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Bisphosphonate type self-solidifying composite bone graft and preparation method thereof

A bone graft, bisphosphonate technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problem of difficult to provide osteogenic elements, and achieve good injectability, good plastic and solidification performance, high mechanical the effect of strength

Active Publication Date: 2022-06-24
中鼎凯瑞科技成都有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] (3) The basic elements of bone formation are free calcium ions and free phosphate ions. Through the regulation of DNA, insoluble calcium salts such as hydroxyapatite are gradually formed to form bone tissue. Single bisphosphonates such as alendronate Act directly on osteoclasts, inhibit the rate-limiting steps in the biosynthesis pathway of cholesterol, and it is difficult to provide more osteogenic elements;

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Take 32.51g of alendronate sodium, dissolve it in 500ml of water, and after stirring, add 5.55g of anhydrous calcium chloride, stir well for 2 hours, and leave it for 12 hours; then remove the supernatant by centrifugation, and wash the four 26.5 g of calcium alendronate (CaR) was obtained by freeze-drying.

[0047] Take 10 g of calcium alendronate (CaR), 10 g of tricalcium silicate (CaSS1) dried at 120°C, 20 g of calcium sulfate hemihydrate (CaSS2), and 0.5 g of hyaluronic acid, respectively, for ball milling, and the ball milling rate is 150 r / m, ball-milled for 6 hours and filtered through a 120-mesh sieve; 39.75 g of a complex was obtained.

[0048] Weigh 10g of the obtained compound, add 5ml of water, stir evenly, and then put the slurry into a 6mm diameter and 12mm diameter polytetrafluoroethylene mold to shape; after 10 minutes, take out the sample,

[0049] After 2 hours and 24 hours, the compressive strength was measured in an environment of 25° C. and a humi...

Embodiment 2

[0055] Take 32.51g of alendronate sodium, dissolve it in 500ml of water, and after stirring, add 8.31g of calcium citrate, stir well for 2 hours, and leave it for 12 hours; then remove the supernatant by centrifugation and wash it with water for four times. Freeze-dried to obtain 27.1 g of alendronate calcium salt (CaR).

[0056] Take 15g alendronate calcium salt (CaR), 10g calcium citrate (CaSS1) dried at 120℃, 5g calcium hydrogen phosphate (CaSS2), 20g calcium sulfate hemihydrate (CaSS3), 0.5g hyaluronic acid and mix them respectively. Ball milling with a ball milling rate of 150 r / m, and filtering through a 120-mesh sieve after ball milling for 6 hours; 49.25 g of a compound was obtained.

[0057] Weigh 20 g of the obtained compound, add 11 ml of water, stir evenly, and then put the mud body into a polytetrafluoroethylene mold with a diameter of 6 mm and a diameter of 12 mm for molding. The samples were taken out after 10 minutes, and the compressive strength was measured ...

Embodiment 3

[0062] Take 59.8g of neridronate sodium salt, dissolve it in 1000ml of water, stir and wait for it to dissolve completely, add 7.75g of tricalcium silicate (C 3 S), fully stirred for 2 hours, and placed for 12 hours; then the supernatant was removed by centrifugation, washed with water four times by centrifugation, and freeze-dried to obtain 58.5 g of calcium neridronate (CaR).

[0063] Mix 20g calcium neridronate (CaR), 15g dicalcium silicate (CaSS1) dried at 120°C, 10g calcium citrate (CaSS2), 20g calcium sulfate hemihydrate (CaSS3), and 0.5g hyaluronic acid respectively. Carry out ball milling with a ball milling rate of 150 r / m, and filter through a 120-mesh sieve after ball milling for 6 hours; 63.80 g of a compound is obtained.

[0064] Weigh 20g of the obtained compound, add 10ml of water, stir evenly, and then put the mud body into a polytetrafluoroethylene mold with a diameter of 6mm and 12mm for molding. The samples were taken out after 10 minutes, and the compressi...

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Abstract

The invention belongs to the field of bone repair materials, in particular to a bisphosphonate type self-solidifying composite bone graft for osteoporosis repair and reconstruction and a preparation method thereof. The invention provides a bisphosphonate type self-solidifying composite bone graft, the composite bone graft is a bisphosphonate calcium salt / self-solidifying calcium salt complex, and the bisphosphonate calcium salt / self-solidifying calcium salt complex The product is composed of a solid phase part and a liquid phase part, and the solid-liquid ratio is 1:0.3~1.0g / ml; among them, the solid phase part includes bisphosphonic acid calcium salt and self-solidifying calcium salt, and the mass ratio of each raw material is: bisphosphine Acid calcium salt: self-solidifying calcium salt = 1:1~6. The present invention combines bisphosphonate and self-solidifying composite material for the first time to obtain a bone graft, and the self-solidifying composite bone graft has excellent injectability, suitable setting time, slow release of bisphosphonate and excellent biological It can be used for the repair, reconstruction and functional recovery of bone defects caused by osteoporosis and trauma.

Description

technical field [0001] The invention belongs to the field of bone repair materials, in particular to a bisphosphonate-type self-solidifying composite bone graft used for osteoporosis repair and reconstruction and a preparation method thereof. Background technique [0002] Osteoporosis (OP) is a systemic metabolic bone disease characterized by low bone mass and microstructural destruction of bone tissue, leading to increased bone fragility and susceptibility to fractures. The disease can occur at all ages and is divided into two categories: primary and secondary. Primary osteoporosis refers to the absence of other diseases that cause the disease; secondary osteoporosis refers to the reduction of bone tissue due to various systemic or endocrine and metabolic diseases. Vertebral body compression fractures often occur unconsciously, and vertebral body fractures can also be induced by coughing, sneezing, and minor trauma. Within weeks of fresh vertebral fractures, localized pai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/54A61L27/58
CPCA61L27/427A61L27/54A61L27/58A61L2300/112A61L2300/604A61L2300/40A61L2430/02
Inventor 严永刚邓光进
Owner 中鼎凯瑞科技成都有限公司
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