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High-moisture-absorption wound dressing and preparation method therefor

A highly hygroscopic and wound technology, applied in the field of synthetic polymer biomaterials, can solve the problem of not absorbing wound exudate, etc., and achieve the effects of large specific surface area, enhanced material strength, and low density

Active Publication Date: 2020-09-04
JIANGSU YENSSEN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, in the field of wound dressings, PDMS-based dressings will also have great feasibility and potential; however, the surface of traditional covalently cross-linked PDMS materials has strong hydrophobicity, does not have the ability to absorb wound exudate, and is difficult to Apply directly in wound dressings

Method used

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  • High-moisture-absorption wound dressing and preparation method therefor
  • High-moisture-absorption wound dressing and preparation method therefor
  • High-moisture-absorption wound dressing and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Silica airgel (SiO 2 ) preparation

[0035] Calculated in parts by mass, put 9 parts of TEOS, 3 parts of water and 18 parts of ethanol in the reaction kettle, add hydrochloric acid solution to adjust the pH=2, heat to 40°C and hydrolyze for 3 hours, then add ammonia water dropwise to adjust the pH value to 9 , the gel began to form during the process; the obtained wet gel was placed in 20 parts of aging solution (V(TEOS):V(EtOH)=1:10) and aged at 50°C for 24h and then aged at 600°C under nitrogen atmosphere Calcined for 120min to dry to obtain SiO 2 airgel.

[0036] The resulting SiO 2 Airgel apparent density is 98mg / cm 3 , the specific surface area is 823m 2 / g.

[0037] The resulting SiO 2 The airgel was ground into particles with an average particle size of 75 μm in a high-energy ball mill for use.

[0038] (2) Amino silicone oil (PDMS-amino 2 ) preparation

[0039] 99.86g octamethylcyclotetrasiloxane (D 4 ), 33.72g of 1,3-bis(3-aminopropyl)-1,1,3,3-te...

Embodiment 2

[0047] Steps (1) to (3) are the same as in Example 1.

[0048] (4) PDMS-hybrid-SiO 2 (2%) The synthetic synthetic method of dressing material is identical with embodiment 1, and each raw material feeding quality is: 0.25gSiO 2 Airgel, 11.12g PDMS-vinyl 2 .

Embodiment 3

[0050] Steps (1) to (3) are the same as in Example 1.

[0051] (4) PDMS-hybrid-SiO 2 (4%) The synthetic synthetic method of dressing material is identical with embodiment 1, and each raw material feeding quality is: 0.48gSiO 2 Airgel, 11.05g PDMS-vinyl 2 .

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PUM

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Abstract

The invention discloses a high-moisture-absorption wound dressing and a preparation method therefor. The method comprises the steps of preparing SiO2 aerogel, carrying out pulverizing, and carrying out mixed addition polymerization with free-radical polymerization monomers in a manner that the SiO2 aerogel can be in series connection with a polymer molecular chain so as to act a chemical crosslinking action. The free-radical polymerization monomers comprise 20-40 parts of vinyl-terminated polysiloxane, 2-10 parts of mono-functionality reaction monomers and 1-5 parts of tri-functionality reaction monomers; and the product is an elastomer with a three-dimensional cross-linked structure, has good diffusate absorbability in case of being applied to dressing materials and has potential application in moist dressings.

Description

technical field [0001] The invention belongs to the technical field of synthetic macromolecular biomaterials, and in particular relates to a highly hygroscopic polysiloxane elastomer skin wound dressing and a preparation method thereof. [0002] technical background [0003] Winter put forward the theory of "wet healing" in 1974: a moist wound environment can greatly increase the biological activity of various cells, enzymes and growth factors, thereby promoting the growth of granulation tissue and contributing to wound healing. Based on this theory, Turner proposed in 1982 that an ideal dressing should have the following characteristics: keep the wound moist, have a certain absorption capacity to remove excess exudate from the wound, allow gas exchange, heat insulation, isolate bacteria, and not affect the patient's freedom action etc. In recent years, many occlusive dressings with various structures and functions and conforming to the "wet healing" theory have been release...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/24A61L15/42A61L15/60C08F283/00C08F220/06C08F220/20C08F220/34C08F230/08C08F212/34C08F2/44C08K3/36C08G18/61C08G18/67
CPCA61L15/24A61L15/42A61L15/60A61L15/425C08F283/008C08F2/44C08K3/36C08G18/61C08G18/672C08L51/085C08F220/06C08F220/20C08F220/34C08F230/085C08F212/34
Inventor 张玉花
Owner JIANGSU YENSSEN BIOTECH CO LTD