Medicinal preparation and preparation method thereof
A pharmaceutical preparation and pharmacy technology, applied in the field of pharmaceutical preparations and their preparation, can solve the problems of water insolubility, increased ALT or AST, increased liver burden, etc., and achieve the effects of reducing the dosage, improving the curative effect, and reducing the metabolic burden on the liver
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Embodiment 1
[0073] 3-Methyl-1-phenyl-2-pyrazolin-5-one 10g, 3-Butyl-1(3H)-isobenzofuranone 12.5g, D-camphor 3g, sulfobutylbeta Sodium cyclodextrin 300g, propylene glycol 414.4g, sodium metabisulfite 5g, appropriate amount of 1mol / L hydrochloric acid.
[0074] Preparation:
[0075] Step 1, preparation of 3-butyl-1(3H)-isobenzofuranone medicinal solution:
[0076] ①Take 10L of water for injection, heat it to 30°C, slowly add the prescribed amount of sulfobutylbeta cyclodextrin sodium into it, stir until completely dissolved, and prepare the sulfobutylbeta cyclodextrin solution;
[0077] ②While stirring, slowly add the prescribed amount of raw material 3-butyl-1(3H)-isobenzofuranone, stir until the solution is clear and transparent, add water for injection to 30L, and prepare 3-butyl-1(3H) -isobenzofuranone solution, for subsequent use.
[0078] Step 2. Preparation of triple compound injection containing 3-methyl-1-phenyl-2-pyrazolin-5-one, 3-butyl-1(3H)-isobenzofuranone and dexbornyl alc...
Embodiment 2
[0085] 3-methyl-1-phenyl-2-pyrazolin-5-one 5g, 3-butyl-1(3H)-isobenzofuranone 12.5g, dexbornyl alcohol 3g, sulfobutylbeta Cyclodextrin sodium 600g, propylene glycol 363.5g, sodium metabisulfite 7.5g, 1mol / L sodium hydroxide aqueous solution in proper amount.
[0086] Preparation
[0087] Step 1, preparation of 3-butyl-1(3H)-isobenzofuranone medicinal solution:
[0088] ①Take 12L of water for injection, heat it to 25°C, slowly add the prescribed amount of sulfobutylbeta cyclodextrin sodium into it, stir until completely dissolved, and prepare the sulfobutylbeta cyclodextrin solution;
[0089] ②While stirring, slowly add the prescribed amount of raw material 3-butyl-1(3H)-isobenzofuranone, stir until the solution is clear and transparent, add water for injection to 30L, and prepare 3-butyl-1(3H) -isobenzofuranone solution, for subsequent use.
[0090]Step 2. Preparation of triple compound injection containing 3-methyl-1-phenyl-2-pyrazolin-5-one, 3-butyl-1(3H)-isobenzofuranone...
Embodiment 3
[0097] 3-methyl-1-phenyl-2-pyrazolin-5-one 5g, 3-butyl-1(3H)-isobenzofuranone 6.25g, dexbornyl alcohol 6g, sulfobutylbeta Cyclodextrin sodium 500g, propylene glycol 515.6g, sodium metabisulfite 6.3g, 1mol / L hydrochloric acid in proper amount.
[0098] Preparation
[0099] Step 1, preparation of 3-butyl-1(3H)-isobenzofuranone medicinal solution:
[0100] ①Take 9L of water for injection, heat it to 35°C, slowly add the prescribed amount of sulfobutylbeta cyclodextrin sodium into it, stir until completely dissolved, and prepare the sulfobutylbeta cyclodextrin solution;
[0101] ②While stirring, slowly add the prescribed amount of raw material 3-butyl-1(3H)-isobenzofuranone, stir until the solution is clear and transparent, add water for injection to 30L, and prepare 3-butyl-1(3H) -isobenzofuranone solution, for subsequent use.
[0102] Step 2. Preparation of triple compound injection containing 3-methyl-1-phenyl-2-pyrazolin-5-one, 3-butyl-1(3H)-isobenzofuranone and dexbornyl a...
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