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Injectable hydrogel, preparation method and application thereof, and joint lubricant

A technology for injecting water and gel, which is applied in medical formula, surgery, drug delivery, etc., to achieve the effect of reducing the number of administration, low cost, and prolonging the therapeutic effect

Active Publication Date: 2021-12-03
SAIKE SAISI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Carboxymethyl chitin stays in the human body longer than hyaluronic acid, but it still needs to be injected every 2 weeks

Method used

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  • Injectable hydrogel, preparation method and application thereof, and joint lubricant
  • Injectable hydrogel, preparation method and application thereof, and joint lubricant
  • Injectable hydrogel, preparation method and application thereof, and joint lubricant

Examples

Experimental program
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Effect test

preparation example Construction

[0053] In another aspect of the present invention, the present invention provides a method for preparing the aforementioned injectable hydrogel, the preparation method comprising:

[0054] The injectable hydrogel is obtained after mixing a macromolecular biological cross-linking agent, a small molecular cross-linking agent and carboxymethyl chitosan and reacting. Therefore, the operation is simple, convenient and easy to realize.

[0055] It should be noted that the above-mentioned macromolecular biological cross-linking agent, small molecular cross-linking agent and carboxymethyl chitosan are consistent with the previous description, and will not be repeated here.

[0056] In some embodiments of the present invention, the above-mentioned preparation method comprises:

[0057] Dissolving the macromolecular biological crosslinking agent and the small molecular crosslinking agent in the first solvent to obtain a first solution;

[0058] dissolving carboxymethyl chitosan in a s...

Embodiment 1-7、 comparative example 1

[0086] The injectable hydrogel is prepared as follows:

[0087] Dissolve 1.0 g of commercially available carboxymethyl chitosan CMCTS-1 in 20 ml of normal saline to make a solution with a concentration of 5%, and filter and sterilize for subsequent use; dissolve O-HA and GA in 20 ml of normal saline to make a solution, The molar ratio of aldehyde groups in O-HA and GA is 1:1, filter and sterilize for later use; mix the above two solutions (cross-linking ratio is 0.3:1), stir evenly, pour the beaker every 15s, and measure the different water setting The gelation time of the glue;

[0088] Wherein, the degree of oxidation of O-HA in Examples 1-7 is 5%, 10%, 20%, 40%, 60%, 80% and 90% respectively, and the degree of oxidation of O-HA in Comparative Example 1 is 0. The gelation time of the injectable hydrogel in 1-7 and Comparative Example 1 is shown in Table 1 below:

[0089] Table 1

[0090]

Embodiment 8-14

[0092] The injectable hydrogel is prepared as follows:

[0093] Dissolve 1.0g carboxymethyl chitosan CMCTS-1 in 20ml physiological saline to make a solution with a concentration of 5%, and filter and sterilize for subsequent use; O-HA (degree of oxidation is 40%) and GA are dissolved in 20ml physiological Salt water, made into a solution, filtered and sterilized for later use; mix the above two solutions (crosslinking ratio is 0.5:1), stir evenly, pour the beaker every 15s, and measure the gelation time of different hydrogels;

[0094] Wherein, the ratio of the moles of aldehyde groups in O-HA to the total moles of aldehyde groups in O-HA and GA in Examples 8-14 is shown in Table 2 below, and the ratio of the injectable hydrogel in Examples 8-14 The gelation time is shown in the following table 2:

[0095] Table 2

[0096]

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Abstract

The invention provides an injectable hydrogel, its preparation method, application and joint lubricant, and relates to the technical field of osteoarthritis treatment. The injectable hydrogel includes the following raw materials: macromolecular biological cross-linking agent, small molecular cross-linking agent Linking agent and carboxymethyl chitosan; The macromolecular biological crosslinking agent includes at least one of oxidized sodium hyaluronate, oxidized sodium alginate, oxidized sodium carboxymethyl cellulose, oxidized starch and oxidized dextran ; The small molecule crosslinking agent includes an aldehyde crosslinking agent with a molecular weight of 200 or less. The injectable hydrogel has a good effect on cartilage lubrication and protection in the treatment of osteoarthritis, and can play the role of prolonging the treatment effect and reducing the number of administrations.

Description

technical field [0001] The invention relates to the technical field of osteoarthritis treatment, in particular to an injectable hydrogel, its preparation method and application, and a joint lubricant. Background technique [0002] Osteoarthritis is a common chronic disease among middle-aged and elderly people. The clinical manifestations are joint pain, swelling, and stiffness. In severe cases, joint deformity and dysfunction occur, often accompanied by secondary synovitis. Its main pathological features are progressive degeneration and destruction of articular cartilage, progressive loss of cellular nutrients in cartilage tissue, secondary hyperosteogeny, and reduction of chondrocytes and formation of osteophytes in the middle and late stages. Its prevalence rate is higher in middle-aged and elderly people, the crowd over 60 years old can reach 50%, and the crowd of 75 years old can reach 80%. The disability rate of this disease can be as high as 53%. one of the major dise...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/14C08J3/24C08J3/075C08L5/08C08L5/04C08L1/28C08L5/02C08K5/07
CPCA61L31/041A61L31/145A61L2400/06C08J3/075C08J3/24C08J2305/08C08J2401/28C08J2405/02C08J2405/04C08J2405/08C08K5/07C08L5/08
Inventor 姜晓蕾彭显博陈文静王斯姝孔建薛会群
Owner SAIKE SAISI BIOTECH CO LTD
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