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A kind of extraction method of Panax notoginseng saponins

A technology of Panax notoginseng total saponins and an extraction method, applied in the field of extraction of Panax notoginseng total saponins, can solve the problems of complex process, difficult to guarantee yield and content, long time consumption, etc., and achieves high content, high yield and improved efficiency. Effect

Active Publication Date: 2021-10-22
GUANGDONG YILI LUODING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems existing in the existing extraction methods of Panax notoginseng saponins such as long time-consuming, complicated process, and difficult to guarantee the yield and content, a more efficient and environmentally friendly extraction method should be found, so as to obtain Panax notoginseng with higher yield and content. saponins

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A method for extracting Panax notoginseng saponins, comprising the following steps:

[0036] (1) Pretreatment: sorting, cleaning and drying the Radix Notoginseng and pulverizing it to a particle size of 10 mesh;

[0037] (2) Enzymolysis: add water, citric acid and malic acid to the crushed Panax notoginseng (the weight ratio of the three is 50:1:0.5, the total amount added is 1.5 times the weight of the crushed Panax notoginseng) at 30°C Soak for 1.2h under the conditions, and after drying, crush again to a particle size of 80 meshes, add 0.5% cellulase and pectinase (the weight ratio of the two is 2: 1) After fully stirring, carry out the first enzymolysis under the condition of 50°C water bath for 1.2h, then add cellulase and β-amylase (the weight ratio of the two is 2:1), after fully stirring, microwave heating is assisted to carry out the second enzymolysis, the microwave heating time is 4min, the power is 400W, and the enzymolysis material is obtained;

[0038] (...

Embodiment 2

[0041] A method for extracting Panax notoginseng saponins, comprising the following steps:

[0042] (1) Pretreatment: select, wash and dry the Radix Notoginseng and crush it to a particle size of 20 mesh;

[0043](2) Enzymolysis: add water, citric acid and malic acid to the pulverized Panax notoginseng (the weight ratio of the three is 60:1.2:0.8, the total amount added is 1.8 times the weight of the pulverized Panax notoginseng added) at 40°C Soak for 0.5h under the conditions, and after drying, crush again to a particle size of 100 meshes, add 0.9% cellulase and pectinase (the weight ratio of the two is 3: 1) After fully stirring, carry out the first enzymolysis under the condition of 60° C. water bath for 1 h, then add cellulase and β-amylase (the weight ratio of the two is 5:3), after fully stirring, microwave heating is assisted to carry out the second enzymolysis, the microwave heating time is 9min, the power is 300W, and the enzymolysis material is obtained;

[0044] ...

Embodiment 3

[0047] A method for extracting Panax notoginseng saponins, comprising the following steps:

[0048] (1) Pretreatment: select, wash and dry the Radix Notoginseng and crush it to a particle size of 16 mesh;

[0049] (2) Enzymolysis: add water, citric acid, and malic acid to the crushed Panax notoginseng (the weight ratio of the three is 55:1:0.6, and the total amount added is 1.6 times the weight of the crushed Panax notoginseng added) at 35°C Soak under the conditions for 0.8h, after drying, crush again to a particle size of 90 meshes, add 0.8% cellulase and pectinase (the weight ratio of the two is 2.8: 1) After fully stirring, carry out the first enzymolysis for 1.1 h under the condition of 55° C. water bath, and then add cellulase and β-amylase (the weight ratio of the two is 2:1), after fully stirring, microwave heating is assisted to carry out the second enzymolysis, the microwave heating time is 5min, the power is 350W, and the enzymolysis material is obtained;

[0050]...

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PUM

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Abstract

The invention provides an extraction method of Panax notoginseng total saponins, which relates to the technical field of traditional Chinese medicine extraction. The extraction method includes the steps of pretreatment, enzymatic hydrolysis, alcohol extraction and macropore adsorption, and is simple, efficient, and environmentally friendly. The extraction method is simple, efficient, and time-consuming. Through the optimization of enzyme types, enzymatic hydrolysis methods and processes, the efficiency of enzymatic hydrolysis can be fully improved, time is saved, and the efficiency of enzymatic hydrolysis steps is improved. And the higher content of Panax notoginseng total saponins.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine extraction, in particular to a method for extracting total saponins of Panax notoginseng. Background technique [0002] Panax notoginseng is a perennial erect herbaceous plant. Its rhizome and flesh are relatively valuable traditional Chinese medicines. It has the effects of stopping bleeding, dispelling blood stasis, reducing inflammation, relieving pain and nourishing. Its flowers and leaves also have the effect of clearing away heat. Saponins are the main active ingredients of Panax notoginseng, including notoginseng saponin R1, ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1 and ginsenoside Rd, which are mainly used for promoting blood circulation and removing blood stasis, dredging channels and collaterals, and inhibiting platelet aggregation and increasing cerebral blood flow It is often used for cerebrovascular sequelae, central retinal vein occlusion, and anterior cha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61K125/00
CPCA61K36/258A61K2236/19A61K2236/333A61K2236/55
Inventor 梁烽焱黄信张坤张永谦程燕梁志军
Owner GUANGDONG YILI LUODING PHARMA