Polypeptide composition with effect of promoting melanogenesis and application thereof

A technology of polypeptide composition and melanin, which is applied in the field of cosmetic peptides, can solve problems such as hair whitening, and achieve the effects of increasing melanin content, preventing damage, and promoting melanin production

Active Publication Date: 2020-08-11
SHENZHEN WINKEY MEDICAL RES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] White hair has attracted widespread attention from consumers all over the world. However, most of the hair pigmentation products currently on the market cannot fundamentally solve the problem of hair graying, but artificially dye the hair shaft exposed above the scalp temporarily. agent

Method used

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  • Polypeptide composition with effect of promoting melanogenesis and application thereof
  • Polypeptide composition with effect of promoting melanogenesis and application thereof
  • Polypeptide composition with effect of promoting melanogenesis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-7

[0104] The preparation method of embodiment 1-7 composition:

[0105] 1. Add 5, 8, and 9 of the prescription amount into purified water, heat to 80°C, and use it as the water phase;

[0106] 2. Add the prescribed amount of 2, 3, 6, and 7 into another container, heat to 80°C, and use it as the oil phase;

[0107] 3. Add the oil phase to the water phase, stir and homogenize for 5-10 minutes to make the emulsion mixed phase I, and then cool down to 40°C;

[0108] 4. Dissolve 11, 12, 14, 16, and 17 completely with 4, and completely dissolve 13 and 15 with the reserved purified water, add mixed phase I, and adjust the pH to 5.0-6.0 with 10, stir well to make a mixed phase II;

[0109] 5. Homogenize the mixed phase II with a high-pressure homogenizer for 3-10 minutes, and it is ready.

Embodiment 1-6

[0135] Examples 1-6, Comparative Examples 1-7, wherein Comparative Example 7 is a blank control, used as a placebo.

[0136] 4.3 Test equipment

[0137] MPA9 skin multifunctional tester (CK company, Germany)

[0138] 4.4 Test principle

[0139] By comparing the changes in the skin color parameter (L*) value of each test sample before and after use, the percentage of color change is calculated, the percentage of color change is compared with the result of the placebo, and the test sample is evaluated according to the magnitude of the decrease in the percentage of color change. , Intensifies and prolongs the tan effect of the skin.

[0140] Skin chromaticity parameter (L*): refers to the brightness value observed by the subject compared with the pure white reference object, where L* (brightness) refers to the range from pure black (L=0) to pure white (L= 100) brightness range.

[0141] 4.5 Test method

[0142] Before the test, the skin L* value was detected at 0 d, and then...

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Abstract

The invention discloses a polypeptide composition with an effect of promoting melanogenesis and application thereof, and belongs to the technical field of cosmetic polypeptides. The composition comprises alpha-MSH bionic peptide and a pre-melanogenesis agent. The polypeptide composition can also be added with a polypeptide capable of improving the cAMP level and/or an active component for promoting tyrosinase gene expression and/or an active component with an antioxidant effect and/or a polypeptide with a hair growth promoting effect. The polypeptide composition disclosed by the invention actson different targets through compounding of different active ingredients, comprehensively plays a synergistic effect, remarkably promotes melanogenesis, and can be used for turning white hair into black hair, turning skin into brown and/or preventing damage caused by ultraviolet irradiation.

Description

technical field [0001] The invention belongs to the technical field of cosmetic polypeptides, and in particular relates to a polypeptide composition capable of promoting melanin production and its application. Background technique [0002] The growth of vertebrate hair includes the growth of hair shaft and the synthesis of melanin. This process requires the cooperation of hair follicle stem cells and melanin stem cells. The melanin stem cells in the hair follicle bulge area are the source cells of hair coloring. The melanocytes in the hair follicle continue to proliferate and differentiate with the cycle of the hair follicle growth cycle, and participate in the cyclical process of the entire hair follicle. Melanocytes have different functions at different stages of the cycle. Melanocytes in the growth phase can synthesize melanin, which can be transported to the surrounding epidermis and hair matrix keratinocytes in the growth phase through the dendrite structure of the me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/44A61Q5/12A61Q19/04A61Q17/04A61P17/00
CPCA61K8/44A61K8/64A61K2800/592A61Q5/12A61Q17/04A61Q19/04A61P17/00
Inventor 丁文锋彭晏张哲黄春青观富宜
Owner SHENZHEN WINKEY MEDICAL RES DEV
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