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Gliquidone rapid release tablet and preparation method thereof

A fast technology for gliquidone, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, pill delivery, etc., can solve the problems of inability to relieve the disease in time, slow onset of drug effect, etc., to achieve easy absorption and ease the disease , quick effect

Pending Publication Date: 2020-05-01
CHENGDU HENGRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the domestic marketed preparations are common dosage forms, which have a significant disadvantage, that is, the onset of drug effect is slow, and the disease cannot be relieved in time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A gliquidone immediate-release tablet comprising:

[0034] Gliquidone 30mg;

[0035] Croscarmellose sodium 30mg;

[0036] Microcrystalline cellulose 100mg;

[0037] Magnesium stearate 1mg;

[0038] Starch 5mg.

[0039] Wherein: the sedimentation volume of croscarmellose sodium is 20ml.

[0040] Preparation method: GLiquidone and cross-linked carmellose sodium are 1:1 by weight through a planetary grinder (Model-PMRetsch Haan) at a speed of 200 rpm for 4 times × 30 minutes, and collected until mixed Mix it with starch and magnesium stearate evenly in the machine, and directly press 151mg / tablet into tablets, and control the hardness to 60N~100N.

Embodiment 2

[0042] A gliquidone immediate-release tablet comprising:

[0043] Gliquidone 45mg;

[0044] Croscarmellose sodium 45mg;

[0045] Microcrystalline cellulose 100mg;

[0046] Magnesium stearate 2mg;

[0047] Starch 10mg.

[0048] Wherein: the sedimentation volume of croscarmellose sodium is 25ml.

[0049] Preparation method: GLiquidone and cross-linked carmellose sodium are 1:1 by weight through a planetary grinder (Model-PMRetsch Haan) at a speed of 200 rpm for 4 times × 30 minutes, and collected until mixed Mix it with starch and magnesium stearate evenly in the machine, and directly press 151mg / tablet into tablets, and control the hardness to 60N~100N.

Embodiment 3

[0051] A gliquidone immediate-release tablet comprising:

[0052] Gliquidone 15mg;

[0053] Croscarmellose sodium 15 mg;

[0054] Microcrystalline cellulose 100mg;

[0055] Magnesium stearate 1mg;

[0056] Starch 5mg.

[0057] Wherein: the sedimentation volume of croscarmellose sodium is 17ml.

[0058] Preparation method: GLiquidone and cross-linked carmellose sodium are 1:1 by weight through a planetary grinder (Model-PMRetsch Haan) at a speed of 200 rpm for 4 times × 30 minutes, and collected until mixed Mix it with starch and magnesium stearate evenly in the machine, and directly press 151mg / tablet into tablets, and control the hardness to 60N~100N.

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PUM

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Abstract

The invention relates to a gliquidone rapid release tablet and a preparation method thereof. The tablet comprises 15 mg-180 mg of gliquidone, 10 mg-50 mg of cross-linked sodium carboxymethyl cellulose, 20 mg-150 mg of microcrystalline cellulose, and 1 mg-2 mg of magnesium stearate. The gliquidone and the cross-linked sodium carboxymethyl cellulose are passed through a planetary grinder (Model-PM Retsch Haan) at the ratio of 1: 1 by weight to conduct circular grinding at 200 rpm in 4 x 30 minutes. The above mixture is collected into the mixer and is mixed with starch and magnesium stearate evenly. The medicine is pressed directly at 151 mg per tablet, and the hardness is controlled within 60 N-100 N. In the present invention, glitaquinone is made into a rapid release tablet, thereby makingthe glitaquinone more easily to be absorbed by the human body, so that the tablet has a faster effect, and is suitable for quickly alleviating the disease.

Description

technical field [0001] The invention relates to a preparation method of a pharmaceutical preparation in the field of chemical pharmacy, in particular to a gliquidone quick-release tablet and a preparation method thereof. Background technique [0002] Gliquidone is a second-generation oral sulfonylurea hypoglycemic drug. It is a highly active pro-islet β-cell agent. It binds to specific receptors on the islet β-cell membrane and can induce the production of an appropriate amount of insulin to reduce blood sugar concentration. Its greatest advantage is that it can still be used in diabetic patients with kidney disease and mild abnormalities in renal function. [0003] The original research of Gliquidone Tablets is produced by Astellas Pharma GmbH / Glenwood GmbH Pharmazeutische Erzeugnisse, the English name is Gliquidone Tablets / Glurenorm, the listing size is 30 mg, the listing country is Germany, and the origin is Greece; the domestic listing dosage forms are tablets and capsul...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K31/64A61P3/10
CPCA61K9/2054A61K9/2095A61K31/64A61P3/10
Inventor 肖波
Owner CHENGDU HENGRUI PHARMA
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