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Intelligent cerebral function oxyhemoglobin saturation monitoring measurement simulation algorithm

A brain function and saturation technology, applied in diagnostic recording/measurement, medical science, diagnostic signal processing, etc., can solve the problems of error-prone readings, low resolution, lossy detection, etc., to shield noise interference and avoid noise Error, effect of medium uniformity

Inactive Publication Date: 2020-04-21
杭州传一科技有限公司
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  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

In the past, traditional functional index detection methods were mostly limited to destructive detection, or the detection resolution was not high, and could not provide effective monitoring capabilities for blood oxygen indicators at specific locations.
[0004] When evaluating the physiological function of red blood cells, in pulse oximeters, readings are prone to errors due to hypotension, hypothermia, abnormal EMG and body movement, and insufficient effective scattering radius caused by blood being a very high concentration medium
The factors that affect the monitoring of blood oxygen saturation of brain function mainly come from the interference of head movement, the noise introduced by the signal processing channel, the noise introduced by the optical fiber sensor itself, the sensitivity drift of the detection instrument and the lack of stability of photoelectric conversion.

Method used

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  • Intelligent cerebral function oxyhemoglobin saturation monitoring measurement simulation algorithm
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  • Intelligent cerebral function oxyhemoglobin saturation monitoring measurement simulation algorithm

Examples

Experimental program
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Embodiment 1

[0050] An intelligent cerebral function blood oxygen saturation monitoring and measurement simulation algorithm provided in this embodiment includes the following steps:

[0051]1) Construct a measurement simulation space. The simulation space is composed of multiple three-dimensional Cartesian coordinate system voxel grids, the number is 915×535×535, and the three-dimensional size of the grid is length×width×height=17mm×11mm×11mm;

[0052] 2) Use detectors to measure the distributed optical properties of each tissue surface element in the simulated space, and the number of detection points is recorded as the vector Φ=(Φ 1 ,Φ 2 ,Φ 3 ,...,Φ M ) T , assigning the optical property as the light absorption coefficient light scattering coefficient The light scattering anisotropy m, the volume of the element is 25μm×25μm×25μm; the measurement condition is to measure the photoacoustic velocity of the flowing blood with 21 wavelengths from 700nm to 900nm under the pulse flow rat...

Embodiment 2

[0081] The difference between this embodiment and Embodiment 1 is that the number of voxel grids in the three-dimensional Cartesian coordinate system is 800×500×500, and the three-dimensional size of the voxel grids: length×width×height=15mm×10mm×10mm; The volume is 20 μm×20 μm×20 μm.

[0082] The detector measurement condition in step 2) is to measure the photoacoustic velocity of the flowing blood with 21 wavelengths from 700nm to 900nm at a beat frequency of 60bpm and a step of 10nm under pulse flow.

Embodiment 3

[0084] The difference between this embodiment and Embodiment 1 and Embodiment 2 is that the number of voxel grids in the three-dimensional Cartesian coordinate system is 1000×550×550, and the three-dimensional size of the voxel grids: length×width×height=20mm×12mm× 12mm; the volume of the element is 30μm×30μm×30μm.

[0085] The detector measurement condition in step 2) is to measure the photoacoustic velocity of the flowing blood with 21 wavelengths from 700nm to 900nm at a beat frequency of 80bpm and a step of 15nm under pulse flow.

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Abstract

The invention provides an intelligent cerebral function oxyhemoglobin saturation monitoring measurement simulation algorithm. The algorithm comprises the following steps: constructing a measurement simulation space; measuring distribution optical characteristics and spatial distribution, and calculating energy deposition according to the spatial distribution; obtaining an initial overpressure source under a thermal elastic stress constraint condition; when the laser pulse length is less than the thermal relaxation time, the medium is uniform and the sound velocity is constant, obtaining a photo-acoustic velocity wavelength propagation formula; carrying out fitting by adopting a Green function to obtain a positive solution of the photo-acoustic velocity wavelength; modeling a frequency response curve of a transducer as a Gaussian function, and constructing a mapping model between the photo-acoustic velocity with wavelength limitation and the number of detection points to obtain an optical distribution theoretical value model; and solving an optimized value of the minimum value of an error function and a cerebral function oxyhemoglobin saturation monitoring measurement reference standard. According to the invention, an algorithm using the Green function and Monte Carlo radiation flux to simulate the optical parameter distribution of reconstructed tissues is adopted, and an intelligent cerebral function oxyhemoglobin saturation monitoring measurement standard is effectively constructed.

Description

technical field [0001] The invention belongs to the technical field of medical equipment, and in particular relates to an intelligent cerebral function blood oxygen saturation monitoring and measurement simulation algorithm. Background technique [0002] Near-infrared spectroscopy has been developed in recent years to provide a portable, real-time, continuous, easy-to-operate, and relatively inexpensive non-invasive detection method for clinical practice. Clinically, the cerebral oximeter is an ideal monitoring instrument for obtaining information on cerebral blood oxygen reserve, which can provide neurosurgeons with a non-invasive observation window of intracranial cerebral oxygen level. Especially when the blood circulation stops, the normal work of many monitoring instruments will have certain difficulties, but the cerebral oximeter can still work as usual, so the cerebral oximeter can be widely used in various occasions of cerebral blood oxygen monitoring. [0003] Red ...

Claims

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Application Information

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IPC IPC(8): A61B5/1455
CPCA61B5/14553A61B5/72
Inventor 谢传建
Owner 杭州传一科技有限公司
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