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Mouthwash for balancing oral flora and preparation method thereof

A technology for mouthwash and oral cavity, which is applied in the field of mouthwash for balancing oral flora and its preparation, which can solve problems such as the inability to adjust the oral microbial environment and halitosis, and achieve the effect of improving the oral ecological environment, good sterilization and wound healing , the effect of balancing oral flora

Pending Publication Date: 2020-04-14
合肥赛为智慧医疗有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, mouthwash can only improve breath in the short term, but cannot adjust the microbial environment of the oral cavity, and the problem of bad breath has not been solved

Method used

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  • Mouthwash for balancing oral flora and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A mouthwash for balancing oral flora, its raw materials include by weight percentage: 1% chitosan / copper chlorophyllin sodium salt complex, 0.6% catechin, 2% β-cyclodextrin, 5% Span 80, Xylitol 5%, essence 1.2%, glycerin 10%, ethanol 25%, sodium benzoate 0.5%, the rest is water;

[0019] Wherein, in the preparation process of the chitosan / copper chlorophyllin sodium salt complex, the copper chlorophyllin sodium salt is dispersed in the chitosan acetic acid aqueous solution, and then spray-dried to obtain the chitosan / copper chlorophyllin sodium salt complex.

[0020] The preparation method of the above-mentioned mouthwash for balancing oral flora comprises the following steps: adding Span 80, xylitol, essence, glycerin, ethanol, sodium benzoate into water and mixing, then adding β-cyclodextrin and catechin and mixing , and finally add chitosan / copper chlorophyllin sodium salt complex, mix well, filter, and sterilize to obtain a mouthwash that balances oral flora.

Embodiment 2

[0022] A mouthwash for balancing oral flora, its raw materials include by weight percentage: chitosan / copper chlorophyllin sodium complex 1.5%, catechin 0.4%, β-cyclodextrin 3%, Tween 20 3%, Xylitol 8%, essence 0.8%, glycerin 15%, ethanol 15%, sodium benzoate 2%, the rest is water;

[0023] Wherein, in the preparation process of the chitosan / copper chlorophyllin sodium salt complex, the copper chlorophyllin sodium salt is dispersed in the acetic acid aqueous solution of chitosan, and then spray-dried to obtain the chitosan / copper chlorophyllin sodium salt complex, wherein, The injection port temperature of the spray drying is 140°C, and the flow rate of the drying air is 0.6m 3 / min, the material flow rate is 3ml / min, the atomization pressure is 140KPa, the weight ratio of chitosan and copper chlorophyllin sodium salt is 10:2, the particle size of chitosan / copper chlorophyllin sodium salt complex is less than 1μm, and the acetic acid aqueous solution The volume fraction of ac...

Embodiment 3

[0026] A mouthwash for balancing oral flora, its raw materials include by weight percentage: chitosan / copper chlorophyllin sodium salt complex 1.1%, catechin 0.55%, β-cyclodextrin 2.2%, Span 80 4.5%, Xylitol 6%, essence 1.1%, glycerin 11%, ethanol 23%, sodium benzoate 1%, the rest is water;

[0027] Wherein, in the preparation process of the chitosan / copper chlorophyllin sodium salt complex, the copper chlorophyllin sodium salt is dispersed in the acetic acid aqueous solution of chitosan, and then spray-dried to obtain the chitosan / copper chlorophyllin sodium salt complex, wherein, The injection port temperature of the spray drying is 130°C, and the flow rate of the drying air is 0.8m 3 / min, the material flow rate is 2ml / min, the atomization pressure is 160KPa, the weight ratio of chitosan and copper chlorophyllin sodium salt is 10:1, the particle size of the chitosan / copper chlorophyllin sodium salt complex is less than 1μm, and the acetic acid aqueous solution The volume f...

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Abstract

The invention discloses mouthwash for balancing oral flora. The mouthwash comprises the following raw materials by weight percentage: 1-1.5% of a chitosan / sodium copper chlorophyllin compound, 0.4-0.6% of catechinic acid, 2-3% of beta-cyclodextrin, 3-5% of a surfactant, 5-8% of xylitol, 0.8-1.2% of essence, 10-15% of a humectant, 15-25% of ethanol, 0.5-2% of a preservative and the balance water. The invention also discloses a preparation method of the mouthwash for balancing oral flora. Through mutual cooperation of all the substances, the mouthwash can balance oral flora and improve the oralecological environment, also can promote oral wound healing, control decayed teeth and refresh breath, and has no toxic or side effect.

Description

technical field [0001] The invention relates to the technical field of mouthwash, in particular to a mouthwash for balancing oral flora and a preparation method thereof. Background technique [0002] Halitosis can be divided into non-pathological halitosis and pathological halitosis. Pathological halitosis can be divided into oral halitosis and non-oral halitosis according to its source. According to statistics, 80-90% of halitosis belongs to oral halitosis. Most halitosis is related to oral diseases and the microbial environment of the oral cavity. [0003] Although using a toothbrush can remove some tartar and plaque, it is difficult for some people who lack motivation to persist. Mouthwash may be an ideal alternative for this group of people. And after brushing, after the plaque biofilm has been destroyed, using mouthwash is more effective in controlling plaque than brushing alone. However, mouthwash can only improve breath in the short term, but cannot regulate the ...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61K8/34A61K8/49A61K8/58A61K31/722A61K33/34A61K31/724A61Q11/00A61P31/04A61P31/02A61P1/02A61K31/047A61K31/353A61K31/409
CPCA61K8/736A61K8/494A61K8/58A61K8/498A61K8/345A61K8/738A61Q11/00A61K31/722A61K31/409A61K33/34A61K31/353A61K31/047A61K31/724A61P1/02A61P31/02A61P31/04A61K2800/5922A61K2300/00
Inventor 宋海威赵瑜盛恩菊陈洋赵佳佳王晗
Owner 合肥赛为智慧医疗有限公司
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