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Spectinomycin hydrochloride lincomycin hydrochloride soluble powder which can be miscible with oil emulsion vaccine after being dissolved in water, and preparation method thereof

A technology of spectinomycin hydrochloride and spectinomycin, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, powder delivery, etc., and can solve the problems of low bioavailability, poor dissolution effect, and use Problems such as high cost, achieve the effect of reducing irritation, improving stability, and overcoming low bioavailability

Active Publication Date: 2020-07-10
山东迅达康兽药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of lincomycin hydrochloride soluble powder which can be miscible with oil seedlings after being dissolved in water and its preparation method, so as to solve the problem of dissolving in oil seedling diluent, poor dissolving effect and low uniformity in the prior art , low bioavailability and high cost of use

Method used

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  • Spectinomycin hydrochloride lincomycin hydrochloride soluble powder which can be miscible with oil emulsion vaccine after being dissolved in water, and preparation method thereof
  • Spectinomycin hydrochloride lincomycin hydrochloride soluble powder which can be miscible with oil emulsion vaccine after being dissolved in water, and preparation method thereof
  • Spectinomycin hydrochloride lincomycin hydrochloride soluble powder which can be miscible with oil emulsion vaccine after being dissolved in water, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025]

[0026] Preparation:

[0027] 1) Mix sodium lauryl sulfate, poloxamer 188 and anhydrous dextrose evenly according to the prescription ratio, then pulverize them, pass through a No. 5 sieve, and weigh them for later use;

[0028] 2) Weigh spectinomycin hydrochloride, lincomycin hydrochloride, PVP-K30, citric acid, disodium ethylenediaminetetraacetic acid, urea, and mix with the ingredients described in 1) uniformly through a three-dimensional mixer.

Embodiment 2

[0030]

[0031] Preparation:

[0032] 1) Mix sodium lauryl sulfate and anhydrous dextrose evenly according to the prescription ratio, then pulverize them, pass through a No. 5 sieve, and weigh them for later use;

[0033] 2) Weigh spectinomycin hydrochloride, lincomycin hydrochloride, PVP-K30, citric acid, disodium ethylenediaminetetraacetic acid, urea, and mix with the ingredients described in 1) uniformly through a three-dimensional mixer.

Embodiment 3

[0035]

[0036] Preparation:

[0037] 1) Mix Poloxamer 188 and anhydrous dextrose evenly according to the prescription ratio, pulverize them, pass through a No. 5 sieve, and weigh them for later use;

[0038] 2) Weigh spectinomycin hydrochloride, lincomycin hydrochloride, PVP-K30, citric acid, disodium ethylenediaminetetraacetic acid, urea, and mix with the ingredients described in 1) uniformly through a three-dimensional mixer.

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Abstract

The invention discloses a spectinomycin hydrochloride lincomycin hydrochloride soluble powder which can be miscible with an oil emulsion vaccine after being dissolved in water, and belongs to the technical field of veterinary medicine preparations. The composition of the spectinomycin hydrochloride lincomycin hydrochloride soluble powder which can be miscible with an oil emulsion vaccine after being dissolved in water is as follows: 40 parts of spectinomycin hydrochloride, 20 parts of lincomycin hydrochloride, 2-4 parts of an emulsifier, 1.5-2.5 parts of a dispersant, 5-10 parts of a buffer, 0.5-1.0 part of a stabilizer, and 22.5-31 parts of an auxiliary material. After being dissolved in water, the soluble powder of the invention does not require any oil emulsion vaccine dilution solutionand can realize uniform mixing with an oil emulsion vaccine. The problems in the prior art that an oil emulsion vaccine dilution solution is needed for dissolution, the dissolution effect is poor, uniformity is low, a biological utilization rate is low, the use cost is relatively high, and the like are solved. On the basis of ensuring the quality and curative effects of such products, the clinical operation and application of breeding is facilitated, and the use cost is reduced.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, and in particular relates to a lincomycin hydrochloride soluble powder which can be miscible with oil seedlings after being dissolved in water and a preparation method thereof. Background technique [0002] Lincomycin (lincomycin) is a lincosamide antibiotic, which has a strong antibacterial effect on most anaerobic bacteria and Gram-positive bacteria. Spectinomycin is an aminoglycoside antibiotic that has specific inhibitory effects on Gram-positive bacteria, negative bacteria and mycoplasma. The combination of lincomycin hydrochloride and spectinomycin hydrochloride has a synergistic effect, a wide antibacterial spectrum, rapid action, and small toxic and side effects. The therapeutic dose has no adverse effects on chickens, pigs and other farmed animals. It is effective against chicken chronic respiratory diseases caused by mycoplasma. Both diarrhea and enteritis caused b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61K31/357A61K9/14A61K47/18A61P31/04
CPCA61K9/145A61K31/357A61K31/7056A61P31/04A61K2300/00
Inventor 汪安国田玉虎李凤华
Owner 山东迅达康兽药有限公司
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