A kind of regeneration method of alumina column

An alumina column and alumina technology, applied in chemical instruments and methods, separation methods, filter regeneration, etc., can solve problems such as environmental pollution, lack of alumina column regeneration methods, cost increase, etc., to restore chromatography ability, Recovery of chromatographic ability and good purification effect

Active Publication Date: 2022-07-08
SICHUAN YUXIN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Alumina has a strong adsorption capacity. In plant extraction technology, alumina columns are commonly used for chromatography to remove impurities and pigments. However, commonly used alumina columns are replaced with new ones after one use. Old alumina columns are difficult to use in other places. The existing technology also lacks a regeneration method for the alumina column, which is often discarded directly or sent to a specialized resource recovery company, which will cause problems of environmental pollution or greatly increased costs

Method used

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  • A kind of regeneration method of alumina column
  • A kind of regeneration method of alumina column
  • A kind of regeneration method of alumina column

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Step 1. Add sodium hypochlorite solution with a mass fraction of 40% to the waste alumina column, the sodium hypochlorite solution flows through the alumina column at a flow rate of 150 L / h, and drips dry the alumina column. Wherein, the consumption of the sodium hypochlorite solution is 5 times the weight of the alumina.

[0027] Step 2, the purified water is passed through the drip-dried alumina column obtained in step 1, until the pH value of the outflowing liquid is 7, the alumina column is dripped dry, the flow rate is 100L / h, and the consumption of purified water is 100% of the alumina weight. 5 times.

[0028] Step 3, passing 97% ethanol by mass through the drip-dried alumina column obtained in step 2, until the ethanol concentration of the inflow and outflow is the same, drip-dry the alumina column to obtain a regenerated alumina column, wherein the flow rate is 100L / h, the amount of ethanol used is 5 times the weight of alumina.

Embodiment 2-10

[0030] The process of purification and recovery of the waste alumina column in Examples 2-10 is the same as that in Example 1, except that it is different from the concentration of sodium hypochlorite and the flow rate of sodium hypochlorite flowing through the alumina column.

experiment example

[0032] Chromatographic Capability Test of Regenerated Alumina Column and New Alumina Column

[0033] At present, the technical method for extracting puerarin from pueraria is generally to first clean the puerarin, dry it, then pulverize it into puerarin powder, and then obtain the crude puerarin through ultrasonic-assisted extraction, water extraction or alcohol extraction. Usually, the process of ultrasonic-assisted extraction is: pueraria root powder → ultrasonic extraction → filtration → concentration under reduced pressure → column passing → washing → alcohol washing → concentration under reduced pressure → vacuum drying → crude puerarin. Usually the process of water extraction method is: Pueraria lobata → water extraction → filtration to obtain filtrate and filter residue → sodium hydroxide solution to extract the residue → filtration to obtain filtrate → two filtrates combined → reduced pressure concentration → pH value adjustment → centrifugal separation → The filtrate ...

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Abstract

The invention provides a method for regenerating an alumina column, which includes the following steps: Step 1. Add a sodium hypochlorite solution with a mass fraction of 20% to 60% into the alumina column, and the sodium hypochlorite solution is 100L / h to 160L / h flow through the alumina column and drip dry the alumina column. Wherein, the amount of the sodium hypochlorite solution is not less than 4 times the weight of the alumina. Step 2, flowing purified water through the drip-dried alumina column obtained in step 1, until the pH value of the outflowing liquid is 7, and drip-dry the alumina column. Step 3: Flow ethanol with a mass fraction of not less than 90% through the drip-dried alumina column obtained in step 2 until the concentration of the ethanol flowing in and out is the same, and drip-dry the alumina column to obtain a regenerated alumina column. The method can effectively restore the chromatographic capacity of the alumina column, so that the alumina column can be recycled, the process is simple, the purification effect is good, and the industrial application can be easily realized.

Description

technical field [0001] The invention relates to the technical field of renewable resources, in particular to a method for regenerating an alumina column. Background technique [0002] Chromatography is a technique established by taking advantage of the differences in physical and chemical properties of different substances. All chromatography systems consist of two phases: a stationary phase and a mobile phase. When the mixture to be separated passes through the stationary phase with the mobile phase, due to the differences in the physical and chemical properties of each component, the ability to interact with the two phases (adsorption, dissolution, binding, etc.) is different, and the distribution (content ratio) in the two phases is different. ) are different, and as the mobile phase moves forward, the components are continuously redistributed between the two phases. The effluent is collected in parts, and each single component contained in the sample can be obtained, s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/34B01J20/08B01D15/20
CPCB01J20/3475B01J20/08B01D15/203Y02P10/20
Inventor 冷莉
Owner SICHUAN YUXIN PHARM CO LTD
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