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Composition containing mahoniae caulis extract and cordycepin, preparation and application of composition and preparation

A kind of Gonggong wood alcohol and composition technology, applied in the field of medicine and health care, can solve the problem of lack of lipid-lowering and weight-loss drugs and health care products, and achieve the effects of inhibiting the formation of lipid droplets, obvious efficacy, and weight-loss effect

Active Publication Date: 2020-05-22
SHENZHEN SUNNY BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is a lack of lipid-lowering and weight-loss drugs and health products with Gongluomu and cordycepin as the main raw materials

Method used

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  • Composition containing mahoniae caulis extract and cordycepin, preparation and application of composition and preparation
  • Composition containing mahoniae caulis extract and cordycepin, preparation and application of composition and preparation
  • Composition containing mahoniae caulis extract and cordycepin, preparation and application of composition and preparation

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[0025] In the present invention, the mass ratio of the ethanol extract and cordycepin is preferably 1:1. In the present invention, the ethanol extract is preferably extracted with an aqueous ethanol solution with a volume fraction of 45% to 55%, more preferably obtained through extraction with an aqueous ethanol solution with a volume fraction of 50%. In the present invention, the preparation method of the alcoholic extract of the eucalyptus comprises the following steps: after mixing and soaking the eucalyptus and an aqueous ethanol solution, reflux extraction for 1-2 hours, collecting the extract, and drying to obtain the alcohol extract of the eucalyptus. In the present invention, the meritorious wood is preferably crushed before being mixed with the aqueous ethanol solution. The particle size of the meritorious wood after crushing is not particularly limited in the present invention, and conventional crushing is sufficient. In the present invention, the volume ratio of the...

Embodiment 1

[0034] The preparation method of Gongluo wood alcohol extract:

[0035] 1. Weigh 50g of gonglao wood, pulverize, sieve with 50 mesh, put it into a 500mL round bottom flask, add 10 times the volume of 50% (volume fraction) ethanol solution and soak at room temperature (25°C) for 2h.

[0036] 2. Place the round bottom flask in a heating mantle, heat at 100°C and reflux for 1.5h to collect the extract.

[0037] 3. Filter the extract with double layers of 200-mesh silk cloth, pour the filtrate into a rotary evaporator at 60°C, condense it into a paste by rotary evaporation, collect the concentrate, and store it in a refrigerator at 4°C.

[0038] 4. Pour the concentrated solution into a suitable container, carry out vacuum drying, 100°C, 1h, 80°C, 3h, the dry extract obtained is the alcohol extract of konjac, weighing 2.12g, and the extraction rate is 4.24%.

[0039] The source of cordycepin: commercially available. The lipid-lowering and weight-reducing composition comprises the...

Embodiment 2

[0041] The preparation method of Gongluo wood alcohol extract:

[0042] 1. Weigh the gonglao wood, crush it, sieve it with 50 mesh, put it into a 500mL round bottom flask, add 10 times the volume of 50% (volume fraction) ethanol solution and soak it at room temperature (25°C) for 2h.

[0043] 2. Place the round bottom flask in a heating mantle, heat at 100°C and reflux for 1.5h to collect the extract.

[0044]3. Filter the extract with a double layer of 200-mesh silk cloth, pour the filtrate into a rotary evaporator, condense it into a paste by rotary evaporation at 60°C, collect the concentrate, and store it in a refrigerator at 4°C.

[0045] 4. Pour the concentrated solution into a suitable container, carry out vacuum drying, 100°C, 1h, 80°C, 3h, to obtain a dry extract, and collect the dry extract as the alcohol extract of Gongluomu.

[0046] The source of cordycepin: commercially available.

[0047] The lipid-lowering and weight-reducing composition comprises the alcohol...

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Abstract

The invention provides a composition as well as preparation method and application thereof, and belongs to the technical fields of medicine and healthcare. The composition contains a mahoniae caulis extract and cordycepin in a mass ratio being 1: (0.5-1.5); and the composition can inhibit 3T3-L1 precursor adipocyte proliferation and has certain time and dose dependence. The composition can inhibitadipocyte differentiation and formation of lipid droplets in the differentiation process and has significant weight losing and lipid reducing effects.

Description

technical field [0001] The invention belongs to the technical field of medicine and health care, and in particular relates to a composition, a preparation and an application thereof comprising an alcohol extract of konjac wood and cordycepin. Background technique [0002] Obesity and dyslipidemia are important risk factors for cardiovascular and cerebrovascular diseases, and hyperlipidemia is one of the most direct and typical complications of obesity. With the improvement of people's living standards, the population of obesity and overweight is rising rapidly, and obesity has become one of the major factors leading to human death. At least 2.8 million adults worldwide die from obesity-related diseases every year. Hyperlipidemia is one of the most typical complications of obesity. Every year, 12 to 16 million people worldwide die from cardiovascular diseases caused by hyperlipidemia. Therefore, the research and development of lipid-lowering and weight-loss drugs and health ...

Claims

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Application Information

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IPC IPC(8): A61K36/29A61K31/7076A61P3/04
CPCA61K31/7076A61K36/29A61K2236/333A61P3/04A61K2300/00
Inventor 刘蕊唐旭东许剑怡王宏娟周艳丽杜文超
Owner SHENZHEN SUNNY BIO TECH CO LTD
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