Compound pharmaceutical composition for coronary heart disease

A composition and technology for coronary heart disease, which are applied in the directions of drug combinations, cardiovascular system diseases, active ingredients of heterocyclic compounds, etc., can solve the problem that there are no reports on the combined application of atorvastatin calcium and atraliuton in the literature, and no reports in the literature. Compound pharmaceutical composition, the effect of improving inflammation is not obvious, etc., to prevent and treat thrombosis and complications of formation, reduce high-sensitivity C-reactive protein and plasma interleukin, and stabilize the size of the effect.

Active Publication Date: 2020-08-07
THE FIFTH PEOPLES HOSPITAL OF SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current research reports show that atraleutone has a small anti-inflammatory effect, and the improvement effect on inflammation is not obvious, and there is a lack of sufficient large-scale, multi-center clinical research results to confirm the therapeutic value of atraleutone
[0005] At present, there is no document reporting the combined application of atorvastatin calcium and atraleutone, nor is there any document reporting the compound pharmaceutical composition of atorvastatin calcium and atraleutone

Method used

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  • Compound pharmaceutical composition for coronary heart disease
  • Compound pharmaceutical composition for coronary heart disease
  • Compound pharmaceutical composition for coronary heart disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] prescription:

[0078]

[0079]

[0080] Preparation process: Weigh atorvastatin calcium, atrileuton, lactose, carboxymethyl starch sodium, and hypromellose, mix them evenly, add water and mix them to make a soft material, pass through a 20-mesh sieve to make wet granules, and dry at 60°C , 20-mesh sieve, adding magnesium stearate, mixing, tableting, that is.

Embodiment 2

[0082] prescription:

[0083]

[0084] Preparation process: Weigh atorvastatin calcium, atrileuton, lactose, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, and hypromellose, mix them evenly, add water to mix to make a soft material, and pass through a 20-mesh sieve. Wet granules, dried at 60°C, sieved with a 20-mesh sieve, added with magnesium stearate, mixed evenly, pressed into tablets, and obtained.

Embodiment 3

[0086] prescription:

[0087]

[0088]

[0089] Preparation process: Weigh atorvastatin calcium, atrileuton, lactose, starch, sodium carboxymethylcellulose, and hypromellose, mix evenly, add water to mix to make a soft material, pass through a 20-mesh sieve to make wet granules, Dry at 60°C, sieve through a 20-mesh sieve, add talcum powder, mix well, and press into tablets to obtain the product.

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PUM

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Abstract

The invention discloses combined application of atorvastatin calcium and atreleuton in preparation of drugs for treating and preventing coronary heart disease. The invention also provides a compound pharmaceutical composition for treating coronary heart disease. According to the invention, the inhibition effect on inflammation can be improved, hypersensitive C-reactive protein, plasma interleukinand the like can be reduced, the size of coronary plaques can be stabilized, even the effect of reversing plaques can be achieved, the compound pharmaceutical composition can effectively prevent and treat thrombosis and complications of atherosclerotic plaques by inhibiting inflammation, and has a very good protective effect on heart and blood vessels.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and in particular relates to the use of combined administration of atorvastatin calcium and atraleutone for treating coronary heart disease and a compound pharmaceutical composition. Background technique [0002] Coronary heart disease, namely coronary heart disease, mainly refers to a series of clinical symptoms resulting from the accumulation of lipid substances in the arterial intima due to abnormal lipid metabolism to form atherosclerotic lesions. With the improvement of people's living standards, changes in living habits, and the acceleration of the aging society, the incidence of coronary heart disease is increasing, and the risk factors that affect the occurrence and development of coronary heart disease are increasing, seriously endangering human health. At present, the common drugs for the treatment of coronary heart disease mainly include anticoagulant drugs, vasodilator nitrates, ant...

Claims

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Application Information

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IPC IPC(8): A61K31/40A61K31/381A61P9/10
CPCA61K31/40A61K31/381A61P9/10A61K2300/00
Inventor 徐迎佳薛金贵黄日太
Owner THE FIFTH PEOPLES HOSPITAL OF SHANGHAI
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