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A superlubricious catheter material

A super-lubricating, catheter-based technology, applied in the field of medical materials, can solve problems such as easy blockage of blood vessel thrombosis, cardiovascular and cerebrovascular diseases, foreign body sensation in patients, etc., achieve excellent antibacterial performance and self-healing, high puncture success rate, and reduce foreign body sensation Effect

Active Publication Date: 2022-02-11
SUZHOU LINHWA MEDICAL DEVICES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the medical catheters commonly used in the prior art generally have the following problems: ① Poor lubricity, easy to block blood vessels, cause complications such as thrombosis, when entering the body or indwelling the body, it will also cause damage to the catheter when moving in the human body lumen. ②It is too soft or too hard to enter the blood vessel smoothly or cause foreign body sensation in the patient; ③It is easy to bend in the blood and cannot be restored, which will block the blood vessel and induce a heart attack. Cerebrovascular disease

Method used

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  • A superlubricious catheter material
  • A superlubricious catheter material
  • A superlubricious catheter material

Examples

Experimental program
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Effect test

preparation example Construction

[0080] In a preferred embodiment, the preparation method of the polyethylene glycol modified chitosan comprises the following steps:

[0081] Step a: Stir and mix 5-6 parts of chitosan, 1-2 parts of acetic acid, and 30-40 parts of distilled water in parts by weight to obtain a mixed solution;

[0082] Step b: In parts by weight, add 2 to 3 parts of polyethylene glycol into 30 to 40 parts of tetrahydrofuran under stirring conditions, and after stirring and mixing evenly, add 0.5 to 1 part of terephthalic acid and 0.1 to 0.3 parts of paraphthalic acid After dimethylaminopyridine, continue to add 1 to 2 parts of methyltetraylbicyclohexylamine, mix evenly, filter, and dry the filtrate to obtain a powder material;

[0083] Step c: adding 20-30 parts of the powder material obtained in step b to 9-16 parts of the mixed solution obtained in step a in parts by weight to obtain polyethylene glycol-modified chitosan.

[0084] In a more preferred embodiment, the preparation method of des...

Embodiment 1

[0109] Embodiment 1 of the present invention provides a super-lubricating catheter material, including the following raw materials in parts by weight: 22 parts of isocyanate, 45 parts of polyol, 18 parts of cross-linking agent, 10 parts of chain extender, and 12 parts of antibacterial agent.

[0110] Described isocyanate is the mixture of trimethyl hexamethylene diisocyanate and 1,4-cyclohexane dimethyl diisocyanate; Described trimethyl hexamethylene diisocyanate and 1,4-cyclohexane dimethyl diisocyanate The molar ratio of base diisocyanate is 3:7. The polyol is a mixture of polyethylene glycol and polyethylene adipate; the weight ratio of the polyethylene glycol and polyethylene adipate is 2:1; the Polyethylene glycol is the polyethylene glycol (PEG-2000) that relative molecular weight is 2000; Described polyethylene adipate is the polyethylene adipate that relative molecular weight is 2000 (PDA-2000). The cross-linking agent is 1,4-butanediol; the chain extender is hydroqu...

Embodiment 2

[0121] Embodiment 2 of the present invention provides a super-lubricating catheter material, including the following raw materials in parts by weight: 15 parts of isocyanate, 40 parts of polyol, 14 parts of cross-linking agent, 5 parts of chain extender, and 8 parts of antibacterial agent.

[0122] Described isocyanate is the mixture of trimethyl hexamethylene diisocyanate and 1,4-cyclohexane dimethyl diisocyanate; Described trimethyl hexamethylene diisocyanate and 1,4-cyclohexane dimethyl diisocyanate The molar ratio of base diisocyanate is 3:7. The polyol is a mixture of polyethylene glycol and polyethylene adipate; the weight ratio of the polyethylene glycol and polyethylene adipate is 2:1; the Polyethylene glycol is the polyethylene glycol (PEG-2000) that relative molecular weight is 2000; Described polyethylene adipate is the polyethylene adipate that relative molecular weight is 2000 (PDA-2000). The cross-linking agent is 1,4-butanediol; the chain extender is hydroquin...

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Abstract

The invention discloses a super-lubricating catheter material, which comprises the following raw materials in parts by weight: 15-25 parts of isocyanate, 40-50 parts of polyol, 14-22 parts of cross-chain agent, 5-15 parts of chain extender, and 8 parts of antibacterial agent ~16 parts; the polyol is a mixture of polyether polyol and polyester polyol. Experimental test results show that the ultra-lubricating catheter material prepared by the present invention has suitable hardness, can enter blood vessels smoothly, and will not cause discomfort to patients; the hardness will change at 25°C (room temperature) and 37°C (body temperature) , to ensure a high puncture success rate, and at the same time reduce the patient's foreign body sensation after entering the human body; at the same time, this product also shows super lubricity. In addition, the superlubricating catheter material prepared by the present invention is non-toxic and safe, is not easy to turn yellow, does not block blood vessels, does not produce thrombus, and has excellent antibacterial properties and self-healing properties, and has good practical application prospects.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a superlubricating catheter material. Background technique [0002] With the continuous improvement of medical level and the increasing frequency of use of medical consumables by Chinese residents, the medical consumables industry in my country has developed rapidly, especially the application proportion of medical catheters has also increased year by year. Since most of the medical catheters are directly in contact with body fluids, blood, and blood vessels, in addition to requiring biocompatibility such as non-irritating, non-toxic to human tissues, and minimal rejection by the body, many proposals have been made for their physical and chemical properties. Require. [0003] At present, the medical catheters commonly used in the prior art generally have the following problems: ① Poor lubricity, easy to block blood vessels, cause complications such as thrombosis, when entering t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G18/75C08G18/73C08G18/72C08G18/66C08G18/64C08G18/48C08G18/42C08G18/32C08B37/08
CPCC08G18/751C08G18/73C08G18/722C08G18/6607C08G18/6484C08G18/4833C08G18/4238C08G18/3215C08G18/3206C08B37/003
Inventor 吴林元吴以照
Owner SUZHOU LINHWA MEDICAL DEVICES CO LTD