Traditional Chinese medicine composition for regulating intestinal flora and application thereof

A technology of intestinal flora and composition, applied in the directions of drug combination, medical raw materials derived from arthropods, and pharmaceutical formulations, etc., can solve the problems of ineffective clinical research on intestinal flora and difficulties in carrying out fecal bacteria transplantation treatment, etc. Improve vascular cognitive dysfunction, simple formula, wide-ranging effect

Inactive Publication Date: 2020-10-09
JIANGSU PROVINCIAL HOSPITAL OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, there is no effective clinical research on the treatment of intestinal flora transplantation for cognitive impairment.
[0029] In addition, the current fecal microbiota transplantation treatment is difficult to carry out, including the selection of fecal donors, the preparation of fecal microbiota liquid, and the preparation of recipients before transplantation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Example 1 Screening of effective drugs for regulating intestinal flora of traditional Chinese medicine and observation of curative effect in rat cerebral ischemia-hypoxia model.

[0065] The impairment of cognitive function is one of the more obvious clinical manifestations of patients with cerebral ischemia and hypoxia, especially in patients with vascular cognitive impairment after cerebral ischemia and hypoxia. Therefore, the recovery of memory and learning ability has always been the goal of clinical treatment . In this experiment, rats with bilateral common carotid artery ligation were used as animal models of cerebral ischemia and hypoxia, and water maze experiments were used to detect silkworm excrement, Renzhonghuang, Wulingzhi, Mochiyuesha, Yemingsha, Renzhongbai, and Cordyceps militaris respectively. , Therapeutic effect of stiff silkworm, snake slough, Yu Yuliang, sea pumice on learning and memory impairment in rats with cerebral ischemia and hypoxia.

[006...

Embodiment 2

[0082] Example 2 Screening of effective drugs for regulating intestinal flora of traditional Chinese medicine and observation of curative effect on Aβ25-35 to prepare a mouse model of senile dementia.

[0083] According to the theory of traditional Chinese medicine, Aβ has the characteristics of corrupting the body and damaging the brain, and belongs to the category of "endogenous turbidity" produced by the human body. The dysfunction of peripheral clearance of Aβ in the liver leads to the accumulation of Aβ in the brain, which is consistent with the pathogenesis of "disease of the spleen" leading to "toxic damage to the brain collaterals" in the "sluggish syndrome" of traditional Chinese medicine. We speculate that TCM gut microbiota-modulating drugs can improve cognitive function and pathology in APP / PS1 mice, and can reduce Aβ levels in the brain.

[0084] (1) Experimental method:

[0085] Experimental grouping and administration: Silkworm excrement 15g, Renzhonghuang 9g, ...

Embodiment 3

[0094] Example 3 Screening of effective components of drugs that may regulate the intestinal flora of traditional Chinese medicine.

[0095] Select AP / PS-1 double transgenic mice, convert the oral dosage of effective Chinese medicine components according to the usual dosage of traditional Chinese medicine in clinical application, and randomly divide the double transgenic mice into high-dose group, middle-dose group, low-dose group and control group , orally administered for 3 months. After the medication was finished, the mice were trained to locate and cruise by using the Morris water maze test method, training 4 times a day, with an interval of 1 hour each time, for 4 days, and then performed a locate and navigate test and a space exploration test to detect the learning and memory of the mice. Ability to acquire and maintain memory of the spatial location of the platform. Studies have shown that the drugs that can effectively reduce the distance time for mice to reach the p...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for regulating intestinal flora, which is characterized by comprising the following components in parts by weight: 10-15 parts of silkworm excrement, 6-9 parts of human middle yellow, 4.5-9 parts of trogopterus dung and 3-6 parts of tamarind sand. The invention further provides an application of the traditional Chinese medicine composition in preparation of medicines for improving vascular cognitive disorder related diseases. The vascular cognitive disorder related diseases are any one of non-dementia vascular cognitive disorder, vascular cognitive disorder complicated with sleep disorder, adrenal leukodystrophy, acute ischemic hypoxic encephalopathy, intestinal flora translocation encephalopathy, acute ischemic stroke andacute retinal central artery occlusion. The traditional Chinese medicine composition is simple in formula and wide in source, can effectively improve vascular cognitive impairment, and has a certain intervention effect on various accompanying risk factors such as hypertension, hypercholesterolemia, diabetes, metabolic syndrome and atherosclerosis.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for improving vascular cognitive impairment. Background technique [0002] Vascular cognitive impairment is an acquired syndrome of hypercognitive impairment and cognitive impairment, which is caused by risk factors associated with cerebrovascular disease, overt or not overt cerebrovascular disease, ranging from mild cognitive impairment to dementia a type of syndrome. Among them, cerebrovascular risk factors include hypertension, diabetes, and hyperlipidemia. Vascular cognitive impairment includes non-dementia vascular cognitive impairment, vascular dementia and senile dementia with vascular factors, that is, mixed dementia. Non-dementia vascular cognitive impairment refers to early vascular cognitive impairment that has not yet reached the dementia criteria. The study found that, so far, the only preventable form of cogniti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61K36/71A61K36/65A61K36/804A61P1/00A61P25/28A61P25/20A61P25/00A61P9/10A61P27/02A61P9/12A61P3/06A61P3/10A61P3/00A61K35/64A61K35/24A61K35/22A61K33/06
CPCA61K33/06A61K35/22A61K35/24A61K35/64A61K36/068A61K36/21A61K36/28A61K36/346A61K36/46A61K36/481A61K36/484A61K36/539A61K36/54A61K36/605A61K36/65A61K36/708A61K36/71A61K36/804A61P1/00A61P3/00A61P3/06A61P3/10A61P9/10A61P9/12A61P25/00A61P25/20A61P25/28A61P27/02A61K2300/00
Inventor 李昀泽陈红李建军常诚姚阳婧陈安琪顾锡镇裔楠常荧荥曹欣然
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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