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Taxus chinensis (Pilg.) Rehd. var. mairei (Lemee et Levl.) Cheng et L. K. Fu (T. speciosa Florin) formula granules, and preparation method and quality control method thereof

A southern yew and formula granule technology, applied in the field of traditional Chinese medicine preparations, can solve the problems of inability to pass the appearance, long decocting time, microscopic identification specificity, etc., and achieves to make up for the lack of appearance and microscopic features, simple process, The effect of reducing adverse effects

Inactive Publication Date: 2020-05-12
HUBEI XIANGRUIFENG ECOLOGICAL FRUIT IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing traditional Chinese medicine formula granules mainly adopt the static decoction process. Although this method is simple, it has problems such as high temperature and long decoction time. Isothermal instability, long-term high-temperature decoction will lead to low extraction rate of active ingredients, large loss, and the content will be lower than the technical requirements of the standard decoction, which will affect the efficacy of the drug
Compared with traditional Chinese medicine decoction pieces, the properties of traditional Chinese medicine formula granules have changed, and specific identification cannot be carried out by means of appearance and microscopic identification. At present, there are no relevant reports on the quality control methods of southern yew formula granules

Method used

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  • Taxus chinensis (Pilg.) Rehd. var. mairei (Lemee et Levl.) Cheng et L. K. Fu (T. speciosa Florin) formula granules, and preparation method and quality control method thereof
  • Taxus chinensis (Pilg.) Rehd. var. mairei (Lemee et Levl.) Cheng et L. K. Fu (T. speciosa Florin) formula granules, and preparation method and quality control method thereof
  • Taxus chinensis (Pilg.) Rehd. var. mairei (Lemee et Levl.) Cheng et L. K. Fu (T. speciosa Florin) formula granules, and preparation method and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Put the decoction bag containing the southern yew decoction pieces (the southern yew medicinal materials are first removed and selected, cut into 0.5-1.5cm segmental decoction pieces and filled into the decoction bag) into the heating and stirring tank, add 10 times the amount of water, soaked for 0.5h, then heated to 60°C, stirred and extracted for 2.5h at a speed of 120rpm / min, filtered, collected the extract, added water to the medicinal residue to repeat the extraction once, and combined the two extracts.

[0044] 2. After the extract is filtered by a medicine filter, it is concentrated under reduced pressure at 60°C to a clear paste with a relative crude drug concentration of 0.80-1.00g / mL.

[0045] 3. The clear paste is dried by vacuum microwave, the oven temperature is 65°C, the vacuum degree is -0.08Mpa, the microwave power is 2-3KW, and the paste is dried to 4.5% ± 0.5% moisture content to obtain a dry paste.

[0046] 4. The dry paste is pulverized and sieve...

Embodiment 2

[0048] This embodiment is all the same as embodiment 1 except that the temperature adopted during the stirring extraction in step 1 is changed to 50°C.

Embodiment 3

[0050] This embodiment is all the same as embodiment 1 except that the temperature adopted in step 1 is changed to 70° C. during stirring and extraction.

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Abstract

The invention discloses a preparation method for taxus chinensis (Pilg.) Rehd. var. mairei (Lemee et Levl.) Cheng et L. K. Fu (T. speciosa Florin) formula granules. The preparation method comprises the following steps of: after water is added into taxus chinensis (Pilg.) Rehd. var. mairei (Lemee et Levl.) Cheng et L. K. Fu (T. speciosa Florin) for dipping, heating to 50-70 DEG C, carrying out stirring and extraction for 1.5-5 h, collecting extracting solutions, adding water into residual medicine residues for repeated extraction, and combining the extracting solutions; after the obtained extracting solution is filtered, carrying out vacuum concentration to obtain a clear cream; drying the clear cream to obtain a dry cream; and after the dry cream is smashed and sieved, obtaining a dry cream powder, then, adding auxiliary materials, evenly mixing, and carrying out granulation. While 10-deacetylation Baccatin III and 7-xyloside-10-deacetylation taxol obtained by the preparation method have a high content transfer rate, a cream yield is relatively high, and 1g of the prepared taxus chinensis (Pilg.) Rehd. var. mairei (Lemee et Levl.) Cheng et L. K. Fu (T. speciosa Florin) granules isequivalent to 2.5g of taxus chinensis (Pilg.) Rehd. var. mairei (Lemee et Levl.) Cheng et L. K. Fu (T. speciosa Florin) decoction pieces. The invention also provides a control characteristic atlas ofthe taxus chinensis (Pilg.) Rehd. var. mairei (Lemee et Levl.) Cheng et L. K. Fu (T. speciosa Florin) granules, and a construction method for the control characteristic atlas, and is used for controlling the quality of the taxus chinensis (Pilg.) Rehd. var. mairei (Lemee et Levl.) Cheng et L. K. Fu (T. speciosa Florin) granules, specificity is good, and a repetitive rate is high and stable.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a southern yew formula granule and its preparation and quality control methods. Background technique [0002] Southern yew belongs to the genus Taxus in the family Taxaceae. It is an ancient relic tree species left over from Quaternary glaciers and has a history of 2.5 million years on the earth. The whole plant of Taxus chinensis is rich in taxane compounds, which is the main source of extraction of paclitaxel, a broad-spectrum anticancer drug. Southern yew is also a traditional Chinese medicine, which can reduce swelling and dissipate stagnation, promote menstrual flow and diuresis, and is used for accumulation of lumps, edema, dysuria, rheumatic arthralgia, etc. There is no related report about southern yew granules. [0003] Traditional Chinese medicine formula granules are prepared by extracting, concentrating, drying, and granulating trad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K36/13A61P7/10A61P29/00A61P35/00G01N30/06G01N30/74G01N30/86
CPCA61K9/1623A61K9/1652A61K36/13A61K2236/331A61K2236/39A61P7/10A61P29/00A61P35/00G01N30/06G01N30/74G01N30/8634
Inventor 李晓胡亮亮
Owner HUBEI XIANGRUIFENG ECOLOGICAL FRUIT IND CO LTD
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