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A kind of intraocular lens coating with excellent biological antifouling performance and preparation method thereof

An intraocular lens and coating technology, which is applied in the directions of coating, prosthesis, drug delivery, etc., to achieve the effects of improving hydrophilicity and biological antifouling, low cost, and reducing the probability of secondary cataracts

Active Publication Date: 2021-07-20
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the above-mentioned deficiencies in the prior art, the present invention provides an intraocular lens coating with excellent biological antifouling performance and a preparation method thereof, which adjusts the surface characteristics of the intraocular lens by combining a transition layer and a functional layer, and improves the surface properties of the material. Hydrophilic and biological anti-fouling properties, improve the biocompatibility of the intraocular lens, effectively prevent or reduce the adhesion of cells, proteins and bacteria on the surface of the lens and the occurrence of inflammatory reactions, thereby reducing the probability of secondary cataracts

Method used

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  • A kind of intraocular lens coating with excellent biological antifouling performance and preparation method thereof
  • A kind of intraocular lens coating with excellent biological antifouling performance and preparation method thereof
  • A kind of intraocular lens coating with excellent biological antifouling performance and preparation method thereof

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Embodiment 1

[0029] A method for preparing an intraocular lens coating with excellent biological antifouling performance, comprising the following steps:

[0030] (1) The rigid polymethyl methacrylate intraocular lens material is subjected to low-temperature plasma surface treatment at 50V for 40s, and then the rigid polymethyl methacrylate intraocular lens material is dipped into the epoxy resin solution for 15s , dried at a temperature of 50°C to obtain a transition layer;

[0031] (2) Prepare a polyvinyl alcohol solution with a concentration of 5 mg / ml, then place the transition layer obtained in step (1) into the polyvinyl alcohol solution and immerse it for 5 minutes, and dry it at 50°C to obtain an intraocular lens with excellent biological antifouling properties coating.

Embodiment 2

[0033] A method for preparing an intraocular lens coating with excellent biological antifouling performance, comprising the following steps:

[0034] (1) The rigid polymethyl methacrylate intraocular lens material was subjected to low-temperature plasma surface treatment at a voltage of 70V for 30s, and then the rigid polymethyl methacrylate intraocular lens material was dip-coated in an epoxy resin solution for 20s. Dry at a temperature of ℃ to obtain a transition layer;

[0035] (2) Prepare a polyoxyethylene solution with a concentration of 10mg / ml, then place the transition layer obtained in step (1) into the polyoxyethylene solution and immerse it for 5 minutes, and dry it at a temperature of 50°C to obtain an intraocular lens with excellent biological antifouling properties coating.

Embodiment 3

[0037] A method for preparing an intraocular lens coating with excellent biological antifouling performance, comprising the following steps:

[0038] (1) The poly(hydroxyethyl methacrylate) intraocular lens material was subjected to low-temperature plasma surface treatment at 80V for 90s, and then the poly(hydroxyethyl methacrylate) intraocular lens material was dip-coated in the epoxy resin solution for 10s. Dry at a temperature of ℃ to obtain a transition layer;

[0039] (2) Prepare a poly-2-methacryloyloxyethylphosphorylcholine solution with a concentration of 8 mg / ml, and then place the transition layer obtained in step (1) into the poly-2-methacryloyloxyethylphosphorylcholine solution Immerse for 15s and dry at 30°C to obtain an intraocular lens coating with excellent biological antifouling performance.

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Abstract

The invention discloses a preparation method of an intraocular lens coating with excellent biological antifouling performance. The preparation method comprises the following steps: performing low-temperature plasma surface treatment on the surface of the intraocular lens material, and then coating the surface of the intraocular lens material with an adhesive, and drying the to obtain a transition layer; use a hydrophilic polymer to configure a functional layer coating solution with a concentration of 0.1 to 30 wt%, and then coat the transition layer and dry to obtain an intraocular lens coating with excellent biological antifouling performance. The present invention also includes the intraocular lens coating with excellent biological antifouling performance prepared by the above method. The present invention adjusts the surface characteristics of the intraocular lens through the method of combining the transition layer and the functional layer, improves the hydrophilicity and biological antifouling of the material surface, improves the biocompatibility of the intraocular lens, and effectively prevents or reduces cells, proteins and Bacteria, etc. adhere to the surface of the lens and the occurrence of inflammatory reactions, thereby reducing the probability of secondary cataracts.

Description

technical field [0001] The invention belongs to the technical field of ophthalmic medical implant materials, and in particular relates to an intraocular lens coating with excellent biological antifouling performance and a preparation method thereof. Background technique [0002] According to the report of the World Health Organization, cataract is the world's first blinding eye disease. It is due to the cloudiness of the lens, and the light cannot pass through the cloudy lens and fall on the retina, resulting in vision loss. Clinical treatment is mainly carried out by means of surgery. The treatment of cataracts, from ancient Indian gold needle surgery to extracapsular cataract extraction, intracapsular cataract extraction, to the current phacoemulsification cataract surgery and femtosecond laser cataract surgery, has proved that surgery is the only scientific treatment for cataract method. At present, more advanced cataract surgery methods mainly include phacoemulsificati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/50
CPCA61L27/34A61L27/50A61L2400/18A61L2420/02A61L2430/16C08L29/04C08L5/08C08L71/02
Inventor 王云兵兰小蓉何周坤雷洋
Owner SICHUAN UNIV