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Traditional Chinese medicine composition for treating acute exacerbation of chronic obstructive pulmonary disease and preparation method thereof

A technology for chronic obstructive pulmonary disease and acute exacerbation, which is applied in the field of traditional Chinese medicine composition and preparation for the treatment of acute exacerbation of chronic obstructive pulmonary disease, and the field of medicine and preparation for treating lung diseases. , reduced quality of life, lack of treatment methods and other problems, to achieve the effect of improving fever, high content of active ingredients, and improving extraction efficiency

Pending Publication Date: 2020-10-09
CHINA JAPAN FRIENDSHIP HOSPITAL +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the acute exacerbation stage of chronic obstructive pulmonary disease, patients may manifest as fever, cough, expectoration, excessive phlegm, yellowish color, abdominal distension, and constipation. Clinical symptoms, prevention of re-acute exacerbation, lack of treatment for the cause
[0004] Traditional Chinese medicine has obvious characteristics or advantages in the treatment of acute exacerbation of chronic obstructive pulmonary disease, but there is currently a lack of new Chinese medicines for the treatment of acute exacerbation of chronic obstructive pulmonary disease, so as to solve the problem of recurrent acute exacerbation of COPD and promote disease progression and lung function and survival. The status quo of continuous reduction in quality

Method used

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  • Traditional Chinese medicine composition for treating acute exacerbation of chronic obstructive pulmonary disease and preparation method thereof
  • Traditional Chinese medicine composition for treating acute exacerbation of chronic obstructive pulmonary disease and preparation method thereof
  • Traditional Chinese medicine composition for treating acute exacerbation of chronic obstructive pulmonary disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Bitter almond 8g, gypsum 18g, melon 11g, rhubarb 8g, baicalin 11g, perilla seed 11g, roasted licorice 8g, golden buckwheat 14g, aster 11g

[0028] Preparation process: weigh each component according to the weight ratio, and crush all the components; take the pulverized perilla seeds and asters and extract them by steam distillation for 1 hour to obtain the total volatile oil, according to the weight ratio of 1:10, use Hydroxypropyl-β-cyclodextrin inclusion to obtain volatile oil inclusion solution; take the crushed bitter almonds, Trichosanthes, rhubarb, scutellaria baicalensis, roasted licorice, golden buckwheat and the medicinal residues of perilla seeds and asters, add 10 Double the amount of water for reflux extraction twice, each time for 1 hour, and combine the extracts to obtain extract 1; take the pulverized gypsum, add 6 times the amount of water for reflux extraction once, for 1 hour, to obtain the gypsum extract, and then combine with the extraction The liqui...

Embodiment 2

[0030] 6g bitter almond, 40g gypsum, 5g melon, 10g rhubarb, 6g baicalin, 6g perilla seed, 10g roasted licorice, 20g golden buckwheat, 8g aster

[0031] Preparation process: weigh each component according to the weight ratio, and crush all the components; take the pulverized perilla seeds and asters and extract them by steam distillation for 1.5 hours to obtain the total volatile oil. According to the weight ratio of 1:10, use Hydroxypropyl-β-cyclodextrin inclusion to obtain volatile oil inclusion solution; take crushed bitter almonds, Trichosanthes, rhubarb, scutellaria baicalensis, roasted licorice, golden buckwheat, perilla seed and aster dregs, and add 8 Double the amount of water for reflux extraction twice, each time for 1 hour, and combine the extracts to obtain extract 1; take the pulverized gypsum, add 8 times the amount of water for reflux extraction once, for 1 hour, to obtain the gypsum extract, and then combine with the extraction Liquid 1 was combined to obtain a ...

Embodiment 3

[0033] Bitter almond 10g, gypsum 25g, Trichosanthes 10g, rhubarb 12g, baicalin 12g, perilla seed 8g, roasted licorice 5g, golden buckwheat 9g, aster 5g

[0034] Preparation process: weigh each component according to the weight ratio, and crush all the components; take the pulverized perilla seeds and asters and extract them by steam distillation for 1.5 hours to obtain the total volatile oil. According to the weight ratio of 1:10, use Hydroxypropyl-β-cyclodextrin inclusion to obtain volatile oil inclusion solution; take crushed bitter almonds, trichosanthes, rhubarb, scutellaria baicalensis, roasted licorice, golden buckwheat and the dregs of perilla seeds and asters, add 12 Double the amount of water for reflux extraction twice, each time for 1 hour, and combine the extracts to obtain extract 1; take the pulverized gypsum, add 6 times the amount of water for reflux extraction once, for 1 hour, to obtain the gypsum extract, and then combine with the extraction Liquid 1 was com...

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Abstract

The invention relates to a traditional Chinese medicine composition for treating acute exacerbation of chronic obstructive pulmonary disease and a preparation method thereof. The problem of medicationfor treatment of chronic obstructive pulmonary disease in the acute exacerbation stage can be effectively solved; the composition comprises the following raw materials: semen armeniacae amarae, gypsum, trichosanthes kirilowii maxim, rheum officinale, scutellaria baicalensis, fructus perillae, radix glycyrrhizae preparata, wild buckwheat and radix asteris. In the adopted preparation method, according to the characteristics of the effective componetns of the traditional Chinese medicine composition, gypsum is independently extracted; the formation of flavonoid and anthraquinone component complexes is reduced, the extraction efficiency of effective components is improved, single extraction of volatile oil, inclusion of hydroxypropyl-beta-cyclodextrin so as to retain volatile components, thepreparation process is reasonable and feasible, the content of effective components are high, blending is convenient, and granules, tablets, capsules, oral liquids and pills can be prepared. The traditional Chinese medicine composition disclosed by the invention can obviously improve the symptoms of fever, cough, expectoration, excessive phlegm, abdominal distension and constipation caused by acute exacerbation of chronic obstructive pulmonary diseases.

Description

technical field [0001] The invention relates to a medicine for treating lung diseases and a preparation method, in particular to a traditional Chinese medicine composition for treating acute exacerbation of chronic obstructive pulmonary disease and a preparation method, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Chronic Obstructive Pulmonary Disease (COPD, Chronic Obstructive Pulmonary Disease) is a respiratory disease characterized by airflow limitation, which can lead to a progressive decline in lung function, seriously affecting the patient's daily work and quality of life, and later accompanied by cardiac insufficiency and systemic reactions. The course of COPD can be clinically seen as a stable period and an acute exacerbation period. The acute exacerbation period of chronic obstructive pulmonary disease refers to the process of a sudden acute exacerbation of the disease in patients who were originally in a stable per...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61K47/69A61P11/00A61P29/00A61P11/14A61P11/10A61P1/14A61P1/10A61K33/06
CPCA61K36/736A61K33/06A61K36/428A61K36/708A61K36/539A61K36/535A61K36/484A61K36/70A61K36/28A61K47/6951A61P11/00A61P29/00A61P11/14A61P11/10A61P1/14A61P1/10A61K2300/00
Inventor 张洪春晁恩祥敬岳
Owner CHINA JAPAN FRIENDSHIP HOSPITAL
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