Bisphosphonate type self-setting composite bone graft and preparation method thereof

A bone graft, bisphosphonate technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problem of difficult to provide osteogenic elements, achieve good injectability, good plastic solidification performance, high mechanical the effect of strength

Active Publication Date: 2020-08-18
中鼎凯瑞科技成都有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] (3) The basic elements of bone formation are free calcium ions and free phosphate ions. Through the regulation of DNA, insoluble calcium salts such as hydroxyapatite are gradually formed to form bone tissue. Single bisphosphonates such as alendronate Act directly on osteoclasts, inhibit the rate-limiting steps in the biosynthesis pathway of cholesterol, and it is difficult to provide more osteogenic elements;

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Take 32.51g of alendronate sodium, dissolve it in 500ml of water, stir and dissolve it completely, add 5.55g of anhydrous calcium chloride, stir thoroughly for 2 hours, and let it stand for 12 hours; then centrifuge to remove the supernatant, wash with water for four weeks 26.5 g of alendronate calcium salt (CaR) was obtained after freeze-drying.

[0047] Take 10g of alendronate calcium salt (CaR), 10g of tricalcium silicate (CaSS1) and 20g of calcium sulfate hemihydrate (CaSS2) dried at 120°C, and 0.5g of hyaluronic acid for ball milling at a ball milling speed of 150r / m, ball milled for 6 hours and filtered through a 120-mesh sieve; 39.75 g of the compound was obtained.

[0048] Weigh 10g of the compound obtained, add 5ml of water, stir evenly, and then put the mud body into a polytetrafluoroethylene mold with a diameter of 6mm and 12mm for molding; take out the sample after 10 minutes,

[0049] After 2 hours and 24 hours, measure the compressive strength in an envi...

Embodiment 2

[0055] Take 32.51g of alendronate sodium, dissolve it in 500ml of water, stir and dissolve it completely, add 8.31g of calcium citrate, stir thoroughly for 2 hours, and let it stand for 12 hours; then centrifuge to remove the supernatant, and wash with water four times Freeze-drying yielded 27.1 g of alendronate calcium salt (CaR).

[0056] Take 15g of alendronate calcium salt (CaR), 10g of calcium citrate (CaSS1), 5g of calcium hydrogen phosphate (CaSS2), 20g of calcium sulfate hemihydrate (CaSS3), and 0.5g of hyaluronic acid that were dried at 120°C and mix them separately. Ball milling at a ball milling rate of 150 r / m, and after ball milling for 6 hours, filter through a 120-mesh sieve to obtain 49.25 g of the compound.

[0057] Weigh 20g of the obtained compound, add 11ml of water, stir evenly, and then put the slurry body into a polytetrafluoroethylene mold with a diameter of 6mm and 12mm for molding. The samples were taken out after 10 minutes, and the compressive stre...

Embodiment 3

[0062] Get 59.8g neridronic acid sodium salt, be dissolved in 1000ml water, stir etc. after dissolving completely, add 7.75g tricalcium silicate (C 3 S), fully stirred for 2 hours, and left for 12 hours; then centrifuged to remove the supernatant, washed with water for four times and freeze-dried to obtain 58.5g neridronic acid calcium salt (CaR).

[0063] Take 20g neridronic acid calcium salt (CaR), 15g dicalcium silicate (CaSS1), 10g calcium citrate (CaSS2), 20g calcium sulfate hemihydrate (CaSS3), 0.5g hyaluronic acid and mix Ball milling was carried out at a ball milling rate of 150 r / m, and after ball milling for 6 hours, it was filtered through a 120-mesh sieve; 63.80 g of the compound was obtained.

[0064] Weigh 20g of the obtained compound, add 10ml of water, stir evenly, and then put the slurry body into a polytetrafluoroethylene mold with a diameter of 6mm and 12mm for molding. The samples were taken out after 10 minutes, and the compressive strength was measured a...

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Abstract

The invention belongs to the field of bone repair materials, and particularly relates to a bisphosphonate type self-setting composite bone graft for osteoporosis repair and reconstruction and a preparation method thereof. The invention provides the bisphosphonate type self-setting composite bone graft which is a calcium bisphosphonate / self-setting calcium salt compound, the calcium bisphosphonate / self-setting calcium salt compound is composed of a solid phase part and a liquid phase part, and the solid-to-liquid ratio is 1: 0.3-1.0 g / ml, wherein the solid phase part comprises calcium bisphosphonate and a self-setting calcium salt, and the mass ratio of the calcium bisphosphonate to the self-setting calcium salt is 1: (1-6). The diphosphonate and the self-setting composite material are compounded for the first time to obtain the bone graft, and the self-setting composite bone graft has excellent injectability, proper setting time, slow diphosphonate release and excellent biological activity, and can be used for repairing, reconstructing and functional recovery of bone defects caused by osteoporosis and wounds.

Description

technical field [0001] The invention belongs to the field of bone repair materials, in particular to a bisphosphonate type self-solidifying composite bone graft for osteoporosis repair and reconstruction and a preparation method thereof. Background technique [0002] Osteoporosis (OP) is a systemic bone metabolic disease characterized by low bone mass and microarchitectural destruction of bone tissue, leading to increased bone fragility and susceptibility to fracture. All ages can be onset, divided into two types of primary and secondary. Primary osteoporosis refers to other diseases that do not cause the disease; secondary osteoporosis refers to the reduction of bone tissue due to various systemic or endocrine and metabolic diseases. Vertebral compression fractures often occur unknowingly, and can also be induced by coughing, sneezing, and minor trauma. Within a few weeks of fresh vertebral fractures, local pain occurs, and the signs appear to be percussion pain. Those w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/54A61L27/58
CPCA61L27/427A61L27/54A61L27/58A61L2300/112A61L2300/604A61L2300/40A61L2430/02
Inventor 严永刚邓光进
Owner 中鼎凯瑞科技成都有限公司
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