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An acid environment responsive contrast agent for detecting tumors based on dual-energy CT imaging and its preparation method and application

A technology for CT imaging and environmental response, applied in applications, preparation of X-ray contrast agents, preparations for in vivo experiments, etc., to achieve the effect of improving accuracy and efficient loading

Active Publication Date: 2022-03-22
EYE & ENT HOSPITAL SHANGHAI MEDICAL SCHOOL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there is currently no contrast agent based on dual-energy CT that can significantly improve the accuracy of diagnosis and differential diagnosis of malignant tumors

Method used

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  • An acid environment responsive contrast agent for detecting tumors based on dual-energy CT imaging and its preparation method and application
  • An acid environment responsive contrast agent for detecting tumors based on dual-energy CT imaging and its preparation method and application
  • An acid environment responsive contrast agent for detecting tumors based on dual-energy CT imaging and its preparation method and application

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Experimental program
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Embodiment 1

[0031] Embodiment 1 Preparation of contrast agent of the present invention (1)

[0032] 1) Synthesis of Hf-MOF: 2,2'-bipyridine-5,5'-dicarboxylic acid (bpydc, 50mg, 0.2mmol) and HfCl 4 (64mg, 0.2mmol) was placed in an autoclave containing 20ml of DMF, and 0.93ml of glacial acetic acid was added to it, and the mixture was sonicated for about 10min, then heated in an oven at 120°C for 3d, and cooled to After room temperature, a white solid powder was precipitated, which was centrifuged twice with DMF and washed five times with ethanol to obtain the Hf-MOF material. The material was finally dispersed in 20mL of ethanol and sealed for storage.

[0033] 2) Synthesis of block copolymer: the weighed macromolecular poly(ethylene glycol monomethyl ether methacrylate) POEGMA (0.5g, 0.1mmol), dimethylaminoethyl methacrylate monomer (1.50g , 9.5mmol), acrylic acid monomer (0.23g, 3.2mmol) and initiator azobisisobutyronitrile (1.64mg, 0.01mmol) were dissolved in 10mL dimethyl sulfoxide. ...

Embodiment 2

[0035] Embodiment 2 Preparation of contrast agent of the present invention (two)

[0036] 1) Synthesis of Hf-MOF: 2,2'-bipyridine-5,5'-dicarboxylic acid (bpydc, 50mg, 0.2mmol) and HfCl 4 (64mg, 0.2mmol) was placed in an autoclave containing 20ml of DMF, and 0.93ml of glacial acetic acid was added to it, and the mixture was sonicated for about 10min, then heated in an oven at 120°C for 3d, and cooled to After room temperature, a white solid powder was precipitated, which was centrifuged twice with DMF and washed five times with ethanol to obtain the Hf-MOF material. The material was finally dispersed in 20mL of ethanol and sealed for storage.

[0037] 2) Synthesis of block copolymers: the weighed macromolecular poly(ethylene glycol monomethyl ether methacrylate) POEGMA (0.5g, 0.1mmol), dimethylaminoethyl methacrylate monomer (1.50g , 9.5mmol), acrylic acid monomer (0.23g, 3.2mmol) and initiator azobisisobutyronitrile (1.64mg, 0.01mmol) were dissolved in 10mL dimethyl sulfoxid...

Embodiment 3

[0039] Embodiment 3 Preparation of contrast agent of the present invention (three)

[0040] 1) Synthesis of Hf-MOF: 2,2'-bipyridine-5,5'-dicarboxylic acid (bpydc, 50mg, 0.2mmol) and HfCl 4 (64mg, 0.2mmol) was placed in an autoclave containing 20ml of DMF, and 0.93ml of glacial acetic acid was added to it, and the mixture was sonicated for about 10min, then heated in an oven at 120°C for 3d, and cooled to After room temperature, a white solid powder was precipitated, which was centrifuged twice with DMF and washed five times with ethanol to obtain the Hf-MOF material. The material was finally dispersed in 20mL of ethanol and sealed for storage.

[0041] 2) Synthesis of block copolymers: the weighed macromolecular poly(ethylene glycol monomethyl ether methacrylate) POEGMA (0.5g, 0.1mmol), dimethylaminoethyl methacrylate monomer (1.50g , 9.5mmol), acrylic acid monomer (0.23g, 3.2mmol) and initiator azobisisobutyronitrile (1.64mg, 0.01mmol) were dissolved in 10mL dimethyl sulfox...

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Abstract

The present invention relates to an acid environment response contrast agent for detecting tumors based on dual-energy CT imaging and its preparation method and application. The block copolymer is encapsulated, and the acid environment responsive block copolymer can respond to an acid environment of pH<6.8, and the mass ratio of the Hf-MOF to the iodine-containing CT contrast agent is 1:(3-6.5). The present invention also provides a tumor detection system based on dual-energy CT imaging, which includes the acid environment detection contrast agent, dual-energy CT equipment and a data processing module. The present invention proposes for the first time the detection of tumor acid environment based on dual-energy CT, and prepares a suitable contrast agent, which helps realize sensitive detection of tumors and is of great significance for improving the accuracy of tumor diagnosis.

Description

technical field [0001] The invention relates to the technical field of medical examination reagents, in particular to an acid environment responsive contrast agent for detecting tumors based on dual-energy CT imaging, a preparation method and application thereof. Background technique [0002] With the development of X-ray detectors and imaging systems, dual-energy CT has been widely used. Compared with traditional single-energy CT, dual-energy CT can use material separation imaging to accurately quantify iodine or calcium in tissues. Low keV and high keV single-energy spectrum images can respectively improve image contrast and effectively reduce metal and hardening artifacts , to increase the display rate of lesions. Therefore, dual-energy CT is of great significance in the field of clinical medical diagnosis. Among them, material separation imaging can effectively extract the iodine components in the tissue and obtain an iodine map with pseudo-color, which can directly re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/04A61B6/03
CPCA61K49/0438A61B6/481A61B6/03
Inventor 唐作华步文博姚振威王鹏肖泽彬宫腾王超超王韩
Owner EYE & ENT HOSPITAL SHANGHAI MEDICAL SCHOOL FUDAN UNIV
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