Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of adsorbing material for blood perfusion

A technology of blood perfusion and adsorption materials, which is applied in the fields of blood circulation treatment, chemical instruments and methods, suction instruments, etc., can solve the problems of complicated synthesis routes, and achieve the effects of improving surface properties, simplifying synthesis routes, and increasing specific surface area.

Active Publication Date: 2020-08-14
XIAN LANSHEN NEW MATERIAL TECHNOLOGY CO LTD +1
View PDF9 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, while functional modification improves the performance of macroporous adsorption resins, it is accompanied by the complexity of synthetic routes.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of adsorbing material for blood perfusion
  • Preparation method of adsorbing material for blood perfusion

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0051] see figure 1 , a method for preparing an absorbent material for hemoperfusion of the present invention, comprising the following steps:

[0052] S1. Prepare oil phase and water phase for suspension polymerization reaction, the mass ratio of oil phase and water phase is 1:1.8-2.2, prepare 0.8%-1.2% dispersant aqueous solution as water phase; mix monomer and crosslinking agent Mixed monomers are configured at a mass ratio of 11 to 19:1, and the mixed monomers, porogens and initiators are formulated as an oil phase according to 1:(0.8~1.2):(0.006~0.012);

[0053] The monomer of the suspension polymerization reaction is one or more of styrene, methylstyrene, ethylstyrene and p-hydroxystyrene.

[0054] The crosslinking agent is one of divinylbenzene, dipropylenebenzene, divinylphenylmethane and trivinylbenzene.

[0055] The porogen is one or more of toluene, xylene, tetramethylbenzene, ethylbenzene, 200# gasoline, kerosene, liquid paraffin, and white oil.

[0056] The ini...

Embodiment 1

[0087] (1) Suspension polymerization

[0088] Mix 260.5g styrene, 39.5g 63.3%wt divinylbenzene, 240.0g white oil and 1.8g benzoyl peroxide evenly, and add 972.0g 1.2%wt gelatin aqueous solution into a 3000mL three-port container with mechanical stirring and a thermometer in the flask. Start the mechanical stirring, slowly raise the temperature to 75°C, keep warm for 4h; then slowly raise the temperature to 85°C, keep warm for 4h; finally slowly raise the temperature to 90°C, keep warm for 8h, then cool down.

[0089] The mother liquor was filtered and washed three times with water to remove residual dispersant. Filter the liquid, add methylal to submerge the resin layer, stir for 1 h, filter and dry, repeat 5 times. After filtering the methylal, add water to boil the balls, and finally raise the temperature to 100°C, distill and recover the remaining methylal in the chlorine balls, until the steamed gas has no methylal smell, filter the liquid, and dry at 85°C under reduced ...

Embodiment 2

[0102] (1) Suspension polymerization

[0103] Mix 225.3g styrene, 24.7g 63.3%wt divinylbenzene, 250.0g liquid paraffin and 2.5g benzoyl peroxide evenly, add 1000.0g 0.8%wt gelatin aqueous solution into a 3000mL three-port container with mechanical stirring and a thermometer in the flask. Start the mechanical stirring, slowly raise the temperature to 78°C, and keep it for 3 hours; then slowly raise the temperature to 88°C, and keep it for 3 hours; finally, slowly raise the temperature to 93°C, keep it for 7 hours, and then cool down.

[0104] The mother liquor was filtered and washed three times with water to remove residual dispersant. Filter the liquid, add methylal to cover the resin layer, stir for 45min, filter and dry, repeat 6 times. After filtering the methylal, add water to boil the balls, finally raise the temperature to 98°C, distill and recover the remaining methylal in the chlorine balls, until the evaporated gas has no methylal smell, filter the liquid, and dry ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of an adsorption material for blood perfusion. The preparation method comprises the following steps: preparing an oil phase and a water phase, by a suspension polymerization process, preparing a macroporous adsorption resin precursor with the particle size distribution being 0.315-0.8 mm from the the prepared oil phase and water phase, carrying out chloromethylation on the prepared macroporous adsorption resin precursor to prepare a chloromethylated macroporous adsorption resin precursor, carrying out post-crosslinking on the prepared chloromethylated macroporous adsorption resin precursor to prepare macroporous adsorption resin of which the residual chlorine content is less than or equal to 2%, and carrying out post-treatment on the prepared macroporous adsorption resin to prepare the surface functionalized macroporous adsorption resin with adsorption capacity for blood perfusion. According to the invention, recycling of residual chloromethyl ether after the chloromethylation reaction in the synthesis process of the macroporous adsorption resin for blood perfusion is realized, and remarkable economic benefits and environmental protection benefits are brought.

Description

technical field [0001] The invention belongs to the technical field of blood purification, and in particular relates to a preparation method of an adsorption material for blood perfusion. Background technique [0002] Hemoperfusion is a method of blood purification. By making the patient's blood flow through the perfusion device, it is in contact with the adsorption material in the perfusion device. With the help of adsorption, the purpose of removing or reducing harmful substances in the blood is achieved. Compared with conventional hemodialysis technology, hemoperfusion technology can protect the remaining liver and kidney functions of patients under the premise of ensuring the curative effect, and has strong adaptability and relatively low cost, so it has great development potential. In practical application, hemoperfusion technology can be used not only alone, but also in conjunction with hemodialysis technology. [0003] The core of hemoperfusion technology lies in the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/30A61M1/36C08F212/08C08F212/36C08J9/36C08J9/28C08L25/08
CPCB01J20/267A61M1/3679C08F212/08C08J9/36C08J9/28C08J2325/08C08F212/36
Inventor 梅昂张运潘群艳冯志军孙冰杰
Owner XIAN LANSHEN NEW MATERIAL TECHNOLOGY CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com