Preparation of grass-leaved sweet-flag rhizome essential oil soft capsules and gasified inhalation type administration method for grass-leaved sweet-flag rhizome essential oil soft capsules

A drug delivery method, the technology of Shichangpu, applied in the field of traditional Chinese medicine, can solve the problems that drugs are difficult to pass through the blood-brain barrier, have intestinal side effects, and low bioavailability, and achieve good absorption, large surface area, and permeability high effect

Inactive Publication Date: 2020-05-15
YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Most of the clinically used preparations of Shichangpu are traditional preparations such as compound decoctions, tablets, and pills. The dosage is large, and there are intestinal side effects. The drugs are difficult to pass through the blood-brain barrier and have low bioavailability. secondary development

Method used

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  • Preparation of grass-leaved sweet-flag rhizome essential oil soft capsules and gasified inhalation type administration method for grass-leaved sweet-flag rhizome essential oil soft capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Extraction of volatile oil of Shichangpu

[0030] Weigh 1.5 kg of Shichangpu medicinal material, add 8 times the amount of water to soak for 2 hours, extract the volatile oil according to the method B under the 2015 edition of "Chinese Pharmacopoeia" Volatile Oil Determination Method (General Rule 2204), use steam distillation to extract for 6 hours, and use anhydrous sulfuric acid to extract the volatile oil. After sodium dehydration, (25.5±1.5) mL of thick yellow oil was obtained, and the calculated volatile oil yield was (1.70±0.1)%. The prepared volatile oil was stored at -18°C.

[0031] 2. Preparation of Shichangpu volatile oil soft capsules

[0032] (1) To prepare 100g of inner material liquid, weigh 10g of Acorus volatile oil, 1g of cannabis wax, 0.1g of borneol, 0.1g of mint ice, and 88.8g of glycerin. Heating glycerin to 50°C, adding marijuana wax, borneol, and mint ice, stirring to dissolve, cooling to room temperature after dissolving, then adding volati...

Embodiment 2

[0039] 1, the extraction of Shichangpu volatile oil is with embodiment 1.

[0040] 2. Preparation of Shichangpu volatile oil soft capsules

[0041](1) Prepare 100g of internal material liquid, weigh 15g of volatile oil of Acorus calamus, 2g of cannabis wax, 1g of borneol, 0.5g of mint ice, and 81.5g of glycerin. Heating glycerin to 50°C, adding marijuana wax, borneol, and mint ice, stirring to dissolve, cooling to room temperature after dissolving, then adding volatile oil of calamus calamus and stirring evenly to obtain an inner material liquid.

[0042] All the other steps are the same as in Example 1.

Embodiment 3

[0044] 1, the extraction of Shichangpu volatile oil is with embodiment 1.

[0045] 2. Preparation of Shichangpu volatile oil soft capsules

[0046] (1) Prepare 100g of internal material liquid, weigh 20g of volatile oil of Acorus calamus, 5g of cannabis wax, 1.0g of borneol, 1.0g of mint ice, and 73g of glycerin. Heating glycerin to 50°C, adding marijuana wax, borneol, and mint ice, stirring to dissolve, cooling to room temperature after dissolving, then adding volatile oil of calamus calamus and stirring evenly to obtain an inner material liquid.

[0047] All the other steps are the same as in Example 1.

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Abstract

The invention provides preparation of grass-leaved sweet-flag rhizome essential oil soft capsules and a gasified inhalation type administration method for the grass-leaved sweet-flag rhizome essentialoil soft capsules and belongs to the technical field of traditional Chinese pharmacology. Grass-leaved sweet-flag rhizome essential oil has the effects of benefiting intelligence and invigorating brain and improving learning memory ability. According to the preparation of the grass-leaved sweet-flag rhizome essential oil soft capsules and the gasified inhalation type administration method for thegrass-leaved sweet-flag rhizome essential oil soft capsules, the grass-leaved sweet-flag rhizome essential oil is prepared into a dosage form of soft capsules, drug administration is carried out by using an electronic heater, content drugs of the soft capsules can be gasified through heating the temperature of the soft capsules to a certain temperature by the electronic heater, the gasified drugsare inhaled to a nasal cavity by a sufferer in a smoking-similar manner, the drugs can be directly absorbed into brain tissue through olfactory nerve passages and olfactory mucosa epithelium passagesso as to exert the effects of benefiting intelligence and invigorating brain and improving learning memory ability, and thus, the grass-leaved sweet-flag rhizome essential oil soft capsules can be applied to prevention and adjuvant therapy of Alzheimer's disease (senile dementia).

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese pharmacy, and in particular relates to the preparation of Shichangpu volatile oil soft capsule and its gasification and inhalation administration method. Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is a neurodegenerative disease with insidious onset and progressive development. Clinically, it is characterized by generalized dementia such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and personality and behavior changes. Clinically, memory dysfunction and learning and cognitive decline are one of the first symptoms of AD patients. Drugs used to treat senile dementia often have side effects such as nausea, dizziness, sweating, abdominal pain, and blurred vision, and are not suitable for normal people to take for a long time. Therefore, the development of effective, safe, and non-toxic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61K9/48A61K9/72A61P25/28A61K31/045
CPCA61K9/0043A61K9/4825A61K31/045A61K36/60A61K36/888A61P25/28A61K2300/00
Inventor 刘胜贵王钲霖马海悦付彬彬李智高孔令羽
Owner YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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