Process method for preparing cyclopropyl methyl ketone

Abstract

The invention belongs to the technical field of organic synthesis, and particularly relates to a process method for preparing cyclopropyl methyl ketone. The used equipment comprises a shell, a reaction tank and a rotating shaft, wherein the reaction tank is fixedly connected to the interior of the shell, the upper surface of the shell is fixedly connected with a motor, the output shaft of the motor is fixedly connected with a rotating shaft, the rotating shaft sequentially penetrates downwards through the shell and the upper wall of the reaction tank and extends into the reaction tank, and a first baffle and a second baffle are respectively arranged below the rotating shaft. In the prior art, the layered solutions flow downwards as a whole, and part of the different layered solutions are mixed again. According to the method of the invention, the problem in the prior art is effectively solved, the automatic separation and collection of the layered solutions is achieved, the separated solutions are high in purity, water and hydrochloric acid can be separated and collected and can be directly used for the second time, and the raw material cost and the separation cost are reduced.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, in particular to a process for preparing cyclopropyl methyl ketone. Background technique [0002] Cyclopropyl methyl ketone is an important organic raw material and intermediate. In medicine, it is mainly used in the synthesis of anti-AIDS drugs Efluviren and Ilremin. In pesticides, it is mainly used in the fungicide Azuridine Synthesis of amines and cyproconazole. [0003] In the prior art, on the one hand, the raw material for the traditional production of cyclopropyl methyl ketone adopts acetyl n-propanol, which is chlorinated by adding hydrochloric acid, and then carries out ring closure reaction with alkali to obtain the organic layer cyclopropyl methyl ketone. The reaction method Complicated and costly; on the other hand, the layered solution needs to be discharged sequentially through the pipe, because the overall downward flow of the layered solution will cause partial mixing b...

AI Technical Summary

Problems solved by technology

[0005] In order to make up for the deficiencies of the prior art and solve one aspect of the prior art, the raw material for the traditional production of cyclopropyl methyl ketone is acetyl n-propanol, which is chlorinated by adding hydrochloric acid, and then undergoes a cyclization reaction with an alkali to obtain an organic layer ring Propyl methyl ketone, the reaction method is complicated, and the cost is high; The purity of the separated and collected organic layer 5-chloro-2-pentanone is relatively low, which increases the workload of distillation purification and purification costs. The present invention proposes a process for preparing cyclopropyl methyl ketone

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