The invention discloses a membrane separation-perfusion coupled blood purification apparatus. The membrane separation-perfusion coupled blood purification apparatus comprises a blood inlet end, a blood outlet end, a pre-flushing liquid outlet end, a pre-flushing liquid inlet end, a plasma separation unit shell, a plasma separation membrane assembly, an inlet and outlet filtering device, a plasma perfusion unit shell, plasma perfusion adsorption resin, a primary filtering device, a secondary filtering device and an upper end cover. The core of the plasma separation unit is a plasma separation membrane, and the core of the plasma perfusion unit is plasma perfusion adsorption resin. The apparatus integrates the functions of plasma separation and plasma perfusion; after plasma separation, plasma perfusion adsorption is carried out to remove target toxins, so operation process is simplified while the safety and effectiveness of blood purification are improved, the risks of blood loss and bacterial infection caused by operation are prevented, and the treatment cost is greatly reduced; and the two functions do not need to be connected through an extracorporeal circulation pipeline, so anextracorporeal circulation blood volume is reduced, and the risks of complications such as hypotension are reduced.