Application of isopentenyl substituted phenol compound in resisting staphylococcus aureus and methicillin-resistant staphylococcus aureus

A phenolic compound and methicillin-resistant technology, applied in the fields of medicine and microbial chemistry, can solve the problems of limited drug development and research work

Active Publication Date: 2020-08-07
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the drug development research...

Method used

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  • Application of isopentenyl substituted phenol compound in resisting staphylococcus aureus and methicillin-resistant staphylococcus aureus
  • Application of isopentenyl substituted phenol compound in resisting staphylococcus aureus and methicillin-resistant staphylococcus aureus
  • Application of isopentenyl substituted phenol compound in resisting staphylococcus aureus and methicillin-resistant staphylococcus aureus

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0032] Example 1: The anti-staphylococcus aureus and methicillin-resistant staphylococcus aureus activities of the compounds of formula I-IV were tested by the McDonald's turbidimetric method recommended by the National Clinical Trial Center

[0033] (1) Configuration of liquid and solid medium

[0034] Preparation method of nutrient broth medium: weigh 18g of dry nutrient broth (Scientific Research Special company, the same below), dissolve in 1000mL of distilled water, and divide into conical flasks, sterilize at 121℃, 0.15MPa high temperature and high pressure for 15min ,spare.

[0035] Nutrient agar medium preparation method: weigh 15g of dry agar powder (Guangdong Huankai Microbial Science and Technology Co., Ltd.) and 18g of dry nutrient broth powder, dissolve in 1000mL distilled water, heat to dissolve, and pack into conical flasks, 121℃, 0.15MPa After sterilizing for 15 minutes under high temperature and high pressure, immediately distribute the sterilized nutrient agar medi...

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Abstract

The invention relates to the technical field of medical microbial chemistry. The invention relates to the technical field of biological medicines, and particularly discloses medical application of oneor four isopentenyl substituted phenol compounds separated from a fermentation product of Sclerotium hirsutum in preparation of antibacterial medicines. The invention particularly relates to an application in preparing medicines for inhibiting the growth of staphylococcus aureus and methicillin-resistant staphylococcus aureus. An antibacterial activity test proves that the isopentenyl substitutedphenol compound and the derivative of the isopentenyl substituted phenol compound can be used for remarkably inhibiting staphylococcus aureus and methicillin-resistant staphylococcus aureus (MRSA) and its use as a novel agricultural or medical antibacterial and drug-resistant bacterial drug.

Description

Technical field [0001] The present invention relates to the fields of medicine and microbial chemistry, and in particular to a class of isopentenylated phenolic compounds derived from a strain of Stereumhirsutum (Stereumhirsutum) for preparing for inhibiting Staphylococcus aureus and methicillin-resistant golden yellow grapes Application of cocci growth in medicine. Background technique [0002] Microorganisms have existed on the earth for more than 3.8 billion years and have shown great genetic and metabolic diversity. In order to survive, they continue to evolve to adapt to different environments and competitive challenges. Humans have also been using antibiotics, preservatives and other anti-methicillin-resistant Staphylococcus aureus agents to prevent and control infections. At present, the drug resistance of bacteria, viruses, parasites and other infectious diseases is a huge problem facing the people of the world. Therefore, the development of antibacterial drugs with un...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K31/365A61K31/216A61P31/04
CPCA61K31/216A61K31/352A61K31/365A61P31/04
Inventor 刘吉开陈贺平赵珍珠
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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