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Anti-bacterial hydrophilic nanofiber membrane and preparation method thereof

A nanofiber membrane and fiber membrane technology, applied in the directions of pharmaceutical formulations, bandages, drug delivery, etc., can solve the problem of low production efficiency of nanofiber membranes, and achieve the effects of facilitating the operation of medical staff, good antibacterial effect, and improving safety.

Active Publication Date: 2020-07-28
无菌时代复合新材料(苏州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The application provides an antibacterial hydrophilic nanofiber membrane and its preparation method, which solves the problem of low production efficiency of nanofiber membranes prepared by electrospinning in the past, improves the safety of the production process, and obtains fiber membranes with good Antibacterial properties, and the temperature-sensitive high molecular polymer is added to the spinning raw material, the dressing can be changed more easily by changing the temperature, which is beneficial to the operation of medical staff and reduces the suffering of patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method for preparing an antibacterial hydrophilic fiber nano-membrane, comprising the steps of:

[0027] (1) Get a certain mass concentration of polyvinyl alcohol solution, add chitosan solution therein, and obtain the chitosan solution of polyvinyl alcohol through stirring; wherein the mass ratio of polyvinyl alcohol solution and chitosan solution is 1:3 ;

[0028] (2) Take poly-N-isopropylacrylamide PNIPAAm and dissolve it in a solvent, wherein the molecular weight of poly-N-isopropylacrylamide is 5000;

[0029] (3) Mix step (1) and step (2) to obtain a mixed solution, and add an appropriate amount of polyvinylpyrrolidone PVP;

[0030] (4) Solution jet spinning: put the spinning solution obtained in step (3) into the spinning solution cavity, and pass the metering pump to extrude the spinning solution through the spinneret hole, and under the action of the annular high-speed airflow , form nanofibers, and collect on the receiving plate to form a nanofi...

Embodiment 2

[0037] A preparation method for preparing an antibacterial hydrophilic fiber nano-membrane, comprising the steps of:

[0038] (1) Get the polyvinyl alcohol solution of certain mass concentration, add chitosan solution wherein, obtain the chitosan solution of polyvinyl alcohol through stirring; Wherein the mass ratio of polyvinyl alcohol solution and chitosan solution is 3:7 ;

[0039] (2) Take poly-N-isopropylacrylamide PNIPAAm and dissolve it in a solvent, wherein the molecular weight of poly-N-isopropylacrylamide is 30000;

[0040] (3) Mix step (1) and step (2) to obtain a mixed solution, and add an appropriate amount of polyvinylpyrrolidone PVP;

[0041] (4) Solution jet spinning: put the spinning solution obtained in step (3) into the spinning solution cavity, and pass the metering pump to extrude the spinning solution through the spinneret hole, and under the action of the annular high-speed airflow , form nanofibers, and collect on the receiving plate to form a nanofib...

Embodiment 3

[0048] A preparation method for preparing an antibacterial hydrophilic fiber nano-membrane, comprising the steps of:

[0049] (1) Get the polyvinyl alcohol solution of certain mass concentration, add chitosan solution wherein, obtain the chitosan solution of polyvinyl alcohol through stirring; Wherein the mass ratio of polyvinyl alcohol solution and chitosan solution is 2:5 ;

[0050] (2) Take poly-N-isopropylacrylamide PNIPAAm and dissolve it in a solvent, wherein the molecular weight of poly-N-isopropylacrylamide is 20000;

[0051] (3) Mix step (1) and step (2) to obtain a mixed solution, and add an appropriate amount of polyvinylpyrrolidone PVP;

[0052] (4) Solution jet spinning: put the spinning solution obtained in step (3) into the spinning solution cavity, and pass the metering pump to extrude the spinning solution through the spinneret hole, and under the action of the annular high-speed airflow , form nanofibers, and collect on the receiving plate to form a nanofib...

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Abstract

The invention provides an anti-bacterial hydrophilic nanofiber membrane. Chitosan, polyvinyl alcohol, poly(N-isopropyl acrylamide) and polyvinylpyrrolidone are included in the fiber membrane, whereinthe mass ratio of chitosan to polyvinyl alcohol to poly(N-isopropyl acrylamide) to polyvinylpyrrolidone is (0.1-1):(1-3):(10-20):(3-6). The anti-bacterial hydrophilic nanofiber membrane is obtained through a solution jet spinning preparation method; compared with traditional electrostatic spinning, production efficiency is improved by 3-5 times, operation is simple, and safety performance in the production process is high; and chitosan with the anti-bacterial effect is included in fibers, the good anti-bacterial effect is achieved, temperature sensitive polymer PNIPAAm is adopted, dressings can be replaced more easily by changing temperatures, operation of medical staff is facilitated, and the pain of patients is relieved.

Description

technical field [0001] The invention relates to medical materials, in particular to an antibacterial hydrophilic nanofiber membrane. Background technique [0002] The antibacterial properties of dressings affect the healing of wounds to a certain extent. As dressing materials, nanofiber membranes with antibacterial effects have many advantages that other materials cannot match, such as high specific surface area and porosity. It is one of the important research directions at present. one. [0003] Solution jet spinning, as an emerging spinning technology, has broad application prospects in the preparation of nanofibers. It uses high-speed airflow as the driving force. After the polymer solution is extruded through the spinneret holes, it is driven by high-speed airflow. The polymer jet is formed under the process of reaching the receiving device, the jet is further drawn and refined, accompanied by the volatilization and unstable movement of the solvent, and the nano-scale ...

Claims

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Application Information

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IPC IPC(8): D04H1/732D04H1/4391D04H1/4382A61L15/42A61L15/46A61L15/24A61L15/28
CPCD04H1/732D04H1/4391D04H1/4382A61L15/42A61L15/46A61L15/225A61L2400/12A61L2300/232A61L2300/404C08L5/08C08L29/04C08L39/06C08L33/24
Inventor 张瑾冯慧慧
Owner 无菌时代复合新材料(苏州)有限公司