Alpha-tricalcium phosphate biological ceramic material and preparation method thereof

A bioceramic material, tricalcium phosphate technology, applied in the intersection of material science and biomedicine, can solve the problems of long reaction time and low product yield, and achieve low equipment requirements, good biocompatibility, and simple operation methods. Effect

Active Publication Date: 2020-05-12
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in follow-up studies, it was found that the product yield of this method was low, the reaction time was long, and the obtained powder was off-white (presumably caused by residual carbon after burning β-cyclodextrin)

Method used

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  • Alpha-tricalcium phosphate biological ceramic material and preparation method thereof
  • Alpha-tricalcium phosphate biological ceramic material and preparation method thereof
  • Alpha-tricalcium phosphate biological ceramic material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0057] 1) Accurately weigh the analytically pure Ca(NO 3 ) 2 4H 2 O 23.615g and (NH 4 ) 2 HPO 4 8.204g, were dissolved in 100ml of distilled water to make a solution.

[0058] 2) At room temperature (25°C), accurately measure 20ml of analytically pure ammonia water with a graduated cylinder, add to (NH 4 ) 2 HPO 4 In the solution, make the pH around 10, under the condition of magnetic stirring, Ca(NO 3 ) 2 Quickly added to the solution (NH 4 ) 2 HPO 4 In the solution, seal the container and keep stirring, and the reaction is completed after 10 minutes.

[0059] 3) Suction filter the above solution, wash 3 times with absolute ethanol after the suction filtration, and then air-dry for 4-8 hours (room temperature 25°C); then grind the dried particles in an agate mortar and then calcinate, The calcination treatment conditions are as follows: the heating rate is 10°C / min, the calcination time is 3h, the calcination temperature is 600°C, and the furnace is cooled to ob...

Embodiment 2

[0062] 1) Accurately weigh the analytically pure Ca(NO 3 ) 2 4H 2 O 23.615g and (NH 4 ) 2 HPO 4 8.204g, were dissolved in 100ml of distilled water to make a solution.

[0063] 2) At room temperature (25°C), accurately measure 20ml of analytically pure ammonia water with a graduated cylinder, add to (NH 4 ) 2 HPO 4 In the solution, make the pH around 10, under the condition of magnetic stirring, Ca(NO 3 ) 2 Quickly added to the solution (NH 4 ) 2 HPO 4 In the solution, seal the container and keep stirring, and the reaction is completed after 10 minutes.

[0064] 3) Suction filter the above solution, wash 3 times with absolute ethanol after the suction filtration, and then air-dry for 4-8 hours; then grind the dried particles in an agate mortar and then calcinate, the calcination treatment conditions are: The heating rate is 10°C / min, the calcination time is 3h, the calcination temperature is 650°C, and the α-tricalcium phosphate powder is obtained by cooling with ...

Embodiment 3

[0067] 1) Accurately weigh the analytically pure Ca(NO 3 ) 2 4H 2 O 23.615g and (NH 4 ) 2 HPO 4 8.204g, were dissolved in 100ml of distilled water to make a solution.

[0068] 2) At room temperature (25°C), accurately measure 20ml of analytically pure ammonia water with a graduated cylinder, add to (NH 4 ) 2 HPO 4 In the solution, make the pH around 10, under the condition of magnetic stirring, Ca(NO 3 ) 2 Quickly added to the solution (NH 4 ) 2 HPO 4 In the solution, seal the container and keep stirring, and the reaction is completed after 10 minutes.

[0069] 3) Suction filter the above solution, wash 3 times with absolute ethanol after the suction filtration, and then air-dry for 4-8 hours; then grind the dried particles in an agate mortar and then calcinate, the calcination treatment conditions are: The heating rate is 10°C / min, the calcination time is 3h, the calcination temperature is 700°C, and the α-tricalcium phosphate powder is obtained by cooling with ...

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Abstract

The invention relates to an alpha-tricalcium phosphate biological ceramic material and a preparation method thereof, belonging to the crossing field of material science and biomedicine. Alpha-tricalcium phosphate can be massively and directly prepared at a low temperature without additives, and can meet the industrial or medicinal demands for alpha-calcium phosphate bone cement on a larger scale.The preparation method is simple, expensive equipment is not needed, and the prepared alpha-tricalcium phosphate has high purity and good performance, so the alpha-tricalcium phosphate has good industrial application prospects and practical application values.

Description

technical field [0001] The invention belongs to the intersecting field of material science and biomedicine, and particularly relates to an alpha-tricalcium phosphate and a preparation method thereof. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Calcium phosphate cement (CPC), because of its excellent biocompatibility, bioactivity and osteoconductivity, has been used as a bone filling material in the field of orthopedics for many years. Unlike acrylic bone cements based on polymethyl methacrylate (PMMA), calcium phosphate cement (CPC) has a very low exothermic hardening reaction that does not cause damage to bone and muscle tissue, and the end product of the hydration r...

Claims

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Application Information

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IPC IPC(8): C04B35/447C04B35/626A61L27/12A61L27/10A61L27/50
CPCA61L27/10A61L27/12A61L27/50A61L2430/02C04B35/447C04B35/626C04B2235/3208
Inventor 李爱民杨福帅任尚轩孙康宁毕见强孙晓宁
Owner SHANDONG UNIV
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