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Intraocular lens coating with excellent biological antifouling performance and preparation method thereof

A technology for intraocular lenses and coatings, applied in coatings, prostheses, tissue regeneration, etc., to achieve the effects of easy industrialized large-area treatment, good hydrophilic and anti-fouling properties, and improved biocompatibility

Active Publication Date: 2020-10-02
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the above-mentioned deficiencies in the prior art, the present invention provides an intraocular lens coating with excellent biological antifouling performance and a preparation method thereof, which adjusts the surface characteristics of the intraocular lens by combining a transition layer and a functional layer, and improves the surface properties of the material. Hydrophilic and biological anti-fouling properties, improve the biocompatibility of the intraocular lens, effectively prevent or reduce the adhesion of cells, proteins and bacteria on the surface of the lens and the occurrence of inflammatory reactions, thereby reducing the probability of secondary cataracts

Method used

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  • Intraocular lens coating with excellent biological antifouling performance and preparation method thereof
  • Intraocular lens coating with excellent biological antifouling performance and preparation method thereof
  • Intraocular lens coating with excellent biological antifouling performance and preparation method thereof

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Embodiment 1

[0029] A method for preparing an intraocular lens coating with excellent biological antifouling performance, comprising the following steps:

[0030] (1) The rigid polymethyl methacrylate intraocular lens material is subjected to low-temperature plasma surface treatment at 50V for 40s, and then the rigid polymethyl methacrylate intraocular lens material is dipped into the epoxy resin solution for 15s , dried at a temperature of 50°C to obtain a transition layer;

[0031] (2) Prepare a polyvinyl alcohol solution with a concentration of 5 mg / ml, then place the transition layer obtained in step (1) into the polyvinyl alcohol solution and immerse it for 5 minutes, and dry it at 50°C to obtain an intraocular lens with excellent biological antifouling properties coating.

Embodiment 2

[0033] A method for preparing an intraocular lens coating with excellent biological antifouling performance, comprising the following steps:

[0034] (1) The rigid polymethyl methacrylate intraocular lens material was subjected to low-temperature plasma surface treatment at a voltage of 70V for 30s, and then the rigid polymethyl methacrylate intraocular lens material was dip-coated in an epoxy resin solution for 20s. Dry at a temperature of ℃ to obtain a transition layer;

[0035] (2) Prepare a polyoxyethylene solution with a concentration of 10mg / ml, then place the transition layer obtained in step (1) into the polyoxyethylene solution and immerse it for 5 minutes, and dry it at a temperature of 50°C to obtain an intraocular lens with excellent biological antifouling properties coating.

Embodiment 3

[0037] A method for preparing an intraocular lens coating with excellent biological antifouling performance, comprising the following steps:

[0038] (1) The poly(hydroxyethyl methacrylate) intraocular lens material was subjected to low-temperature plasma surface treatment at 80V for 90s, and then the poly(hydroxyethyl methacrylate) intraocular lens material was dip-coated in the epoxy resin solution for 10s. Dry at a temperature of ℃ to obtain a transition layer;

[0039] (2) Prepare a poly-2-methacryloyloxyethylphosphorylcholine solution with a concentration of 8 mg / ml, and then place the transition layer obtained in step (1) into the poly-2-methacryloyloxyethylphosphorylcholine solution Immerse for 15s and dry at 30°C to obtain an intraocular lens coating with excellent biological antifouling performance.

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Abstract

The invention discloses a preparation method of an intraocular lens coating with excellent biological antifouling performance. The preparation method includes the following steps that low-temperatureplasma surface treatment is performed on the surface of an intraocular lens material, then an adhesive is coated on the surface of the intraocular lens material, and drying is carried out to obtain atransition layer; and a functional layer coating solution with a concentration of 0.1-30wt% is prepared with a hydrophilic polymer and then coated on the transition layer, and drying is carried out toobtain the intraocular lens coating with excellent biological antifouling performance. The invention further includes the intraocular lens coating with excellent biological antifouling performance prepared by the preparation method. The surface characteristics of an intraocular lens are adjusted through the method of combining the transition layer and the functional layer, the hydrophilicity andbiofouling resistance of the material surface are improved, the biocompatibility of the intraocular lens is improved, the occurrence of adhesion of cells, proteins and bacteria on the surface of the lens and inflammatory reactions is effectively prevented or reduced, and therefore the probability of secondary cataract is reduced.

Description

technical field [0001] The invention belongs to the technical field of ophthalmic medical implant materials, and in particular relates to an intraocular lens coating with excellent biological antifouling performance and a preparation method thereof. Background technique [0002] According to the report of the World Health Organization, cataract is the world's first blinding eye disease. It is due to the cloudiness of the lens, and the light cannot pass through the cloudy lens and fall on the retina, resulting in vision loss. Clinical treatment is mainly carried out by means of surgery. The treatment of cataracts, from ancient Indian gold needle surgery to extracapsular cataract extraction, intracapsular cataract extraction, to the current phacoemulsification cataract surgery and femtosecond laser cataract surgery, has proved that surgery is the only scientific treatment for cataract method. At present, more advanced cataract surgery methods mainly include phacoemulsificati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/50
CPCA61L27/34A61L27/50A61L2400/18A61L2420/02A61L2430/16C08L29/04C08L5/08C08L71/02
Inventor 王云兵兰小蓉何周坤雷洋
Owner SICHUAN UNIV
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