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Laparotomy composite biological protection material

A technology of protecting material and abdominal cavity is applied in the field of composite biological protection material for abdominal cavity opening, which can solve the problem of no obvious improvement in late complications, and achieve the effects of delaying the occurrence time of immune rejection, reducing product antigenicity, and high social and economic benefits.

Inactive Publication Date: 2020-07-03
JIANGXI KEXING BIOLOGICAL ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The applicant had tried heterogeneous dressings for early protection, but there was no significant improvement in later complications

Method used

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  • Laparotomy composite biological protection material
  • Laparotomy composite biological protection material
  • Laparotomy composite biological protection material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] The preparation of embodiment 1 biological amnion

[0010] (1) The placenta obtained after delivery should be aseptically removed within 1 hour to remove the amniotic tissue;

[0011] (2) Use 0.6% glutaraldehyde solution to clean the blood and other impurities on the amniotic membrane, put it into a sterile PP bottle filled with 0.1% polysorbate 80 solution; put it in -40°C for at least 18 hours before use ;

[0012] (3) For production and use, thaw at 4°C for 20 hours;

[0013] (4) Take out the amniotic membrane in a sterile environment, put it into 400ml A solution and wash it 4 times;

[0014] (5) Spread the amniotic membrane on a sterile PP board to remove mucus in the basal layer;

[0015] (6) Soak for 60 minutes with a phosphate buffer solution of pH 7.0;

[0016] (7) Rub and wash with 0.6% glutaraldehyde solution for 30 minutes;

[0017] (8) Lay the amniotic membrane between two layers of sterile nylon mesh, and cut it to a suitable size;

[0018] (9) Pack ...

Embodiment 2

[0019] The preparation of embodiment 2 allogeneic dressings

[0020] (1) Take out the allogeneic skin raw materials that have passed the acceptance test and have been frozen at -80°C, and thaw them with 37°C CA solution in a Class 10,000 clean room, and then wash them twice with purified water for 25 minutes each time;

[0021] (2) 0.1% polysorbate 80 solution was treated 3 times, each time for 25 minutes, and then purified water was washed 2 times, each time for 25 minutes;

[0022] (3) Phosphate buffer solution of pH 7.0 was treated twice, each time for 25 minutes, and then purified water was washed twice, each time for 25 minutes;

[0023] (4) Washing twice with a 0.9% sodium chloride solution with a pH of 7.3, each time for 25 minutes;

[0024] (5) After adding an appropriate amount of 0.9% sodium chloride solution, double-layer sealed packaging; 30KGy irradiation sterilization.

Embodiment 3

[0025] Example 3 The use of open composite biological protection materials in the abdominal cavity

[0026] When the protective material is used, the biological amniotic membrane is applied near the innermost layer of the abdominal wall defect, and the allogeneic dressing is covered on it and sutured. According to the degree of injury, the biological amniotic membrane is set to 1-6 layers, and the heterogeneous dressing is set to a single layer.

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Abstract

The invention discloses a laparotomy composite biological protection material. The material consists of a biological amniotic membrane and allogeneic dressing skin. The product provided by the invention is an early protection material for laparotomy, other components of the amniotic membrane are retained while immunogenicity is reduced, adhesion between the protection material and an exposed intestinal tract can be reduced, and convenience is provided for final re-surgical determination of abdomen closure; meanwhile, the allogeneic dressing skin is used as a temporary wound cover to effectively block the external contact, thereby maintaining the liquid environment of the wound surface, creating a suitable pH value, humidity and temperature for recipient cell proliferation and vascularization, and achieving excellent and unique effects in anti-exudation and anti-infection aspects. The material is a composite material, and through the preparation of the material, the nationalization of the biological amniotic membrane and the allogeneic dressing skin can be realized, and relatively high social and economic benefits are achieved.

Description

technical field [0001] The invention belongs to the technical field of medical material preparation, and in particular relates to a composite biological protection material for opening the abdominal cavity. Background technique [0002] Abdominal infection and abdominal trauma may be accompanied by blood coagulation function and multi-organ (liver, central nervous system) dysfunction, so open abdominal therapy must be performed. Open abdominal therapy can reduce intra-abdominal pressure, prevent abdominal compartment syndrome, and prevent and treat multiple organ dysfunction. It is also convenient for surgeons to remove infected necrotic tissue in time at the bedside, unobstructed drainage, and discover complications such as bleeding and intestinal fistula at any time. Complications of open abdominal therapy follow and are difficult to avoid. The best outcome of abdominal opening is early full-thickness fascial suture closure, that is, after the short-term therapeutic purpo...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/14
CPCA61L31/005A61L31/14
Inventor 衷志鹏李幼生
Owner JIANGXI KEXING BIOLOGICAL ENG CO LTD
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