Medical hydrogel and preparation method thereof

A hydrogel and medical technology, applied in the field of medical hydrogel and its preparation, can solve the problems such as the inability to balance mechanical properties and biocompatibility, and achieve the effects of good clinical application prospects, excellent mechanical properties, and simple operation.

Inactive Publication Date: 2020-07-17
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a medical hydrogel with strong mechanical properties, excellent biocompatibility, and good degradation performance, aiming to solve the problem that the existing medical hydrogels cannot balance the mechanical properties and biocompatibility

Method used

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  • Medical hydrogel and preparation method thereof

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preparation example Construction

[0019] The embodiment of the present invention provides a preparation method of medical hydrogel, comprising the following steps:

[0020] S01. providing an acidic aqueous solution of gelatin;

[0021] S02. Adding a coupling agent to the acidic aqueous solution of gelatin to carry out the first crosslinking reaction to obtain a gelatin / coupling agent solution, wherein the coupling agent is a silane coupling agent containing amino and / or epoxy bonds ;

[0022] S03. Put the gelatin / coupling agent solution at 1-4°C to obtain a gelatin / silica hybrid hydrogel;

[0023] S04. Soak the gelatin / silicon dioxide hybrid hydrogel in a specific salt solution, so that the gelatin in the gelatin / silicon dioxide hybrid hydrogel is spontaneously cross-linked, and after soaking for 1-2 days, in Drying at room temperature for 2-3 days to obtain gelatin / silicon dioxide toughened hydrogel, wherein the specific salt solution is formed by sulfate, monohydrogen phosphate, dithiosulfate anions and am...

Embodiment 1

[0050] A preparation method of medical hydrogel, comprising the following steps:

[0051] S11. Under the condition of 38-55°C, add gelatin powder into 0.01N HCl solution, carry out stirring reaction, and prepare an acidic aqueous solution of gelatin;

[0052] S12. At 50°C, in the acidic gelatin solution, add GPTMS dropwise, stir and react at 450 rpm for 6-14 hours, and perform the first cross-linking reaction to obtain a gelatin / coupling agent solution;

[0053] S13. Standing the gelatin / coupling agent solution at 1-4°C to obtain a gelatin / silica hybrid hydrogel;

[0054] S14. At room temperature, add a specific salt such as ammonium sulfate powder in ultrapure water, and carry out a stirring reaction to prepare a sulfate ion solution; soak the gelatin / silicon dioxide hybrid hydrogel in the sulfate ion solution, The gelatin in the gelatin / silicon dioxide hybrid hydrogel is spontaneously cross-linked, soaked for 1-2 days, and then dried at room temperature for 2-3 days to obta...

Embodiment 2

[0056] A preparation method of medical hydrogel, comprising the following steps:

[0057] S11. Under the condition of 38-55°C, add gelatin powder into 0.01N HCl solution, carry out stirring reaction, and prepare an acidic aqueous solution of gelatin;

[0058] S12. At 50°C, in the acidic gelatin solution, add GPTMS dropwise, stir and react at 450 rpm for 6-14 hours, and perform the first cross-linking reaction to obtain a gelatin / coupling agent solution;

[0059] S13. Put the gelatin / coupling agent solution at 1-4°C to obtain a gelatin / silica hybrid hydrogel; add the hydrolyzed orthosilicate solution to the gelatin / coupling agent In the solvent solution, stir and react for 15-60min at a rotation speed of 450rpm to obtain a hydrogel hybrid system;

[0060] S14. At room temperature, add a specific salt such as ammonium sulfate powder to ultrapure water, and carry out a stirring reaction to prepare a sulfate ion solution; soak the hydrogel hybrid system in the sulfate ion solutio...

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Abstract

The invention provides a preparation method of medical hydrogel. The preparation method comprises the following steps: providing an acidic aqueous solution of gelatin; adding a coupling agent into theacidic aqueous solution of gelatin to carry out a first crosslinking reaction to obtain a gelatin / coupling agent solution, wherein the coupling agent is a silane coupling agent containing amino and / or epoxy bonds; standing the gelatin / coupling agent solution at 1-4 DEG C to obtain a gelatin / silica hybrid hydrogel; and soaking the gelatin / silica hybrid hydrogel in a specific salt solution for 1-2days, and performing drying at room temperature for 2-3 days to obtain the gelatin / silica toughened hydrogel, wherein the specific salt solution is a salt solution formed by sulfate radicals, monohydrogen phosphate radicals, dithiosulfate anions, ammonium ions and sodium ions.

Description

technical field [0001] The invention belongs to the field of hydrogel technology, in particular to a medical hydrogel and a preparation method thereof. Background technique [0002] Cartilage defect is a common clinical orthopedic disease, arthroscopy found that about 60% of the joints have cartilage defects. If not treated in time, 60%-75% of the lesions can progressively develop into osteoarthritis, seriously affecting the patient's motor function, and even ending his career. Since articular cartilage is not vascularly innervated, its regenerative capacity is very limited. Therefore, in the fields of biomaterials and medicine, cartilage defect repair has always been a research hotspot. So far, cartilage defect repair has not been effectively solved. As the gold standard for the treatment of articular cartilage defects, autologous chondrocyte transplantation has been recognized by scholars, but there are problems such as limited source of seed cells and secondary surgery...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/50A61L27/22A61L27/02C08J3/075C08L89/00C08K3/36
CPCA61L27/025A61L27/222A61L27/50A61L27/52A61L2430/06C08J3/075C08J2389/00C08K3/36
Inventor 王大明劳长石陈张伟刘长勇傅岳龙程星
Owner SHENZHEN UNIV
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