Application of oroxylin A in preparation of drug for preventing and treating respiratory virus infection

A technology of melaleucain and respiratory system, applied in the direction of respiratory diseases, antiviral agents, drug combinations, etc., can solve the problems of rapid virus mutation, difficult defense effect, and no melaleucain A has yet been seen, and achieve good treatment Action, little side effects

Pending Publication Date: 2020-06-30
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although humans have been aware of respiratory viral infectious diseases for nearly a hundred years, the existing medical technology for defense and treatment of respiratory viral infections (especially highly pathogenic respiratory viruses) is still weak; practice shows that current antiviral Influe

Method used

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  • Application of oroxylin A in preparation of drug for preventing and treating respiratory virus infection
  • Application of oroxylin A in preparation of drug for preventing and treating respiratory virus infection
  • Application of oroxylin A in preparation of drug for preventing and treating respiratory virus infection

Examples

Experimental program
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Effect test

Example Embodiment

[0018] Example 1 Preparation and characterization of total flavonoids of Scutellaria baicalensis Georgi

[0019] Take 1.2Kg of dried scutellaria medicinal material, heat and reflux with 80% ethanol for three times, the first time with 10 times the solvent for 2h, the second and third times with 8 times the solvent for 1.5h, combine the three extracts, and concentrate to Without alcohol taste, the obtained extract is suspended in water. The suspension is adsorbed by the pre-treated AB-8 macroporous adsorption resin, and then eluted with 3 times the column bed volume of distilled water and 6 times the column bed volume of 80% ethanol. Collect the ethanol eluate, concentrate and dry under reduced pressure. The total flavonoids of Scutellaria baicalensis Georgi, the yield is 25.48%. Using Ultra Performance Liquid Chromatography (UPLC), the total flavonoids of this Scutellaria baicalensis Georgi were characterized, including the flavonoids baicalin, baicalein and melaleuca, content o...

Example Embodiment

[0020] Example 2 Therapeutic effect of Melaleuca paper A on influenza A virus-induced acute lung injury

[0021] Forty-eight 5-week-old SPF male BALB / c mice were selected and randomly divided into 6 groups (groups A, B, C, D, E, and F) according to their body weight: group A was the normal control group, and group B was the model group. Groups C, D, E, and F were 100 mg / kg scutellaria total flavonoids, baicalin, baicalein, and pallidin A, 8 in each group. All mice were injected with 0.026ml / 10g of propofol injection into the tail vein, and 30μl of H1N1 virus was infected by nasal drip under anesthesia. The left and right noses were each 15μl. The normal control group was given virus dilution. Two hours after infection, different concentrations of drugs were given orally, 0.1ml / 10g, for 4 days. Groups A and B were given 0.5% CMC-Na. The material was taken 24h after the last administration, that is, on the 4th day (after 96h). The eyeballs were removed and the blood was taken to ...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, relates to an application of oroxylin A in pharmacy, and in particular relates to an application of the traditional Chinese medicine monomer oroxylin A in preparation of a drug for preventing and treating respiratory virus infection. Animal model experiments of acute lung injury induced by influenza A virus confirm thatthe oroxylin A has an obvious therapeutic effect on viral acute lung injury, wherein the effect includes the aspects of reducing the pathological damage of the lungs of experimental mice and reducingthe lung index and lung injury area of the mice, the effect is equivalent to that of the same dose of scutellaria root total flavone and baicalein, and is significantly better than that of the same dose of baicalin, wherein P<0.05. The oroxylin A described in the invention can be used to prepare the drug for preventing and treating the respiratory virus infection.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to the use of the traditional Chinese medicine melaleucain A in pharmacy; in particular, it relates to the use of the traditional Chinese medicine melaleucain A in the preparation of medicines for preventing and treating respiratory virus infection. Background technique [0002] The prior art discloses that respiratory virus infection is highly contagious, has a high mortality rate, spreads rapidly, and is widely prevalent, easily causing a large number of casualties, confusion in the medical and social security system, and massive property losses, causing social panic and the like. According to reports, several large-scale influenza outbreaks in the 20th century and the outbreak of atypical infectious pneumonia (SARS) in 2003 have caused serious consequences to society. Studies have shown that respiratory virus infection can lead to acute lung injury (ALI), which...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P11/00A61P31/12A61K36/539
CPCA61K31/352A61P11/00A61P31/12A61K36/539A61K2236/333A61K2236/51A61K2236/55
Inventor 陈道峰支海娟卢燕朱海燕
Owner FUDAN UNIV
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