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Plasma metabolism marker related to diagnosis of tourette syndrome (TS) of children and application thereof

A technology of multiple tic syndrome and metabolic markers, applied in the field of metabolomics, to achieve the effects of relieving pain, facilitating diagnosis, and improving sensitivity and specificity

Active Publication Date: 2020-09-22
NANJING HOSPITAL OF T C M
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, there has been no report on the metabolomic characteristics of TS so far. Therefore, this study screened out the plasma differences between TS patients and healthy children based on non-targeted metabolomics, and further analyzed the differential compounds based on targeted metabolomics technology. For verification, the obtained differential metabolites are applied to the clinical diagnosis of TS, and the detection of plasma is non-invasive and non-invasive. Therefore, screening early diagnostic markers for TS in children from plasma can be accurately and conveniently used for clinical diagnosis. Provide evidence for doctors to formulate early diagnosis and intervention plans

Method used

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  • Plasma metabolism marker related to diagnosis of tourette syndrome (TS) of children and application thereof
  • Plasma metabolism marker related to diagnosis of tourette syndrome (TS) of children and application thereof
  • Plasma metabolism marker related to diagnosis of tourette syndrome (TS) of children and application thereof

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Embodiment 1

[0039] 1. Test materials: chromatographic grade acetonitrile (Merck), methanol (TEDIA); ammonium acetate (Sigma); standard L-glutamic acid hydrochloride, D-ornithine hydrochloride, L-ornithine hydrochloride Salt, D-pipercolic acid, D-proline, L-arginine, L-homoproline, L-carnitine (purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.); AB Triple TOF 5600 mass spectrometer (purchased from ABSCIEX, Framingham, MA, USA); Agilent 1290 Infinity LC ultra-high pressure liquid chromatograph (purchased from Agilent Technologies, Santa-Clara, California, USA); Agilent 6460 Triplequadrupole mass spectrometer (purchased from Agilent Technologies, Santa -Clara, California, USA); low-temperature high-speed centrifuge (Eppendorf5430R); chromatographic column: ACQUITY UPLC HSS T3 1.8μm, 2.1×100mm column (Waters); Agilent ZORBAX Hilic Plus 1.8μm, 50×2.1mm (Agilent, USA) .

[0040] 2. Sample collection and sample data collation:

[0041] The present invention uses a total of 49 ca...

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Abstract

The invention discloses a plasma metabolism marker related to diagnosis of tourette syndrome (TS) of children and an application thereof. The marker is L-arginine and D-piperidine acid. The marker isused for diagnosing the attack risk of TS of children from the perspective of metabolites, the result is accurate, objective and reliable, the TS group and the normal group can be well distinguished,the TS occurrence risk can be accurately and sensitively evaluated, only a blood sample needs to be provided, other tissue samples are not needed, the possibility and feasibility of clinical application are greatly improved, and a guidance basis is provided for a clinician to make an early diagnosis and intervention scheme.

Description

technical field [0001] The present invention relates to the field of metabolomics and medicine, in particular to a plasma metabolic marker related to the diagnosis of children's tic syndrome and its application. Background technique [0002] Tourette syndrome (Tourette syndrome, TS), also known as Tourette syndrome, is a chronic neuropsychiatric disorder with onset in childhood and can last until adolescence. It is characterized by motor tics and / or vocal tics in one or more parts of the body. Common motor tics can be manifested as eye blinking, eyebrow raising, grinning, shrugging, etc. Vocal tics such as throat humming, throat clearing, Screams, foul language, etc. In addition, children often have comorbidities such as attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), autism spectrum disorder (ASD), oppositional defiant disorder (ODD) and other disruptive behaviors. TS was once considered a rare disease, but the latest epidemiological ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/86
CPCG01N30/02G01N30/06G01N30/8675
Inventor 隆红艳席乐迎张亚杰周芙琼朱维娜阮杰马春华黄亚若
Owner NANJING HOSPITAL OF T C M
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