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Titanium-based active bone implant with ROS response and preparation method of implant

A bone implantation and active technology, applied in the direction of prosthesis, coating, tissue regeneration, etc., can solve problems such as lack of integration of surrounding bone tissue, early material loosening and displacement, and surgical failure, etc., to achieve easy-to-operate preparation methods, Good osteogenic differentiation, excellent osseointegration effect

Active Publication Date: 2020-07-17
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inert titanium dioxide surface makes it lack of integration with the surrounding bone tissue, especially in pathological implant microenvironments, such as in patients with osteoporosis, due to the low bone mass and high fragility of their bones, it is easier to Early loosening and displacement of material occurs, leading to surgical failure

Method used

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  • Titanium-based active bone implant with ROS response and preparation method of implant
  • Titanium-based active bone implant with ROS response and preparation method of implant
  • Titanium-based active bone implant with ROS response and preparation method of implant

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Preparation of ROS-responsive titanium-based active bone implants (Ti / HA / OGP / Apt)

[0041] (1) Preparation of titanium sheets (Ti / HA) with hydroxyapatite deposited on the surface:

[0042] Polish the pure titanium sheet (diameter: 15mm; thickness: 3mm) with 400#, 1000#, 2000# sandpaper in sequence, then ultrasonically clean it with lye, absolute ethanol, and deionized water for 30 minutes, and then use hydrofluoric acid / nitric acid solution etching for 3min, so that the pure titanium sheet after ultrasonic cleaning has a rough topological structure. Finally, the etched pure titanium sheet is used as the cathode of the electrochemical reaction, and the platinum sheet is used as the anode. Cathodic oxidation in electrolyte solution of calcium chloride, ammonium dihydrogen phosphate, sodium chloride and sodium citrate;

[0043] (2) preparation of borate bond;

[0044] A. Dissolve 0.47g of p-nitrobenzoic chloroformate in 15mL of tetrahydrofuran, and fill with nitrogen at...

Embodiment 2

[0050] Fabrication of ROS-responsive titanium-based active bone implants

[0051] (1) Preparation of titanium sheets with hydroxyapatite deposited on the surface:

[0052] Polish the pure titanium sheet (diameter: 15mm; thickness: 3mm) with 400#, 1000#, 2000# sandpaper in sequence, then ultrasonically clean it with lye, absolute ethanol, and deionized water for 20 minutes, and then use hydrofluoric acid / nitric acid solution etching for 3min, so that the pure titanium sheet after ultrasonic cleaning has a rough topological structure. Finally, the etched pure titanium sheet is used as the cathode of the electrochemical reaction, and the platinum sheet is used as the anode. Cathodic oxidation in electrolyte solution of calcium chloride, ammonium dihydrogen phosphate, sodium chloride and sodium citrate;

[0053] (2) preparation of borate bond;

[0054] A. Dissolve 0.47g of p-nitrobenzoic chloroformate in 15mL of tetrahydrofuran, and fill with nitrogen at 0°C to obtain solution ...

Embodiment 3

[0060] Fabrication of ROS-responsive titanium-based active bone implants

[0061] (1) Preparation of titanium sheets with hydroxyapatite deposited on the surface:

[0062] Polish the pure titanium sheet (diameter: 15mm; thickness: 3mm) with 400#, 1000#, 2000# sandpaper in sequence, then ultrasonically clean it with lye, absolute ethanol, and deionized water for 40 minutes, and then use hydrofluoric acid / nitric acid solution etching for 3min, so that the pure titanium sheet after ultrasonic cleaning has a rough topological structure. Finally, the etched pure titanium sheet is used as the cathode of the electrochemical reaction, and the platinum sheet is used as the anode. Cathodic oxidation in electrolyte solution of calcium chloride, ammonium dihydrogen phosphate, sodium chloride and sodium citrate;

[0063] (2) preparation of borate bond;

[0064] A. Dissolve 0.47g of p-nitrobenzoic chloroformate in 15mL of tetrahydrofuran, and fill with nitrogen at 0°C to obtain solution ...

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Abstract

The invention relates to a titanium-based active bone implant with ROS response and a preparation method of the implant, and belongs to the technical field of medical materials. The preparation methodof the implant includes the four steps of preparing a titanium sheet with hydroxyapatite deposited on the surface, preparing a borate bond, preparing a borate bond-osteogenic growth peptide complex,and preparing the implant. The bone implant provided by the invention has the advantages of pertinence, intelligence, and better biocompatibility and osseointegration, compared with a traditional biomaterial modification method, the release amount of Apt 19S in the bone implant can reach an optimal recruitment concentration of MSCs within 24 h, and in-vivo and in-vitro experiments further prove that a titanium substrate modified with Apt 19S can migrate the MSCs to a bone defect site, has better ability to promote osteogenic differentiation of bone-related cells, and accelerates bone repair. The preparation method of the titanium-based active bone implant with the ROS response is simple and easy to operate, and is suitable for expanded production.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a titanium-based active bone implant with ROS response and a preparation method thereof. Background technique [0002] Medical titanium-based materials are widely used in clinical operations based on their good mechanical properties, corrosion resistance and biocompatibility. However, the inert titanium dioxide surface makes it lack of integration with the surrounding bone tissue, especially in pathological implant microenvironments, such as in patients with osteoporosis, due to the low bone mass and high fragility of their bones, it is easier to Early loosening and displacement of material occurs, leading to surgical failure. [0003] In order to improve the integration of the implant with the surrounding bone tissue, many physical methods (such as ion implantation, physical vapor deposition), chemical methods (such as acid-base corrosion, anodic oxidation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/32A61L27/50A61L27/54A61L27/34A61L27/28
CPCA61L27/06A61L27/32A61L27/50A61L27/54A61L27/34A61L27/28A61L2430/02A61L2300/258A61L2300/412C08L89/00
Inventor 胡燕孙钰婷陈茂华罗忠蔡开勇
Owner CHONGQING UNIV
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