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Regeneration method of alumina column

An alumina column and alumina technology, applied in chemical instruments and methods, separation methods, filter regeneration, etc., can solve problems such as cost increase, environmental pollution, lack of alumina column regeneration methods, etc., and achieve chromatographic capacity recovery, Recovery of chromatography ability and good purification effect

Active Publication Date: 2020-04-28
SICHUAN YUXIN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Alumina has a strong adsorption capacity. In plant extraction technology, alumina columns are commonly used for chromatography to remove impurities and pigments. However, commonly used alumina columns are replaced with new ones after one use. Old alumina columns are difficult to use in other places. The existing technology also lacks a regeneration method for the alumina column, which is often discarded directly or sent to a specialized resource recovery company, which will cause problems of environmental pollution or greatly increased costs

Method used

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  • Regeneration method of alumina column
  • Regeneration method of alumina column
  • Regeneration method of alumina column

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Step 1. Add a sodium hypochlorite solution with a mass fraction of 40% to the waste alumina column. The sodium hypochlorite solution flows through the alumina column at a flow rate of 150 L / h, and the alumina column is dripped dry. Wherein, the consumption of described sodium hypochlorite solution is 5 times of described aluminum oxide weight.

[0027] Step 2, flow the purified water through the dried alumina column obtained in step 1 until the pH value of the outflowing liquid is 7, drip dry the alumina column, the flow rate is 100L / h, and the consumption of purified water is 1% of the weight of alumina 5 times.

[0028] Step 3. Flow the ethanol with a mass fraction of 97% through the dried alumina column obtained in step 2 until the concentration of ethanol flowing in and out is the same, and drip dry the alumina column to obtain a regenerated alumina column, wherein the flow rate is 100 L / h, the amount of ethanol is 5 times the weight of alumina.

Embodiment 2-10

[0030] The process of purifying and recovering the waste alumina column in Examples 2-10 is the same as that of Example 1, except that the concentration of sodium hypochlorite and the flow rate of sodium hypochlorite flowing through the alumina column are different.

experiment example

[0032] Chromatographic capacity testing of regenerated alumina columns and new alumina columns

[0033] At present, the process for extracting puerarin from puerarin is generally to first wash pueraria, dry it, and then crush it into pueraria powder, and then obtain crude puerarin through ultrasonic-assisted extraction, water extraction or alcohol extraction. Usually, the process of ultrasonic-assisted extraction method is: kudzu root powder→ultrasonic extraction→filtration→decompression concentration→column passage→water washing→alcohol washing→decompression concentration→vacuum drying→crude puerarin. Usually the process of water extraction method is: Pueraria root powder→water extraction→filtering to obtain filtrate and filter residue→sodium hydroxide solution to extract residue→filtering to obtain filtrate→combining two filtrates→concentrating under reduced pressure→adjusting pH value→centrifugal separation→ Put the filtrate on a silica gel column → wash with water → ethano...

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Abstract

The invention provides a regeneration method of an alumina column, which comprises the following steps: 1, adding a sodium hypochlorite solution with a mass fraction of 20-60% to an alumina column, allowing the sodium hypochlorite solution to flow through the alumina column at a flow rate of 100-160 L / h, and drying the alumina column in a dripping manner; wherein the dosage of the sodium hypochlorite solution is not less than 4 times of the weight of the aluminum oxide; and 2, enabling purified water to flow through the dripped alumina column obtained in the step 1 until the pH value of the effluent liquid is 7, and dripping the alumina column; and step 3, enabling ethanol with the mass fraction of not less than 90% to flow through the dripped alumina column obtained in the step 2 until the concentrations of the ethanol flowing in and out are the same, and dripping the alumina column to obtain the regenerated alumina column. The method can effectively recover the chromatography capacity of the aluminum oxide column, so that the aluminum oxide column can be recycled, the process is simple, the purification effect is good, and industrial application is easy to realize.

Description

technical field [0001] The invention relates to the technical field of renewable resources, in particular to a method for regenerating alumina columns. Background technique [0002] Chromatography is a technique established by utilizing the differences in the physical and chemical properties of different substances. All chromatography systems consist of two phases: one is the stationary phase and the other is the mobile phase. When the mixture to be separated passes through the stationary phase with the mobile phase, due to the differences in the physical and chemical properties of each component, the ability to interact with the two phases (adsorption, dissolution, binding, etc.) is different, and the distribution (content ratio) in the two phases is different. ) are different, and as the mobile phase moves forward, each component is continuously redistributed in the two phases. By collecting the effluent in sections, each single component contained in the sample can be o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/34B01J20/08B01D15/20
CPCB01J20/3475B01J20/08B01D15/203Y02P10/20
Inventor 冷莉
Owner SICHUAN YUXIN PHARM CO LTD
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