Composition containing mahoniae caulis extract and cordycepin, preparation and application of composition and preparation

A kind of Gonggong wood alcohol and composition technology, applied in the field of medicine and health care, can solve the problem of lack of lipid-lowering and weight-loss drugs and health care products, and achieve the effects of inhibiting the formation of lipid droplets, obvious efficacy, and weight-loss effect

Active Publication Date: 2020-05-22
SHENZHEN SUNNY BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is a lack of lipid-lowering and weight-loss drugs

Method used

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  • Composition containing mahoniae caulis extract and cordycepin, preparation and application of composition and preparation
  • Composition containing mahoniae caulis extract and cordycepin, preparation and application of composition and preparation
  • Composition containing mahoniae caulis extract and cordycepin, preparation and application of composition and preparation

Examples

Experimental program
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Example Embodiment

[0025] In the present invention, the mass ratio of the wood alcohol extract and cordycepin is preferably 1:1. In the present invention, the alcohol extract of Magnolia sinensis is preferably obtained by extraction with an ethanol aqueous solution with a volume fraction of 45%-55%, and more preferably obtained by extraction with an ethanol aqueous solution with a volume fraction of 50%. In the present invention, the preparation method of the alcohol extract of the kungloah wood includes the following steps: after mixing and soaking the kung-lao wood alcoholic extract with the ethanol aqueous solution, reflux extraction for 1 to 2 hours, collecting the extract, and drying to obtain the kunglok wood alcohol extract. In the present invention, the koji tree is preferably pulverized before being mixed with the ethanol aqueous solution. The present invention does not specifically limit the particle size of the koji tree after pulverization, and conventional pulverization is sufficient....

Example Embodiment

[0033] Example 1

[0034] The preparation method of Kungfu wood alcohol extract:

[0035] 1. Weigh 50g of Gongluomu, crushed, sieved with 50 meshes, put into a 500mL round-bottomed flask, and add 10 times the volume of 50% (volume fraction) ethanol solution to soak at room temperature (25°C) for 2h.

[0036] 2. Place the round-bottomed flask in a heating mantle, heat at 100°C and reflux for 1.5h, and collect the extract.

[0037] 3. Filter the extract with a double layer of 200-mesh silk cloth, pour the filtrate into a rotary evaporator at 60°C, spin-evaporate and concentrate to a paste, collect the concentrated solution, and store it in a refrigerator at 4°C.

[0038] 4. Pour the concentrated solution into a suitable container and dry it in a vacuum at 100°C, 1h, 80°C, 3h, to obtain the dried extract as the Kungfu alcohol extract, weighing 2.12g, and the extraction rate is 4.24%.

[0039] Source of cordycepin: commercially available. The lipid-lowering and weight-loss composition inclu...

Example Embodiment

[0040] Example 2

[0041] The preparation method of Kungfu wood alcohol extract:

[0042] 1. Weigh the wormwood, pulverize, sieved with 50 mesh, put it into a 500mL round bottom flask, add 10 times the volume of 50% (volume fraction) ethanol solution to soak at room temperature (25°C) for 2 hours.

[0043] 2. Place the round-bottomed flask in a heating mantle, heat at 100°C and reflux for 1.5h, and collect the extract.

[0044] 3. Filter the extract with a double layer of 200-mesh silk cloth, pour the filtrate into a rotary evaporator, spin-evaporate at 60°C and concentrate to a paste, collect the concentrated solution, and store it in a refrigerator at 4°C.

[0045] 4. Pour the concentrated solution into a suitable container and dry it in a vacuum at 100°C, 1h, 80°C, 3h to obtain a dry extract, and collect the dry extract as the Kungfu wood alcohol extract.

[0046] Source of cordycepin: commercially available.

[0047] The lipid-lowering and weight-reducing composition includes kungfu w...

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Abstract

The invention provides a composition as well as preparation method and application thereof, and belongs to the technical fields of medicine and healthcare. The composition contains a mahoniae caulis extract and cordycepin in a mass ratio being 1: (0.5-1.5); and the composition can inhibit 3T3-L1 precursor adipocyte proliferation and has certain time and dose dependence. The composition can inhibitadipocyte differentiation and formation of lipid droplets in the differentiation process and has significant weight losing and lipid reducing effects.

Description

technical field [0001] The invention belongs to the technical field of medicine and health care, and in particular relates to a composition, a preparation and an application thereof comprising an alcohol extract of konjac wood and cordycepin. Background technique [0002] Obesity and dyslipidemia are important risk factors for cardiovascular and cerebrovascular diseases, and hyperlipidemia is one of the most direct and typical complications of obesity. With the improvement of people's living standards, the population of obesity and overweight is rising rapidly, and obesity has become one of the major factors leading to human death. At least 2.8 million adults worldwide die from obesity-related diseases every year. Hyperlipidemia is one of the most typical complications of obesity. Every year, 12 to 16 million people worldwide die from cardiovascular diseases caused by hyperlipidemia. Therefore, the research and development of lipid-lowering and weight-loss drugs and health ...

Claims

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Application Information

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IPC IPC(8): A61K36/29A61K31/7076A61P3/04
CPCA61K31/7076A61K36/29A61K2236/333A61P3/04A61K2300/00
Inventor 刘蕊唐旭东许剑怡王宏娟周艳丽杜文超
Owner SHENZHEN SUNNY BIO TECH CO LTD
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