Application of a plasma metabolic marker related to the diagnosis of tic syndrome in children in the preparation of a diagnostic kit for tic syndrome in children

A technology of multiple tics and metabolic markers, applied in the field of metabolomics, to achieve the effect of improving possibility and feasibility, improving sensitivity and specificity, and simple operation

Active Publication Date: 2021-07-09
NANJING HOSPITAL OF T C M
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  • Abstract
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Problems solved by technology

[0007] However, there has been no report on the metabolomic characteristics of TS so far. Therefore, this study screened out the plasma differences between TS patients and healthy children based on non-targeted metabolomics, and further analyzed the differential compounds based on targeted metabolomics technology. For verification, the obtained differential metabolites are applied to the clinical diagnosis of TS, and the detection of plasma is non-invasive and non-invasive. Therefore, screening early diagnostic markers for TS in children from plasma can be accurately and conveniently used for clinical diagnosis. Provide evidence for doctors to formulate early diagnosis and intervention plans

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  • Application of a plasma metabolic marker related to the diagnosis of tic syndrome in children in the preparation of a diagnostic kit for tic syndrome in children
  • Application of a plasma metabolic marker related to the diagnosis of tic syndrome in children in the preparation of a diagnostic kit for tic syndrome in children
  • Application of a plasma metabolic marker related to the diagnosis of tic syndrome in children in the preparation of a diagnostic kit for tic syndrome in children

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Embodiment 1

[0039] 1. Test materials: chromatographic grade acetonitrile (Merck), methanol (TEDIA); ammonium acetate (Sigma); standard L-glutamic acid hydrochloride, D-ornithine hydrochloride, L-ornithine hydrochloride Salt, D-pipercolic acid, D-proline, L-arginine, L-homoproline, L-carnitine (purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.); AB Triple TOF 5600 mass spectrometer (purchased from ABSCIEX, Framingham, MA, USA); Agilent 1290 Infinity LC ultra-high pressure liquid chromatograph (purchased from Agilent Technologies, Santa-Clara, California, USA); Agilent 6460 Triplequadrupole mass spectrometer (purchased from Agilent Technologies, Santa -Clara, California, USA); low-temperature high-speed centrifuge (Eppendorf5430R); chromatographic column: ACQUITY UPLC HSS T3 1.8μm, 2.1×100mm column (Waters); Agilent ZORBAX Hilic Plus 1.8μm, 50×2.1mm (Aglient, USA) .

[0040] 2. Sample collection and sample data collation:

[0041] The present invention uses a total of 49 ca...

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Abstract

The invention discloses a blood plasma metabolic marker related to the diagnosis of Tourette syndrome (TS) in children and its application. The markers are L-arginine and D-pipericolic acid. The markers of the present invention can diagnose the risk of TS in children from the perspective of metabolites, and the results are accurate, objective and reliable, can well distinguish the TS group from the normal group, can accurately and sensitively evaluate the risk of TS, and only need to provide blood samples It can be carried out without other tissue samples, greatly improving the possibility and feasibility of clinical application, and providing guidance for clinicians to formulate early diagnosis and intervention plans.

Description

technical field [0001] The present invention relates to the field of metabolomics and medicine, in particular to a plasma metabolic marker related to the diagnosis of children's tic syndrome and its application. Background technique [0002] Tourette syndrome (Tourette syndrome, TS), also known as Tourette syndrome, is a chronic neuropsychiatric disorder with onset in childhood and can last until adolescence. It is characterized by motor tics and / or vocal tics in one or more parts of the body. Common motor tics can be manifested as eye blinking, eyebrow raising, grinning, shrugging, etc. Vocal tics such as throat humming, throat clearing, Screams, foul language, etc. In addition, children often have comorbidities such as attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), autism spectrum disorder (ASD), oppositional defiant disorder (ODD) and other disruptive behaviors. TS was once considered a rare disease, but the latest epidemiological ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/86
CPCG01N30/02G01N30/06G01N30/8675
Inventor 隆红艳席乐迎张亚杰周芙琼朱维娜阮杰马春华黄亚若
Owner NANJING HOSPITAL OF T C M
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