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Chitosan catheter and its 3D printing device and printing method

A technology of 3D printing and printing device, applied in the field of 3D printing, can solve the problems of complex shape and structure of the catheter, difficult to meet individual needs, etc., and achieve the effects of excellent mechanical properties, increased convenience, and good biocompatibility

Active Publication Date: 2022-04-15
FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these methods provide some solutions, it is difficult to meet individual needs
The tissues and organs of the human body vary greatly between different individuals, and the shape and structure of the catheter are complex

Method used

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  • Chitosan catheter and its 3D printing device and printing method
  • Chitosan catheter and its 3D printing device and printing method
  • Chitosan catheter and its 3D printing device and printing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] [Preparation of Chitosan Slurry]

[0054] Select different acids and acid solutions with different mass concentrations to prepare chitosan slurry, as shown in Table 1 below.

[0055] The performance of the chitosan slurry prepared by the proportioning of table 1 is tested:

[0056] Tensile strength is tested according to GB / T1040-2006;

[0057] Cytotoxicity was tested according to ISO 10993-5 2016, and the cells used for the test were mouse fibroblasts (L-929, provided by the Cell Bank of the Chinese Academy of Sciences). Cell viability >70% indicates no potential cytotoxicity.

[0058] The preparation of table 1 chitosan slurry

[0059]

[0060]

Embodiment 2

[0061] It can be seen from Table 1 that the chitosan slurry containing glycolic acid (the mass concentration of glycolic acid is 30wt.%, the mass ratio of chitosan and acid solution is 1:4) has no potential cytotoxicity. This was used as a printing material for the following Examples 2-4. Example 2 A printing device and printing method combining an extrusion 3D printing module and a rotating module

[0062] Such as figure 1 In the printing device shown, the extruded 3D printing module was combined with the rotating module to prepare a chitosan catheter with a simple structure. The extrusion 3D printing module includes a gas inlet 1-1, a piston 1-2, a barrel 1-3 and a needle 1-5, and the barrel 1-3 contains chitosan slurry 1-4. The rotary module includes a stepper motor 1-6 and a rotary shaft 1-7 driven by the stepper motor 1-6, the rotary shaft 1-7 is used to support the chitosan slurry deposited thereon, and the stepper motor 1-6 places 1-8 on a 3D printing platform. Prin...

Embodiment 3

[0089] Example 3 Printing device and printing method combining extrusion 3D printing module and fused deposition module

[0090] like image 3 The extrusion 3D printing module shown is combined with the fused deposition module for the fabrication of chitosan catheters with complex structures.

[0091] The structure of extrusion 3D printing module is identical with embodiment 2, and fused deposition module comprises PVA coil 3-5, the PVA thread 3-4 that is wound on the PVA coil 3-5, feeder 3-3, heater 3-2 and nozzle 3-1. Printing process:

[0092] Under program control, the feeder 3-3 passes the PVA wire 3-4 in the PVA coil 3-5 to the heater 3-2. The PVA thread is melted and extruded through the nozzle 3-1 under the pressure provided by the feeder 3-3.

[0093] Under the action of the gas pressure fed into the gas inlet 1-1, the pressure is transmitted to the chitosan slurry through the piston 1-2, and the slurry is extruded from the needle 1-5.

[0094] Both the extrusion...

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Abstract

The invention discloses a chitosan catheter, a 3D printing device and a printing method thereof. Chitosan slurry includes: acid solution and chitosan dissolved in acid solution, acid solution is selected from at least one of formic acid solution, acetic acid solution, lactic acid solution and glycolic acid solution, the mass ratio of chitosan to acid solution is 1:(2‑10). The catheter is 3D printed from a chitosan slurry and optionally with or without a support material. The catheter printing device includes at least one of a rotation module, a fusion deposition module and a freeze-drying module, which are optionally used in combination with an extrusion 3D printing molding module. The device and printing method of the present invention can select a 3D printing method according to specific requirements to complete the preparation of a personalized catheter with a complex structure.

Description

technical field [0001] The invention relates to the field of 3D printing, in particular to a chitosan catheter, a 3D printing device and a 3D printing method thereof. Background technique [0002] The ducts of the body's soft tissues, such as the trachea, blood vessels, and pancreatic duct, are important in transporting secretory, nutritional, and metabolic waste. If there are lesions in these areas, some biomaterials are needed to repair them. Synthetic polymers such as polysiloxane, polyurethane (PU), polyhydroxyalkanoate (PHA), and polytetrafluoroethylene (PTFE) have been widely used to repair these tissues. Although these biomaterials have sufficient mechanical properties, their biocompatibility and degradability limit their further applications. Soft tissues that do not match the mechanical properties (such as Young's modulus) of degradable synthetic polymers such as polylactic acid (PLA), polycaprolactone (PCL), and polylactic-co-glycolic acid (PLGA) May cause injur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B29C64/118B29C64/20B29C64/245B29C64/30B29C64/393B33Y30/00B33Y50/02A61L27/20A61L27/50
CPCB29C64/118B29C64/20B29C64/245B29C64/30B29C64/393B33Y30/00B33Y50/02A61L27/20A61L27/50A61L2430/32A61L2430/34C08L5/08
Inventor 林锦新赵超前黄婷婷卢衍锦许泽亚
Owner FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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