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Acoustic processing for cell and gene therapy

A cell, acoustic device technology, applied in the field of acoustic processing for cell therapy and gene therapy, can solve the problems of high cost, increase overall cost, etc., achieve the effect of minimum reduction, increase overall process efficiency, and minimum transfer steps

Pending Publication Date: 2020-09-04
FLODESIGN SONICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many technologies and methods are used to produce therapeutic products, each of which tends to be standalone, open or non-sterile and expensive
For example, the method may be implemented by several highly skilled personnel on specialized equipment, adding to the overall cost

Method used

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  • Acoustic processing for cell and gene therapy
  • Acoustic processing for cell and gene therapy
  • Acoustic processing for cell and gene therapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0180] Figure 14 – Example - one unit for multiple operations

[0181] 14A – ACW at edge effects for density-based separations – extract RBC 160, granulocyte 162, ficoll 164, Leave PBMC 166 and plasma 168

[0182] 14B – Connect the ACW to the wash assembly

[0183] No option – process all PBMC

[0184] 14C – connect to bioreactor and activate, wash, transfect, amplify

[0185] -

[0186] Figure 15 - Example - multiple units in series

[0187] 15A – Aspirate and discard non-PBMC, aspirate and collect PBMC

[0188] 15B – Transfer to concentration and washing unit

[0189] 15C – transfer to expansion bed for affinity selection of T cells

[0190] 15D – Transfer to bioreactor unit for activation and enhancement

[0191] 15E – Transfer to larger bioreactor unit for expansion

[0192] -

[0193] The methods, systems and apparatus discussed above are examples. Various configurations may omit, substitute, or add various procedures or components as appropriate. ...

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Abstract

A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.

Description

[0001] Cross References to Related Applications [0002] This application is a continuation-in-part of U.S. Patent Application Serial No. 16 / 124,184, filed September 6, 2018, which is a part of U.S. Patent Application Serial No. 15 / 942,427, filed March 30, 2018 Continuation of, and claiming priority to, provisional application 62 / 554,569, filed September 6, 2017, and is a continuation-in-part of U.S. Patent Application Serial No. 15 / 586,116, filed May 3, 2017, the U.S. Patent application claiming priority to provisional application U.S. Patent Application Serial No. 62 / 479,309, filed March 30, 2017, and claiming priority to provisional application U.S. Patent Application Serial No. 62 / 374,910, filed August 15, 2016 , and claims priority to provisional application 62 / 359,182, filed July 6, 2016, and claims priority to provisional application 62 / 330,947, filed May 3, 2016. This application is a continuation-in-part of U.S. Patent Application Serial No. 16 / 010,296, filed June 15,...

Claims

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Application Information

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IPC IPC(8): C12M1/00C12N5/078C12N13/00B01D21/28B02C19/00B02C19/18
CPCB01D21/28C12N13/00B01D15/1807C12M47/10C12M33/22
Inventor B·利普肯斯R·托斯通伊斯W·M·小普雷茨B·罗斯-约翰斯鲁德K·奇塔莱T·J·肯尼迪三世B·杜特拉B·麦卡锡J·萨罗伊奥
Owner FLODESIGN SONICS
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