Medical hydrogel and preparation method thereof

A hydrogel, medicinal technology, applied in the field of medical materials, can solve the problems of short action time, high administration frequency, high power density damage to surrounding healthy tissue, etc., to improve antibacterial performance, not easy to dehydrate, and improve drug resistance. Effect

Active Publication Date: 2020-04-07
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The currently developed antibacterial nanoparticle (such as nanosilver) solution is difficult to stay on the wound for a long time due to its liquid state, short...

Method used

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  • Medical hydrogel and preparation method thereof
  • Medical hydrogel and preparation method thereof
  • Medical hydrogel and preparation method thereof

Examples

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Embodiment 1

[0043]As a kind of medicinal hydrogel according to the embodiment of the present invention, the medicinal hydrogel is composed of methacrylated gelatin (Gel-MA), polydopamine hyaluronic acid (HA-DA) and the first nanoparticle (β-CD-GO-BNN6) is obtained by uniform dispersion of raw materials and cross-linking reaction;

[0044] The molecular weight of the methacrylated gelatin is greater than 3500Da, the molecular weight of the polydopamine hyaluronic acid is greater than 10000Da, the weight ratio of the methacrylated gelatin and the polydopamine hyaluronic acid is 3:1, and the first The weight of a nanoparticle accounts for 0.0533% of the total weight of the methacrylated gelatin and polydopamine hyaluronic acid;

[0045] The preparation method of the first nanoparticle comprises the following steps:

[0046] (1) Disperse graphene oxide (GO) in water, add β-cyclodextrin (β-CD) and stir at 20-30°C for 12 hours, then separate solid-liquid to collect solid precipitate and wash t...

Embodiment 2

[0060] As a medicinal hydrogel implemented in the present invention, the only difference between this example and Example 1 is that the weight of the first nanoparticles accounts for the total weight of the methacrylated gelatin and polydopamine hyaluronic acid 0.0667% of.

Embodiment 3

[0062] As a medicinal hydrogel implemented in the present invention, the only difference between this example and Example 1 is that the weight of the first nanoparticles accounts for the total weight of the methacrylated gelatin and polydopamine hyaluronic acid 0.133%.

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Abstract

The invention provides a medical hydrogel and a preparation method thereof. The medical hydrogel is obtained by uniformly dispersing raw materials including methacrylate gelatin, polydopamine hyaluronic acid and first nanoparticles and carrying out a cross-linking reaction, wherein the weight ratio of the methacrylate gelatin to the polydopamine hyaluronic acid is (1-5): 1, and the first nanoparticles account for 0.05%-0.2% of the total weight of the methacrylate gelatin and the polydopamine hyaluronic acid; the first nanoparticles are obtained by dispersing beta-cyclodextrin modified grapheneoxide and N, N'-di-sec-butyl-N, N'-dinitroso-1, 4-phenylenediamine into an organic solvent according to a weight ratio of 1: (1.5-2.5), stirring and reacting for 8-20 hours in a dark place and then standing. The medical hydrogel has lasting antibacterial performance, improves drug resistance of antibacterial components, provides proper permeability for wound healing, enables a wound to be not prone to dehydration, has injectability and viscosity, and has the functions of being attached to the wound along with change of the shape of the wound and stopping bleeding.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a medicinal hydrogel and a preparation method thereof. Background technique [0002] Bacterial infection is a very common problem in open wounds. With the discovery and application of antibiotics, bacterial infection has been effectively suppressed. However, long-term use of antibiotics may lead to drug resistance in some bacteria, greatly reducing the treatment effect of infection. Photothermal therapy has attracted extensive attention in recent years because of its broad-spectrum antibacterial effect, which can kill bacteria by generating local high temperature generated by photosensitizers under near-infrared (NIR) light radiation. The currently developed antibacterial nanoparticle (such as nanosilver) solution is difficult to stay on the wound for a long time due to its liquid state, short action time, high frequency of administration, high power density and long-t...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0038A61L26/0023A61L26/0004A61L26/0066A61L26/0061A61L26/008A61L2400/06A61L2400/04A61L2300/108A61L2300/624C08L5/08
Inventor 郭瑞黄少珊
Owner JINAN UNIVERSITY
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