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Application of oroxylin A in preparation of drug for preventing and treating respiratory virus infection

A technology of melaleucain and respiratory system, applied in the direction of respiratory diseases, antiviral agents, drug combinations, etc., can solve the problems of rapid virus mutation, difficult defense effect, and no melaleucain A has yet been seen, and achieve good treatment Action, little side effects

Pending Publication Date: 2020-06-30
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although humans have been aware of respiratory viral infectious diseases for nearly a hundred years, the existing medical technology for defense and treatment of respiratory viral infections (especially highly pathogenic respiratory viruses) is still weak; practice shows that current antiviral Influenza virus drugs generally have a variety of toxic and side effects; the virus mutates rapidly, and the vaccine research cycle is long, making it difficult to exert an effective defense effect in time
However, there is no report on the treatment of phyllosperm A for respiratory viral infectious diseases.

Method used

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  • Application of oroxylin A in preparation of drug for preventing and treating respiratory virus infection
  • Application of oroxylin A in preparation of drug for preventing and treating respiratory virus infection
  • Application of oroxylin A in preparation of drug for preventing and treating respiratory virus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Preparation and characterization of the total flavonoids of Scutellaria baicalensis of embodiment 1

[0019] Take 1.2Kg of dried Scutellaria baicalensis, heat and reflux with 80% ethanol for three times, extract with 10 times the amount of solvent for 2 hours for the first time, extract 1.5 hours with 8 times the amount of solvent for the second and third times, combine the three extracts, and concentrate under reduced pressure to No alcohol smell, the obtained extract is suspended in water. The suspension was adsorbed by the pretreated AB-8 macroporous adsorption resin, eluted with distilled water 3 times the volume of the column bed, and 80% ethanol 6 times the volume of the column bed, and the ethanol eluate was collected, concentrated and dried under reduced pressure to obtain The total flavonoids of Scutellaria baicalensis, the yield is 25.48%. Using ultra-high performance liquid chromatography (UPLC), the total flavonoids of this Scutellaria baicalensis were char...

Embodiment 2

[0020] Example 2 Therapeutic Effect of Melaleutin A on Influenza A Virus-Induced Acute Lung Injury

[0021] 48 5-week-old SPF male BALB / c mice were randomly divided into 6 groups (Groups A, B, C, D, E, and F) according to body weight: Group A was the normal control group, group B was the model group, Groups C, D, E, and F received 100 mg / kg of total flavonoids from Scutellaria baicalensis, baicalin, baicalein, and scutellarin A, respectively, with 8 rats in each group. All mice were injected with propofol injection 0.026ml / 10g into the tail vein, and under anesthesia, the mice were infected with 30 μl of H1N1 virus in nasal drops, 15 μl in each of the left and right noses, and the normal control group was given virus dilution. Two hours after the infection, different concentrations of drugs were administered orally according to the groups, 0.1ml / 10g, for 4 days. Groups A and B were given 0.5% CMC-Na. 24 hours after the last administration, that is, samples were taken on the 4...

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, relates to an application of oroxylin A in pharmacy, and in particular relates to an application of the traditional Chinese medicine monomer oroxylin A in preparation of a drug for preventing and treating respiratory virus infection. Animal model experiments of acute lung injury induced by influenza A virus confirm thatthe oroxylin A has an obvious therapeutic effect on viral acute lung injury, wherein the effect includes the aspects of reducing the pathological damage of the lungs of experimental mice and reducingthe lung index and lung injury area of the mice, the effect is equivalent to that of the same dose of scutellaria root total flavone and baicalein, and is significantly better than that of the same dose of baicalin, wherein P<0.05. The oroxylin A described in the invention can be used to prepare the drug for preventing and treating the respiratory virus infection.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to the use of the traditional Chinese medicine melaleucain A in pharmacy; in particular, it relates to the use of the traditional Chinese medicine melaleucain A in the preparation of medicines for preventing and treating respiratory virus infection. Background technique [0002] The prior art discloses that respiratory virus infection is highly contagious, has a high mortality rate, spreads rapidly, and is widely prevalent, easily causing a large number of casualties, confusion in the medical and social security system, and massive property losses, causing social panic and the like. According to reports, several large-scale influenza outbreaks in the 20th century and the outbreak of atypical infectious pneumonia (SARS) in 2003 have caused serious consequences to society. Studies have shown that respiratory virus infection can lead to acute lung injury (ALI), which...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P11/00A61P31/12A61K36/539
CPCA61K31/352A61P11/00A61P31/12A61K36/539A61K2236/333A61K2236/51A61K2236/55
Inventor 陈道峰支海娟卢燕朱海燕
Owner FUDAN UNIV