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Application of growth hormone-releasing hormone agonist GHRH-A in preparation of anti-aging drug

A GHRH-A, growth-promoting hormone technology, applied in the field of biomedicine, can solve the problems of unknown mechanism, pathway, undisclosed mechanism, pathway and experimental data, etc., to reduce the positive rate of staining, improve the shape and function of mitochondria, and promote The effect of hair growth

Active Publication Date: 2020-07-14
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it only briefly mentioned this effect in the patent, but did not disclose the specific mechanism, pathway and experimental data
Therefore, those skilled in the art still cannot know its specific mechanism, pathway etc.

Method used

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  • Application of growth hormone-releasing hormone agonist GHRH-A in preparation of anti-aging drug
  • Application of growth hormone-releasing hormone agonist GHRH-A in preparation of anti-aging drug
  • Application of growth hormone-releasing hormone agonist GHRH-A in preparation of anti-aging drug

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Embodiment

[0056] The present invention will be described through specific examples below. The GHRH-A used in this example is MR409, but the protection scope of the present invention is not limited thereto. The experimental methods described in the following examples, unless otherwise specified, are conventional methods; the reagents and materials, unless otherwise specified, can be obtained from commercial sources. Among them, MR409 is provided by Professor AndrewV.Schally of the University of Miami.

[0057] The amino acid sequence of MR409 is: N-Me-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Orn-Val-Leu-Abu-Gln-Leu-Ser-Ala-Arg -Orn-Leu -Leu-Gln-Asp-Ile-Nle-Asp-Arg-NHCH 3 . (i.e. N-methyltyrosine-D-alanine-aspartic acid-alanine-isoleucine-phenylalanine-threonine-asparagine-serine-tyrosine-arginine amino acid-ornithine-valine-leucine-2-aminobutyric acid-glutamine-leucine-serine-alanine-arginine-ornithine-leucine-leucine - Glutamine - Aspartic Acid - Isoleucine - Norleucine - Aspar...

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Abstract

The invention relates to the field of biological medicines, and discloses application of a growth hormone-releasing hormone agonist (GHRH-A) in preparation of an anti-aging drug. The invention finds that the GHRH-A can resist aging, including reducing the positive rate of aging marker (-gal staining, reducing the expression of related protein p21 in the cell cycle of aging cells, and reducing ROSproduction. The GHRH-A improves the mitochondrial morphology and functions of senescent cells, and improves the expression of mitochondrial protein OPA1 and the ratio L / S-OPA1 of the long mitochondrial protein OPA1 to the short mitochondrial protein OPA1; the GHRH-A improves the cardiac function, that is, improves the systolic and diastolic functions; meanwhile, the GHRH-A can improve the proportion and immunocompetence of body immune cells; the GHRH-A increases the number of stem cells; and the GHRH-A improves the body movement ability, promotes hair growth and improves the survival rate. Thedrug has the characteristics of good stability and high medicine activity, and is suitable for preventing and treating heart failure, relieving senescence systemic phenotype and prolonging the service life.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to the application of GHRH-A, a somatotropin-releasing hormone agonist, in the preparation of anti-aging drugs. Background technique [0002] Aging, also known as aging, is a natural and complex biological process that is a common feature of all animals. With the growth of age, the degenerative changes of physiological structure and functional decline appear in the aging body, and corresponding changes occur in the animal body from the levels of organs, tissues, cells, and molecules. The heart is an important organ that is greatly affected by age. In recent years, the aging of the population has become an important trend, and the ensuing elderly heart becomes left ventricular hypertrophy, diastolic dysfunction, atrial fibrillation, and thickening and hardness of the intima of the blood vessels that increase with age. In addition, studies have shown that pathological hypertrophy,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/25A61P39/06
CPCA61K38/25A61P39/06
Inventor 余红项平平A·V·沙利
Owner ZHEJIANG UNIV
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