues, pharmaceutical composition of analogues and applications of analogues and pharmaceutical composition

A technology of cyclic dinucleotides and analogues, applied in drug combinations, sugar derivatives, sugar derivatives, etc.
CN110938104APending Publication Date: 2020-03-31SHANGHAI DE NOVO PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI DE NOVO PHARMA
Publication Date
2020-03-31

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Abstract

The invention discloses cyclic dinucleotide analogues, a pharmaceutical composition of the analogues and applications of the analogues and the pharmaceutical composition. The cyclic dinucleotide analogs (I), an isomer, prodrug, stable isotope derivative or pharmaceutically acceptable salt of the analogs have a structure shown in the specification. The cyclic dinucleotide analogs provided by the invention can be used as regulators of stimulator of interferon genes (STIG) and related signaling pathways, and can effectively treat and / or alleviate multiple types of diseases, including but not limited to malignant tumors, inflammation, autoimmune diseases and infectious diseases; and in addition, the STING regulators can also be used as vaccine adjuvants.
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Description

technical field

[0001] The invention relates to a cyclic dinucleotide analogue, its pharmaceutical composition and its application as a STING agonist and activation of the STING pathway. Background technique

[0002] Interferon gene stimulator STING (Stimulator of Interferon Genes), also known as T1MEM173, MITA, MPYS and ERIS, is an important signaling molecule in innate immune signaling. The protein encoded by this gene contains 5 transmembrane structures. It plays an important regulatory role in the process of immune response related to bacterial infection. As a pattern recognition receptor, STING can detect and recognize exogenous nucleic acid in the cytoplasm and activate signal transduction pathways related to type I interferon responses. In addition, studies have shown that STING participates in the regulation of apoptosis signals by interacting with type II major histocompatibility complex (MHCII). Studies of human tumors with spontaneous T cell infiltration have sh...

Claims

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