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Traditional Chinese medicine preparation for osteoporosis, osteonecrosis, bone generation and blood circulation promotion and preparation method thereof

A technology for traditional Chinese medicine preparations and osteoporosis, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, bone diseases, etc., and can solve problems such as unsatisfactory curative effect, high cost, and large side effects.

Inactive Publication Date: 2020-06-09
HUANBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, for osteonecrosis, conservative treatment is mainly used in the early stage, and artificial replacement is used in the late stage, which has the disadvantages of high cost, long course of treatment, large side effects, and unsatisfactory curative effect.

Method used

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  • Traditional Chinese medicine preparation for osteoporosis, osteonecrosis, bone generation and blood circulation promotion and preparation method thereof
  • Traditional Chinese medicine preparation for osteoporosis, osteonecrosis, bone generation and blood circulation promotion and preparation method thereof
  • Traditional Chinese medicine preparation for osteoporosis, osteonecrosis, bone generation and blood circulation promotion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] A traditional Chinese medicine tablet for osteoporosis, osteonecrosis and promoting bone and blood circulation, prepared from the following raw materials:

[0080] War bone 350kg, swollen joint wind 350kg, natural copper 65kg, salvia miltiorrhiza 250kg, corydalis 250kg, achyranthes bidentata 75kg, Eucommia 75kg.

[0081] Its preparation method is as follows:

[0082] (1) Crush the raw material into a powder with a particle size of 10 μm, put it into a high-pressure tank, pressurize at 22°C to make the pressure in the high-pressure tank reach 16 MPa and keep the pressure for 8 minutes, and then release the pressure of the high-pressure tank to within 0.1s Atmospheric pressure, collect the material in the high pressure tank;

[0083] (2) Add disodium hydrogen phosphate-citric acid buffer solution with a pH of 5.5 to the material in step (1), the solid-liquid weight / volume ratio is 1:15, and reflux extraction at 50°C for 3 times, each extraction time 3h, 2h, and 1.5h res...

Embodiment 2

[0089] A traditional Chinese medicine capsule for osteoporosis, osteonecrosis and promoting bone and blood circulation, prepared from the following raw materials:

[0090] War bone 370kg, swollen joint wind 375kg, natural copper 70kg, salvia miltiorrhiza 270kg, corydalis 260kg, achyranthes bidentata 90kg, Eucommia 88kg.

[0091] Its preparation method is as follows:

[0092] (1) Crush the raw material into a powder with a particle size of 20 μm, put it into a high-pressure tank, pressurize at 22.5°C to make the pressure in the high-pressure tank reach 16.5 MPa and keep the pressure for 7.5 minutes, and then release the high-pressure tank within 0.2s Press down to normal pressure to collect the material in the high pressure tank;

[0093] (2) Add disodium hydrogen phosphate-citric acid buffer solution with a pH of 5.7 to the material in step (1), the solid-liquid weight / volume ratio is 1:16, and reflux extraction at 54°C for 2 times, each extraction time 3h and 2.5h respectiv...

Embodiment 3

[0099] A traditional Chinese medicine syrup for osteoporosis, osteonecrosis and promoting bone and blood circulation, prepared from the following raw materials:

[0100] War bone 390kg, swollen joint wind 400kg, natural copper 75kg, salvia miltiorrhiza 295kg, corydalis 280kg, achyranthes bidentata 100kg, Eucommia 100kg.

[0101] Its preparation method is as follows:

[0102] (1) Crush the raw materials into powders with a particle size of 30 μm, put them into a high-pressure tank, pressurize at 23°C to make the pressure in the high-pressure tank reach 17 MPa and keep the pressure for 7 minutes, and then release the pressure in the high-pressure tank to within 0.3s Atmospheric pressure, collect the material in the high pressure tank;

[0103] (2) Add disodium hydrogen phosphate-citric acid buffer solution with a pH of 6.2 to the material in step (1), the solid-liquid weight / volume ratio is 1:18, and reflux extraction at 59°C for 3 times, each extraction time 2.5h, 2h, and 1.5...

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Abstract

The invention discloses a traditional Chinese medicine preparation for osteoporosis, osteonecrosis, bone generation and blood circulation promotion. The traditional Chinese medicine preparation is prepared from premna fulva Craib, sarcandra twigs and leaves, natural copper, red sage roots, corydalis tubers, twotoothed achyranthes roots and eucommia bark. The invention also provides a preparation method of the traditional Chinese medicine preparation. According to the principle of combining the traditional Chinese medicine theory and the western medicine theory, the traditional Chinese medicinepreparation provided by the invention is scientifically proportioned, and the traditional Chinese medicines are matched with each other to offset weakness, so that traditional Chinese medicine preparation has the effects of promoting blood circulation and removing blood stasis, dredging collaterals and setting bones, relieving swelling and pain, and strengthening tendons and bones, and has obvious effects on treating fracture, osteoporosis and osteonecrosis. Pharmacodynamic and toxicological tests show that the traditional Chinese medicine preparation has obvious effects, has no toxic or sideeffects, and overcomes the defects that western medicines can damage liver and kidney functions and the like after being taken for a long time. The traditional Chinese medicine preparation prepared by using a folk secret prescription of the Zhuang nationality can be prepared into various dosage forms, is convenient and safe to carry and take, and reduces or avoids danger, injury and pain caused by intravenous drip and intramuscular injection treatment. The traditional Chinese medicine preparation has advantages of short treatment course, quick response and wide application range, and has a wide application prospect.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine preparation for osteoporosis, osteonecrosis and bone-promoting blood circulation and a preparation method thereof. Background technique [0002] Due to external force or pathological factors, the bone or trabecular bone breaks apart and loses its integrity, which is called fracture. Fracture is a common and frequently-occurring disease. Clinically, there are many patients with this kind of disease, especially in the vast rural areas and mountainous areas, so the market potential is relatively large. [0003] The causes of fractures include direct violence, indirect violence, strong contraction of muscles, persistent strain, age and health status, skeletal lesions and so on. In the early stage of fracture, due to the injury of tendons and bone meridians, the blood stasis from the meridians persists, resulting in swelling at the fracture s...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61P19/10A61P19/08A61K33/26
CPCA61K33/26A61K36/185A61K36/21A61K36/46A61K36/537A61K36/66A61K36/85A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61P19/08A61P19/10A61K2300/00
Inventor 冯成林
Owner HUANBAO PHARMA