Method for evaluating bone elasticity moduli by using photoacoustic time-domain signals

Abstract

The invention discloses a method for evaluating bone elasticity moduli by using photoacoustic time-domain signals. The method comprises the following steps of: firstly, regulating parameters of different bone trabecular materials to obtain cancellous bone models at different bone elasticity moduli; then simulating the cancellous bone models at different bone elasticity moduli to obtain corresponding photoacoustic time-domain signals; and performing preprocessing, including noise reduction and signal correction, on the photoacoustic time-domain signals; then quantizing the corrected photoacoustic time-domain signals to obtain the relationship between quantized parameters and the bone elasticity moduli; and finally, performing photoacoustic effect excitation on the cancellous bone to be detected to obtain the corresponding photoacoustic time-domain signals; and performing calculation according to the relationship between the quantized parameters and the bone elasticity moduli to obtain the bone elasticity modulus of the cancellous bone to be detected. The method has the advantages of no invasion, no radiation, low detection cost and operation convenience.

Description

technical field [0001] The invention relates to the technical field of bone evaluation, in particular to a method for evaluating bone elastic modulus by using photoacoustic time-domain signals. Background technique [0002] Osteoporotic fractures have high morbidity and mortality, and bring huge economic burdens to families and society. Osteoporosis has become an important health problem in the world, and has attracted extensive attention and research. Currently, the commonly used bone quality assessment methods in clinical practice are mainly based on X-ray and quantitative ultrasound. The existing "gold standard" for diagnosis is Dual X-ray absorptiometry (DXA), which can provide certain BMD information, but this information can only characterize part of the changes in bone strength and cannot characterize bone microstructure , bone elasticity, etc. are also important factors that determine the probability of fractures; some other 3D imaging methods can characterize bone ...

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Problems solved by technology

[0004] In the existing research, the application of photoacoustic technology is concentrated on photoacoustic imaging, most of which use the intensity information of photoacoustic signal as the imaging parameter, only considering the sensitivity of signal intensity to the difference of light absorption coefficient of various parts of biological tissue, and There is still little research on the relationship between signal intensity and other physical parameters of biological tissues, and the obtained images only reflect the distribution of light absorption coefficients in various parts of biological tissues, and photoacoustic imaging is widely used for the diagnosis of soft tissue diseases In the research, such as breast cancer, prostate cancer, skin cancer and other tumor diseases, as well as vascular diseases, there is a lack of research on hard tissue diseases such as osteoporosis

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